ADENOZINTRIFOSFORNAYA ACID (Acidum adenosintriphosphoricum).

     Adenozin-5'- trifosfornaya acid, or trifosforny broadcast 9-b -D- ribofuranozida.

     Synonyms adenozintrifosfornoy acid and its sodium salt : ATF, Atrifos, Miotrifos, Fosfobion, Adephos, A trifos, A triphos, rtrifos So, Fosfobion, Muo triphos, Striadyne, T riadenyl, Trifosfodin, Trifosyl, Triphosaden, T riphosadenine etc.

     ATP, or adenosine (ATF) is a natural part of the fabric of the human body and animals. It is formed by the oxidation reaction and the process of fission glikoliticheskogo carbohydrates. It is particularly rich in smooth muscles of poperechnopolosatoy muscle. Its content in skeletal muscle reaches 0.3%.

     ATF has been involved in many metabolic processes. In conjunction with aktomiozinom it falls into adenozindifosfornuyu acid (ADF) and inorganic phosphate, the energy is released, much of which is used for mechanical muscles, as well as synthetic processes (fusion protein, urea and intermediate products of metabolism). In dystrophic process in muscles, a decline of content in muscle or violation of its resinteza. ATF considered one of the mediators in the initiation adenozinovyh (purinergicheskih) receptors (O mediator, and other properties of adenosine see Theophylline, heart diseases, Caffeine.) . In addition, he is involved in the transfer of neural excitation in the adrenergic and holinergicheskih synapses, facilitates vozbuzhieniya in vegetative locations and the transfer of proceedings from wandering nerve on the heart. I think also that the ATF is inhibitor mediator in the gastrointestinal tract released postganglionarnymi fibers emerging from auerbahovskogo (intermuscular nervous) weave, as well as exciting as mediator in the tissues of the bladder.

     Experimental data show that the ATF increased coronary and cerebral circulation.

     For medical use of ATF from the muscle tissue of animals.

     ATF-hygroscopic white crystalline powder. For medical applications available solution adenozintrifosfata 1% sodium for injection (Solutio Natrii adenosintriphosphatis 1% p ro injectionibus).

     A solution of sodium adenozintrifosfata is a colorless or slightly yellow liquid; PH 7 0 -7 3.

     Earlier on ATF widely used in chronic coronary insufficiency. It, however, that it across cell membranes requires a lot of energy, which questioned the role of ATF as a source of energy for uterine ability to attack and improve its metabolic processes.

     The main application of sodium triphosphate is currently in the treatment of muscular dystrophy and atrophy, peripheral vascular spasm (peremezhayuscheysya limp, the disease Reynaud, obliteriruyuschem trombangiite). Sometimes used to promote labor activity.

     In recent years found that the ATF can be successfully used for epileptic nadzheludochkovyh tahikardy edema. Believed to be formed due to the breakdown of adenosine ATF, the overwhelming automaticity sinusno- predserdnogo hub and heart conducting miotsitov (Purkinje fibers). Part of the effect is related to the blockade membrane calcium channels, increased permeability of the membrane attack for potassium ions.

     For the treatment of muscular distrofy violations and other peripheral circulatory diseases ATF usually intramuscularly. In the first 2 to 3 days to enter 1 time per day to 1 ml of 1% solution, and in the following days two times a day, or 2 ml of 1% solution of 1 per day. The course of treatment consists of 30-40 injection.

     Again course depending on effect through 1 - 2 months.

     For edema nadzheludochkovyh tachiarrhythmia injected dose of 10 to 20 mg (1 - 2 ml of 1% solution). Enter quickly (within 5 to 10). The effect is about 20-40 seconds.

     If necessary, repeat the introduction of the drug after 2 to 3 minutes.

     When ATF intramuscular a possible headache, tachycardia, increased diureza with intravenously, nausea, headache, Blush person. These phenomena are alone.

     There should be appointed with fresh ATF heart attack.

     Product : 1% solution in 1 ml ampoules.

     Storage : in the dark place at a temperature of up to + 3 + 5 'Ñ.

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