ATSETILSALITSILOVAYA ACID (Acidum acetylsalicylicum).

2-Atsetoksibenzoynaya acid :

     SINONIMY : Anopirin, Apo- Asa, Aspivatrin, Aspilayt, Aspinat, Aspirin, Aspirin- Direct, Aspirin- cardiovascular, Aspirin UPSA, Aspitrin, ASS- Ratiofarm, Atsenterin, Atsetilsalitsilbene, Atsilpirin, ATSTS, Bartel Drugs A. S. K., Bufferan, Bufferin, Kolfarit, Mikristin, Our Choice-analgetik, Novandol, Novasan, Novasen, New Ludwig, NYU- Oakland 75 Cardio aspirin Plidol, Ronal, Salorin, Sprit- Lyme, Trombo ACC Uolsh- asalgin, Upsarin UPSA , Inc. E Payne, Elkapin, Acenterin, Acesal, Acetosal, Acetylin, Acetylsalicylbene, Acetylsalicylic Acid, Acetysal, Acylpyrin, Anopyrin, Apo-Asa, Aspilite, Aspirin, Aspisol, Aspivatrin, Asposal, Aspro, Astrin, Ataspin, Bartell drugs A. S. A. Bayaspirin, Bebaspin, Benaspir, Bispirine, Bufferan, Bufferin, Caprin, Cetasal, Citopyrine, Clariprin, Colfarit, Darosal, Durasal, Easprin, Elkapin, Endosalil, Endospirin, Eutosal, Genasprine, Helicon, HL-Paim, Isopirin, Istopirin , Micristin, Monasalyl, New-asper, Novandol, Novasan, Novasen, Novosprin, NU-seals 75 cardio-aspirin, Our choice-analgetic, Panspiril, Plidol, Polopiryna, Prodol, Rhonal, Rodopytin, Ronal, Ruspirm, Salacetin, Saletin, Salorin, Sprit-Lime, Temperal, Trombo ASS, Vicapirine, Walsh-asalgin, Zorprin and others.

     White crystals or small ball of light crystalline powder. Few rastvorima water (rastvorima in hot water), easy-to alcohol, in solutions caustic alkali and hydrogen.

     Aspirin has anti-inflammatory, analgesic and blood effects, and it is widely used in the frenzied state, the head pain, migreni2, chamber and as protivorevmaticheskogo funds.

     AGAINST of acetylsalicylic acid (and other saditsilatov) explain its impact on the processes taking place in the middle of inflammation : reducing capillary permeability, low activity gialuronidazy, limiting the power of the inflammatory process by braking education ATF, etc. The mechanism of anti importance inhibiting biosynthesis prostaglandines.

     Anti effect due to the influence of thermal gipotalamicheskie points.

     Analgesic effect due to the impact of the centres of pain sensitivity and the ability to reduce salitsilatov algogennoe bradikinina effect.

     An important feature of acetylsalicylic acid, which has attached great importance is the ability to provide antiagregatsionnoe (inhibition of spontaneous and induced aggregation of platelets).

     Substances of antiagregatsionnym actions were disseminated widely in medicine to correct the violations and prevent gemoreologicheskih tromboticheskih complications in patients with heart attack, a violation of cerebral circulation and other cardiovascular diseases. Therefore, mention may be made of these substances in the group antiagregatsionnyh funds. These properties acetylsalicylic acid described in the section (see Antiagreganty).

     Aspirin stimulates down uric acid in violation of its reabsorption in the renal reabsorption.

     Once inside quickly and almost completely absorbed, T1 / 2 is not more than 15-20 minutes; Acetylsalicylic acid (and other musk) easily spread into many tissues (including virus and liquid skin); Being biotransformation in the bowel wall and the liver with the formation of salicylic acid and other active metabolites appears kidney mainly unchanged.

     Assign as tablets inside after eating.

     Normal adult dose of painkiller and cough (and frantic diseases, headache, migraines, disease, etc.) 0.25 to 1 g 3-4 times a day; For children, depending on age, ranging from 0.1 to 0 , 3 g per reception.

     In rheumatoid arthritis, infectious allergic myocarditis, rheumatoid polyarthritis designate long-term adult 2-3 grams (less than 4 grams) per day, children under 0.2 grams for each year of life per day. Under the dose for children age 1 year was 0.05 g, 2 years - 0.1 g, 3 years - 0.15 g, 4 years - 0.2 g. Starting with 5 years of age may be nominated tablets on 0,25 g per reception.

     Antiinflammatory effects usually in 1-2 days after receiving the drug, acute inflammation suppressed for a few days, with a chronic course of developing a long-term effect and is not always complete.

     Aspirin is widely used in outpatient facilities. We should bear in mind that using it should be treated with caution because of the possibility of side effects (profuznoe sweating, noise in the head and easing hearing angionevrotichesky swelling, skin and other allergic reactions).

     In a long (without medical supervision) receiving acetylsalicylic acid, sometimes side effects such as diarrhoeal disorders and stomach bleeding, mucosal lesion not only stomach, duodenum and colon, interstitial nephritis, azotemiya, acute renal failure, principally syndrome, as well as increased the symptoms of congestive heart failure.

     The emergence of stomach ulcers and stomach bleeding in the application of acetylsalicylic acid is not only its Eferent of (blood clotting factors braking, etc.), but direct irritant effect on the mucous membrane of the stomach, especially when drug use in producing tablets (this applies to the sodium musk ).

     To reduce ultserogennogo of gastric bleeding and atsetilsalitsilovuyu acid (sodium and musk) should be taken only after eating pills to carefully grind and zapivat more liquid (milk is better). There are, however, indications that gastric bleeding may occur in the employment acetylsalicylic acid after eating. To reduce irritants in the stomach is recommended after receiving acetylsalicylic acid to alkaline mineral water or sodium solution gidrokarbonata, accelerating salitsilatov allocation from the body.

     Abroad, acetylsalicylic acid tablets often produce a melkokristallicheskogo powder oschelachivayuschimi (buffer) additives and producing special kishechnorastvorimoy shell.

     With long-term use salitsilatov should consider the possibility of developing anemia, and thrombocytopenia radiation.

     Due to allergic reactions likely to be careful in appointing acetylsalicylic acid (and other salitsilatov) individuals with a heightened sensitivity to penitsillinam and other "allergogennym" LS.

      With heightened sensitivity to acetylsalicylic acid sometimes develops aspirinovaya asthma, for the prevention and treatment methods which desensibiliziruyuschey therapy using escalating doses aspirina1.

     Recent reports on the possible threat of acetylsalicylic acid to reduce body temperature with influenza, acute respiratory diseases and other fever among children in connection with the observed cases of the syndrome Ray (gepatogennaya encephalopathy).

     Ulcers stomach and duodenal ulcers and gastrointestinal bleeding are contraindications to the appointment of acetylsalicylic acid and sodium musk. Contraindicated the use of acetylsalicylic acid with ulcers in history, with gantries hypertension, venous stagnation (in conjunction with decreasing resistance gastric mucous membrane), while haemorrhagic diathesis, rasslaivayuscheysya anevrizme disorders, heart Insufficiency UNESCO, severe violations of the liver and kidney, thrombocytopenia, lack of vitamin C.

     According to available experimental data on the effect of acetylsalicylic acid teratogennom not to appoint her, as well as its preparations women I trimester of pregnancy.

      ñâÿçè ñ âëèÿíèåì íà àãðåãàöèþ òðîìáîöèòîâ, îïðåäåëåííîé àíòèêîàãóëèðóþùåé àêòèâíîñòüþ (à òàêæå ñ âåðîÿòíîñòüþ ðàçâèòèÿ àíåìèè) ïðè ëå÷åíèè àöåòèëñàëèöèëîâîé êèñëîòîé íåîáõîäèìî ïåðèîäè÷åñêè ïðîâîäèòü èññëåäîâàíèÿ êðîâè. When violations blood coagulability, especially with hemophilia, may bleeding.

     For early detection of ultserogennogo must periodically to explore cal blood.

     Bear in mind that under the influence of acetylsalicylic acid to the growing anti - (coumarin derivatives, unchanged), gipoglikemicheskih drugs (derivatives sulfonylureas), tromboliticheskih and other platelet aggregation inhibitors; Increased risk of stomach bleeding while applying glucocorticosteroids, increasing side effects methotrexate.

     Paracetamol, caffeine, protivogistaminnye drugs increase the risk of side effects acetylsalicylic acid.

     FORM OUTPUT : pills to 0.1 g (to risk) for children and 0.25 and 0.5 g for adults.

     storage : List B.

     Abroad also produces :

     Aspirin fitness (cardio Aspirin) - kishechnorastvorimye pill, containing 0.1 or 0.3 g of acetylsalicylic acid;

     Blood clot ASS (Thrombo ASS) - kishechnorastvorimye tablets, containing 0.05 g or 0.1 g of acetylsalicylic acid.

     There are a number of other imports and "heart" of acetylsalicylic acid (mostly pills to 0,325 g) : Aspilayt (Aspilyte), "Aspirin York" (Aspirin "York"), Aspirin "Quality" (Aspirin "Quality"), Aspirin- Milt (Aspirin-Miltom) Aspirin UPSA (Aspirin UPSA), Bufferan (Bufferan), Bufferin (Bufferin) Novandol (Novandol) NYU- Oakland 75 Cardio aspirin (NU-seals cardio-aspirine 75).

     These pills proglatyvayut not liquid, squeezed a small amount of water, 1 per day. On antiagregantnomu actions are no different from the usual acetylsalicylic acid, but their coating prevents irritating effect on the mucous membrane of the stomach and provides better portability.

     There are a number of finished dosage forms (tablets, powder tablets), containing atsetilsalitsilovuyu acid in combination with other LS (paracetamol, caffeine, phenobarbital).

     Widely used on domestic combinations, including : Tsitramon P (Citramonum P) tablets and Tsitrapar (Citraparam) - capsules containing acetylsalicylic acid 0.24 g, 0.18 g paracetamol and caffeine 0.03 g; Tsitrapak (Citrapacum) - tableki containing acetylsalicylic acid 0.24 g, 0.18 g paracetamol, caffeine 0.03 g, 0.05 g ascorbic acid and citric acid 0.005 g; Askofen- P (Ascophenum-P) - pill containing acetylsalicylic acid. paracetamol and 0.2 grams of caffeine and 0.04 g.

     Known abroad combined drugs, which is acetylsalicylic acid are :

     Alka--Seltzer tablets (bubbly), acetylsalicylic acid containing 0,324 g, 0,965 g citric acid and sodium gidrokarbonata 1,625 g;

     Alka- approx-pill (bubbly), acetylsalicylic acid containing 0.33 grams of sodium gidrokarbonata 1,685 g, 0,685 g citric acid and glycine 0.1 g;

     Aspirin plus "X" - pill (bubbly) containing acetylsalicylic acid, and 0.4 g of ascorbic acid 0.24 g;

     Aspirin UPSA with vitamin C tablets - (bubbly) containing 0.33 g of acetylsalicylic acid and ascorbic acid 0.2 g;

     Volume of vitamin C-granulyat bags containing acetylsalicylic acid, and 0.5 g of ascorbic acid 0.3 g (dissolving in a glass of water);

     Tomapirin-pill containing acetylsalicylic acid 0.25 g, 0.2 g paracetamol and caffeine 0.05 g;

     Tomapirin X-pill containing acetylsalicylic acid and 0.25 grams of paracetamol and ascorbic acid to 0.2 g.

     Tablets containing atsetilsalitsilovuyu acid dose of more than 0,325 grams (0,4-0,5 g), are designed to use as painkillers and anti (per ivorevmaticheskih) funds; In doses 0,1-0,3-0, g-325 adults, primarily as antitromboticheskih (antiagregantnyh) means (hence, in particular, the name "Aspirin cardiovascular), and children as analgetiko- antipireticheskih funds.

Materials allowed to copy only with the active hyperlink to the handbook of medicines