GLUTAMINOVAYA ACID (Acidum glutaminicum). 2-Aminoglutarovaya acid.

     Glutamic acid is replaceable by amino acids. She comes into contact with food, but also synthesized in the body when pereaminirovanii proteins in the process of dissolution. For use as a medicine is a synthetic get through.

     Synonyms : A cidogen, As idulin, idum As glutamicum, Glutan, Glutansin and others.

     The white crystalline powder acidic taste. Little is soluble in cold water; Soluble in hot water; Almost nerastvorim of alcohol. Aqueous solutions (pH 3, 4, 3, 6) are sterilized at a temperature of 100 + 'C for 30 min.

     Glutamic acid plays an important role in the life of the body : participating in the exchange, Carbohydrate and protein stimulates oxidation processes to remove and drain the body of ammonia, increases the body's resistance to hypoxia. It also facilitates synthesis of acetylcholine and adenozintrifosfornoy acid, potassium ion transport. As part of protein, miofibrill plays an important role in the body skeletal muscles.

     Recently, attached special importance to the central role neyromediatornoy glutamic acid. It belongs to neyromediatornym amino acids, enabling the transfer of excitation in the central nervous system synapses.

     Endogenous Glutamic acid found in large quantities of proteins in gray and white matter brain. If ingestion is well absorbed, crosses the blood-brain barrier and cellular membranes. Introduced in the organism, it is recycled in the process of metabolism; About 4 - 7% return kidney unchanged.

     In clinical practice Glutamic acid is used primarily for the treatment of central nervous system diseases : epilepsy (fits with mostly small equivalents), psychoses (somatogennyh, intoksikatsionnyh, involyutsionnyh), reactive state, ran with the phenomenon of depletion, hunters, etc. The drug is used in pediatrics delayed mental development of various etiology, cerebral paralysis, Down's syndrome, an acute polio and recovery period. There were also positive results obtained in the application of acid (with or pahikarpinom glikokolom) in patients with progressive myo. It is also recommended to appoint glutaminovuyu acid for the prevention and removal of the neurotoxic effects that may arise in the application of isoniazid and other drugs group hydrazide, izonikotinovoy acid.

     Assign into adults usually 1 g 2 - 3 times a day. Children under 1 year are at 0.1 grams to 2 years - 0.15 g, 3 to 4 years 0,25 g, 5-to 6 - 0.4 g, 7 to 9 years 0,5-1 , 0 g, 10 years or older on 1 g (2 - 3 times a day). When the mental retardation appoint 0.1 - 0.2 g / kg in a few months.

     Is 15 to 30 minutes before eating, and the development of diarrhoeal phenomena, during or after a meal. The course of treatment for 1 - 2-6-12 months.

     Young children can appoint glutaminovuyu acid in the form of suspensions, prepared from granules. This content to throw a bottle svezheprokipyachennoy warm water, Plucker labels to its 100 ml. In 1 ml received (with shaking) slurries containing 0.01 g of glutamic acid. Accordingly dose for children under 1 year of 10 ml per reception (30 ml / day); From 1 to 2 years, respectively, 15 and 45 ml; 3 - 5-25 years and 75 ml.

     Glutamic acid is usually well tolerated. Possible side effects (vomiting, liquid stool, stir), after reducing the dose received. With long-term use may decrease in hemoglobin and radiation.

     Glutamic acid is not suitable frenzied conditions, diseases of liver, kidney, gastrointestinal tract and blood-forming organs, elevated anxiety, violently disruptive Psychotic reactions.

     During treatment to be systematically studied urine and blood.

     If glutamic acid interference in the form of powder to rinse his mouth after taking a weak solution of sodium gidrokarbonata. Preferably use for admission into tablets, coated skin (Ta bulettae As idi glutaminici obductae), or tablets, dissolved in the gut (Ta bulettae As idi glutaminici enterosolubiles).

     Method of issuance : powder; The tablets, coated in 0.25 g; Pills, soluble in the gut, for 0.25 and 0.5 g; Granules of 10 in orange glass bottles labeled 10 ml (attached to a bottle filled with division of 2, 5 and 20 ml).

     Storage : pills, in the dark places; Granules-dry, the dark places; Prepared suspension stored in the refrigerator no more than 10 days at room temperature no more than 7 days. Suspension vzbaltyvayut before consumption.

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