Etakrinovaya acid (acidum etacrynicum)
ETAKRINOVAYA ACID (Acidum etacrynicum). 2 Dihlor-4- 3-(2-metilen-1- oksobutil) - fenoksiuksusnaya acid, or 4 - (2 - ethyl akriloil) -2, 3-dichlorophenoxyacetic acid.
C inonimy: Uregit, Crinuril, Ecrinex, Edecril, Edecrin, Endecril, Etacrynic acid, Hydromedin, Otacril, Uregit.
Is diureticheskim powerful tool. On mechanism of close to furosemide, but no increases for bikarbonata and did not violate the electroplating of blood.
A fast; Diurez begins in 30 -60 minutes, reaching a maximum at 2 h after a single admission continues -9 6 h.
Assign with infections in patients with circulatory insufficiency; In severe renal origin, particularly resistant to the other diuretics; Severe swelling in the lungs; Brain swelling.
Provides moderate antigipertenzivnoe effect; In hypertensive disease can be combined with gipotenzivnymi means.
Assign inwards from 0.05 g (50 mg), increasing the need for a daily dose of the drug to 0,1 - 0,2 city usually take all morning dose of the drug (after eating).
Diuretichesky effect is often more pronounced if the drugs are not daily, and with a break 1 - 2 days.
Intravenous (0.05 g) introducing whenever rapid effect (see Furosemid).
In a lengthy drug application might fiber and gipohloremichesky alkaloz. The simultaneous use of diuretics kaliysberegayuschih increases diureticheskoe of drugs and reduces gipokaliemiyu and alkaloz.
Etakrinovaya acid postponed worse than furosemide, especially patients with renal insufficiency.
Using the drug could dizziness, weakness, dispersion, diarrhoea.
Treatment should be held against the backdrop of diets rich in potassium, and if necessary appoint drugs potassium.
Contraindications are the same as for dihlotiazida. The product is not recommended anurii and pregnant. Children at an early age appointed only in exceptional circumstances (with resistance to other diuretikam). In liver cirrhosis of the drug requires careful medical supervision.
Method of production: tablets of 0.05 g in the package of 20 pieces; In ampoule containing 0.05 grams of sodium salt etakrinovoy acid, which dissolve isotonic solution of sodium chloride or glucose.
Storage: List B.
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