ATSITRETIN (Acitretin).

     9 - (4-Metoksi-2, 3,6 - trimetilfenil) -3,7 - dimethyl-2, 4,6,8 - nonatetraenovaya acid.

     Synonym : Neotigazon, Neotigason.

     On chemical structure atsitretin (neotigazon) differs from tigazona that is relevant tigazonu acid, and its tigazon - ethyl ester (somewhere in the side chain instead SOON radical group SOOS2 N5).

     According to the atsitretin close to tigazonu but moved slightly better, although some degree have side effects, as well as teratogennoy activity.

     Quickly and completely absorbed in the digestive tract, bioavailability of 60%, C max -1-4 h, T? 50-h; biotransformation are in the liver (in some cases formed etretinat), presented with urine and bile over from one month to two years.

     When applied in the form of heavy psoriasis, congenital ihtioze, depriving (red, volosistom, flat, otrubevidnom) disease Dare.

     The operation is linked to the normalization of renewal, differentiation and orogoveniya skin cells.

     Assign inside (while eating) : adults on 0,025-0,03 g (25-30 mg) one time a day, within 2-4 weeks may increase daily intake to 0,075 g (75 mg); Children - at 0.5 mg / kg / day (if necessary by 1 mg / kg per day, but not more than 35 mg per day).

     In applying the drug phenomenon likely gipervitaminoza A (dry skin and mucous membranes, skin peeling, fractures nails, hair loss, hyperlipidaemia, giperkaltsiemiya etc.).

     Contraindicated in pregnancy (risk teratogennogo action), when expressed violations of liver and kidney failure, severe cardiovascular disease.

     Do not use medication with retinol (vitamin A), tetratsiklinovymi antibiotics, methotrexate and other drugs that violate liver and kidney function.

     Product : Capsule to 0.01 and 0.025 g (10 and 25 mg) (N 50, 100).

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