Oksolinievaya acid (acidum oxolinicum)

OKSOLINIEVAYA ACID (Acidum oxolinicum). 5, 8-Digidro-8- okso-5- ethyl-1, 3-dioksolo (4 5-d) hinolin-7- carboxylic acid.
     Synonyms : Gramurin, Dioxol, Emyrenil, Gramurin, Nefroclar, Nevopax, Nidantin, Oxabid, Oxobid, Oxol, Oxolinic acid, Pietil, Prodoxol, Urbid, Uribid, Urigram, Uristatic, Uritrate, Uropax And p.
     Domestic drug dioksatsin (Dioxacinum).
     White with the amber or kremovatym (up yellow) melkokristallichesky white powder. Almost nerastvorim in water and alcohol.
     For antimicrobial spectrum of acid oksolinievaya not significantly different from nalidixic. Preparation is most effective against gram bacteria (Proteus, Escherichia coli, Staphylococcus aureus). Effective with the resistance of microorganisms to other chemotherapy drugs, with the exception of Moldova, as in the application of this group of drugs is a cross-resistance.
     In in vitro experiments acid oksolinievaya 2 to 4 times more active than nalidiksovaya. However, acid oksolinievaya more neyrotoksichna.
     Applied acid oksalinievuyu mainly urinary tract infection ways : anesthetic, pielitah, medicine, prostate, and to prevent infection with tsistoskopii, catheterization urinary tract.
     Assign inside adults and children over 12 years of age to 2 tablets (0.5 g) three times a day, for children from 2 to 12 years - 1 tablet (0.25 g) three times a day. Is immediately after eating. The course of treatment of at least 7 to 10 days (up to 2 to 4 weeks).
     In applying acid oksolinievoy possible nausea, vomiting, diarrhea, flatulence, headache, anxiety, tachycardia : sleeping, weakness. These phenomena are usually alone. However, the individual receiving the drug stop intolerances.
     In connection with exciting action on the central nervous system should be careful in appointing a drug patients epilepsy and other central nervous system diseases.
     Caution is needed in the appointment of a drug to patients with deficiency of the liver and kidneys (lower doses!) , The elderly.
     Contraindicated in pregnancy and breastfeeding, and children up to 2 years.
     Product : pills to 0.25 grams in a package of 50 pieces.
     Storage : List B. In the dark spot.

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