ALENDRONAT SODIUM (Alendronat sodium).
Sodium salt (4-amino oksibutiliden) - difosfonovoy acid.
Synonym : Fosamaks, Fosamax.
The white crystalline powder. Mg in water, soluble in alcohol weak.
It has the ability to link contained in the bones gidroksiapatit inhibition activity of osteoclasts, resorption of bone.
With the organism drug accumulates in large numbers in the bone.
When ingestion absorbed about 25% of dose, bioavailability is only 0,6-0,8% T? up to 10 hours
Applied for the treatment of osteoporosis, especially for women in menopause, as well as disease Pedzheta (distortive osteit).
Is the inside of 0.01 g (10 mg) 1 every day for half an hour before eating (or earlier). Œhigh regular glass, not mineral water. Extras appointed interior drugs calcium per 0.5 grams of calcium per day. Treatment for a long-term (years). After three years Wards dose of sodium (fosamaksa) reduced to 0,005 grams (5 mg) per day.
When illness Pedzheta appointed to 0.04 g / day for 6 months.
In the process of treating an increase bone mineral density and reduce the incidence of new fractures.
In applying the drug may disorder of the digestive tract (constipation or diarrhea, flatulence, pains in the stomach, esophagitis), allergic reactions (skin rash, erythema), headache.
Contraindications to gipokaltsiemii, severe kidney failure.
Products containing calcium and its products should be no less than 1-2 h after administration of Wards, as well as delaying the suction Wards (and other bifosfonatov) of the bowel.
Product : pills to 0.01 g (10 mg) (N 28).
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