ALDESLEYKIN (Aldesleukin).

     Recombinant (human) analogue interleykina-2 (obtained using chain genes inteoleykina-2 intestinal bacillus). Limfokin.

     Protein containing 133 amino acid balance. 125-L- serin-2-133- interleykin-2. C690H1115N177O203S6 (15600 Dalton).

     Synonym : Proleykin, Proleukin.

     Has ummunomodulating and antitumor effects. As immunomodulator activate endogenous protection body, promotes T-lymphocyte, limfokinaktivirovannyh killernyh cells and lymphocytes in opuholinfiltruyuschih killernye cells have anticancer properties. Has interferonogennoe and-effect promotes education? - Interferon, and Tumor Necrosis Factor.

     Applied mostly with kidney cancer (with metastasis), and melanoma.

     Assign intravenous drip at the rate of 1 mg / m 2 per day; Enter a continuous Infusion for 5 days; Then after the 2-6 day break repeat Infusion within 5 days (one induction cycle). After three weeks repeat cycle. Depending on the performance and endurance to hold up to 4 cycles.

     Solution to prepare ex tempore. In a bottle with a drug impose 1.2 ml of water for injection and carefully pokachivayut it (not vstryahivaya) to complete dissolution. For infusions received solution to throw in 5% glucose solution (500 ml). By glucose solution can be added 0,1% human albumin solution.

     The application offers different drug side effects : arterial hypotension, arrhythmia, increased strokes, blood clotting violations, thrombosis, oliguriya, headache, diarrhoeal phenomenon, violations of the lungs, liver and kidneys, mialgiya, arthralgia, apnoea response, speech disorders, memory and view, thrombocytopenia, radiation, anemia and other treatment to be carried out under close medical supervision.

     Contraindications : far coming stage cancer, multiple metastases, severe cardiovascular disease predisposition to convulsant reaction, radiation, thrombocytopenia, the effects on respiratory, infectious and autoimmune diseases, pregnancy, breast-feeding.

     Product : dried powder for injection solutions in bottles of 1.2 mg (18 million IU / kg).

     Storage : List A.

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