ETATSIZIN (Aethacizinum). 3-Karbetoksiamino-10- (West dietilaminopropionil) - fenotiazina hydrochloride.

     The white crystalline powder. Slowly soluble in water, soluble in alcohol.

     On chemical structure similar to etmozinu. Provides antiaritmicheskoe effect. Refers to Group I antiaritmicheskim drugs. Lengthens the time of initiation and duration of periods refrakternyh predserdy, predserdno- ventricular node predserdno- premature Beam (Beam Gisa), and Purkinje fibers.

     Apply in zheludochkovyh and nadzheludochkovyh ekstrasistoliyah, and the couple ksizmalnyh neparoksizmalnyh zheludochkovyh and nadzheludochkovyh tahikar stages, epileptic mertsatelnoy tahiaritmii, including in the syndrome of premature ventricular stimulation. Assign also infarction heart attack, patients violations heart rhythms.

     Assign inside (regardless of when meals) and intravenously.

     Intravenous to impose kupirovaniya attacks tachycardia, as well as "threatening" ventricular arrhythmia, which requires its immediate suppression.

     Inside appoint etatsizin from 50 mg three times a day. In caratra statochnom effect of increasing doses (elektrokardiograficheskim under control) to 50 mg four times a day (200 mg per day) or 100 mg three times daily (300 mg / day). Once the effect of a supportive therapy in INDICATORS ers selected minimum dose.

     The effect of the drug inside the reception is usually 1 - 2 day.

     The length of treatment depends on the form of arrhythmia, the effectiveness of drug therapy and portability.

     Give intravenous dose of 0.25 to 1 mg / kg. The contents of one ampoule (2 mL of 2, 5% solution = 50 mg) razvodyat 20 ml isotonic sodium chloride solution and enter slowly (at the rate of 10 mg drug per minute) under the supervision of AD and EKG. The total dose of 1 mg / kg. Introduction soderzhi can one ampoule drug (50 mg) should last at least five minutes. Because hand, more effective with fewer adverse events (inotropny negative effects) is a drip (50-150 mg in 100 ml and 200 isotonic sodium chloride solution).

     Etatsizin usually more efficient than etmozin, but more is poboch by the phenomenon. When admission into possible nausea, dizziness, drug along accommodation; With the introduction of intravenous-noise in the ears, "suffering" various parts of the body, "pool" before the eyes. These phenomena are after introduction.

     In applying etatsizina should take into account its effect on the inhibition conductive system hearts (and atrioventrikulyarnuyu vnutrizheludochkovuyu conductivity) and sokratimost osteoporosis. The product can provide aritmogen substantive effect. Perhaps reducing coronary blood flow. In the treatment process requires careful monitoring of the cardiovascular system and the general condition of the patient.

     Contraindications: violations conductivity heart sinoatrialnaya Cadastre II has been much atrioventrikulyarnaya blockade II-III degree blockade vnutrizheludochkovoy conducting system, as well as severe cardiac lack accuracy, hypotension, a violation of the liver and kidneys. Caution is needed if symptoms of weakness sinusnogo node, I atrioventrikulyarnoy blockade extent incomplete blockade feet beam Gisa and Purkinje fibers.

     Method of production: tablets, thickly coated in 0.05 g (50 mg); 2, 5% solution in ampoule of 2 ml (50 mg).

     Storage: List B. pills in a dry, sheltered from the world scene; Ampoule in sheltered from the world scene with a temperature of not more than 10 'C.

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