Lekarstva (Acrichinum). Metoksi-6- hlor-9- 2 - (1-methyl dietilaminobutilamino) - acridine digidrohlorid.
Synonyms : Atabrine, Atebrin, Chemiochin, Chinacrine, Haffkinine, Hepacrin, Italcihne, Malaricida, Mecaprine, Mepacrine hydrochloride, Mepacrini hydrochloridum, Mepacrinum, Methochin, Methoquine, Palacrin, Palusan, Pentilen, Quinacrine, Tenicridine.
Yellow melkokristallichesky powder, bitter-tasting. Mg in water (20 + with the 'X 3%; Solubility increases with heating solution). Divorced flyuorestsiruyut aqueous solutions. Aqueous solutions for injection are filled.
Akrikhin rapidly absorbed from the gastrointestinal tract; After receiving therapeutic doses of maximum concentration in the blood was after 2 to 3 hours; High levels of the drug in the blood is retained for several hours. Akrikhin long delays in the body. Write mainly kidneys, partly out bile, in the colon can dvenadtstiperstnoy second skin. Part of drugs destroyed in the body.
The nature of antimalarial Akrikhin close to hingaminu (chloroquine). Because that Akrikhin less active and, in addition, cause staining skin and mucous membranes, it is now little used, as an antimalarial drug.
Akrikhin protivoglistnoe used as a tool for treating lupus red, cutaneous leishmaniasis, psoriasis.
As antimalarial drug taking Akrikhin inside after eating, squeezed abundant water. At the rate designate 1, 5 grams : 1 day to 0.3 g 2 times every 6 h, 2, 3, 4-day - at 0.3 grams-1 admission. In 1-day treatment can be given 0.3 g, in this case, the course of treatment is extended for one day. In severe infections during treatment may continue for up to seven days.
The numbers akrihina daily doses for children are the same as for bigumalya.
As protivoglistnoe vehicle Akrikhin apply to tsestodozah : invasions bull tsepnem (teniidoz), dwarf tsepnem (gimenolepidoz), a lentetsom (difillobotrioz). Eve and day care are shabby food restriction of fat, salt and bitter products. At night appoint a saline laxative. Morning raise sewage enema and shock are all appointed akrihina dose (take 1 - 2 tablets every 5 to 10 minutes, adding water œhigh gidrokarbonata sodium).
Assign Lekarstva in the following doses : adults - 0.8 g; Children 3 4 years - 0.15 - 0.2 g, 5-to 6 - 0.25 - 0.3 g, 7-9 - 0.35 - 0.4 g, 10 - 12 years - 0.45 - 0.5 g; 13-14 - 0.6 g, 15 - 16 years - 0.7 g.
A 1 / 2 - 1 hour after receiving the latest offer saline laxative pills or infusion hay complex. Breakfast allow 1 to 2 h after administration slabitelnogo. If within 3 h after administration slabitelnogo no chairs, put enema (adults from 5 cups warm water, fewer children respectively). If parasites emerged without the ball, putting an additional 1 to 2 enema.
In teniidoze difillobotrioze and treatment to one; When gimenolepidoze 4-cycle 3 day intervals seven days. Diluted designate an adult to 0.3 g (2 receive 20 minutes) a day shock; In one-day first round after 2 h saline laxative offer.
When in the process of deworming nausea and vomiting recommended bed rest, Piešťany to nadlozhechnuyu area swallowing pieces of ice.
Recently Akrikhin protivoglistnoe used as a tool in combination with fenasalom (see), while akrihina dose can be reduced.
When treating Giardiasis (see also Aminohinol, Furazolidon), Lekarstva take three times a day for 30 minutes before eating during the eight days in the following doses (at the reception) : Children under 2 years - 0,012 - 0,015 g, 3 year-0.02 - 0.025 g, 4 years - 0.03 - 0.04 g, 5-to 7-0.05 - 0.075 g, 8-14 years - 0.1 g, 14 - 16 years and over-0.1 - 0.15-Assign city also cycles; first round of 5 days, the second three-day third 3-day interval between them for seven days.
Higher doses akrihina for adults; Single 0.3 g; Daily 0.6 g.
In early forms of cutaneous leishmaniasis have injections akrihina 5% solution (1% solution novocaine) in the pimple, repeat injections after 3 to 4 weeks.
When red erythematosus (see also Hingamin, Aminohinol) shall appoint 0.1 g akrihina three times a day course for 10 days with rates between 5 to 7 days; A 4 - 5 courses. Sometimes, moreover, obkalyvayut pockets defeat 2 - 5% solution akrihina.
Akrikhin usually well. Observed admission akrihina yellow staining skin is harmless, but could be within a few weeks and after treatment. In overdose, and in rare cases after receiving normal doses akrihina could experience adverse reactions : <akrihinovoe intoxication> motor and speech excitation loss guide, the continued normally a few hours; <Akrihinovy psychosis> accompanied by hallucinations, depression and initiation or other phenomena continuing usually not more than a week.
When neurological symptoms Akrikhin cancel, give plenty of fluids, glucose and reassuring designate funds.
Akrikhin contraindicated for people with mental illness, and patients who have previously been observed in the employment drug violations nervous activity. The relative contraindications : fragile psyche, a sharp violation of renal excretory function, holemiya, dramatic coloration of skin at the time of application akrihina delay for the drug with urine.
Do not assign Akrikhin while primahinom and hinotsidom or shortly before use these drugs (see Primahin).
Method of issuance : powder; Tablets of 0.1 g and tablets, coated to 0.05 g.
Storage : List B. The well ukuporennoy packaging keeps out of the light; Pill-in the dark spot.
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