ALIMEMAZIN (Alimemazinum). 10-(3-Dimetilamino-2- metilpropil) - fenotiazina gidrotartrat.

     Synonyms : Teralen, Alimezine, Isobutrazine, Methylpromazine, Nedeltran, Panectyl, Repeltin, Temaril, Theralen, Trimeprazine, Vallergan and others.

     Available in a gidrotartrata.

     The white or slightly yellow crystalline powder; Is soluble in water and alcohol.

     On chemical structure similar to diprazinu (see) and levomepromazinu. From diprazina distinguished by the additional methylene group (CH 2) in the side chain, and the lack of levomepromazina-DOS 3 team in position 2 fenotiazinovogo nucleus.

     Pharmacologically took intersection diprazinom, a protivogistaminnym drug with sedative activity and neyroleptikom aminazinom. More active on protivogistaminnomu and sedative action than Promethazine, and has characteristic of aminazina and other fenotiazinovyh Neuroleptics. Compared with aminazinom expressed adrenoblokiruyuschee has less effect; A weak antiholinergicheskoy activity.

     Alimemazin antipsychotic is a means to moderate activity. When expressed relatively little psychosis; Operates mainly as a mild sedative and protivotrevozhnoe means having a positive effect in senestopatii, impinge and phobias. Used primarily in psychosomatic manifestations, developing motivated vascular trauma, somatogennyh, infectious violations of central nervous system and neuro disorder. Sedate effect contributes to the normalization of sleep in patients in this category.

     In connection with protivogisteminnoy activity alimemazin also used in allergic diseases, especially respiratory tract, and skin irritation. Reassuring cough and has protivorvotnoy activity.

     In a relatively reasonable used in the child and gerontology practice, as well as in somatic medicine.

     Applied inside and intramuscularly. Inside designate an adult as a calming, protivoallergicheskogo, protivozudnogo of 10-40 mg / day; Children under 7 5-25 mg per day for 3 to 4 admission. In severe cases, and in psychiatry designate up to 100-400 mg / day (adults).

     Higher adult dose of 500 mg a day for those age-200 mg per day.

     Intramuscularly impose a 0.5% solution.

     The drug is usually well. There may be extrapiramidale violations (tremor, and less pronounced parkinsonizm akatiziya), the oppression of the central nervous system, hypothermia, in rare cases, agranulotsitoz.

     Contraindicated in severe liver and kidney diseases.

     Method of issuance : 5 mg tablets; 0.5% solution in ampoules to 5 ml (25 mg vials in); Drops 4% solution (1 drop of 1 mg preparation).

     Storage : in the dark spot.

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