ATSIKLOVIR (Aciclovir). 9 - (2-Gidroksi) etoksimetilguanin, or 2-amino-1 digidro-9- 9 - (2-hydroxy) etoksimetil-6 H purin-6- it.
Synonyms : Viroleks, Zoviraks, Asus loguanosine, Acyclovir, Cycloviran, Milavir, Virolex.
Protivoviru stratagem preparation particularly effective against herpes viruses simple and herpes zoster (stripping).
Vacyclovir is similar purinovogo nukleozida dezoksiguanidina, the normal component of DNA.
Similar structures edition to edition and dezoksiguanidina with viral enzymes, leading to the interruption of virus reproduction. After introducing edition of herpes box stung by timidinkinazy allocated virus Model becomes atsiklovir- monofosfat which enzymes master cells into atsiklovir- diphosphate, and then in active atsiklovir- trifosfat that blocks the implementation of viral DNA. The drug acts selectively on the synthesis of viral DNA. At the DNA replication hoeyaina cells (a human cell) atsiklovir- trifosfat virtually no effect.
Vacyclovir with herpes prevents new elements disease, reduces the likelihood of skin disseminatsii and emerging complications accelerates education crusts, eases pain in the acute phase of herpes zoster.
The drug has also immunostimulating effect.
Model applied intravenously, the interior and local (as a cream or ointment).
When ingestion, Model absorbed only partially (about 20%). The half when administered and the introduction of non-about 3 hours Provided mainly kidneys unchanged, partly in the form of metabolite (9-karboksimetoksimetilguanin). In renal failure increases the half (19, 5 h).
Intravenous impose edition with infection caused with herpes simplex virus in patients with immune system disorders; With heavy form of primary infections of the reproductive organs in the event due to infection with herpes simplex virus; When infection caused by the herpes zoster virus; To prevent infections caused with herpes simplex virus in patients with severe immune dysfunction (with organ transplants, chemotherapy tumors).
Intravenous introduce adults and children over 12 years of age to 5 mg / kg 3 times a day (every 8 h); Herpes zoster in patients with immune system disorders, and 10 mg / kg every 8 hours; Children from 3 months to 12 years - 5 mg / kg (250 mg / m 2 body surface).
When violations renal excretory function and the elderly reduce the dose (with the withdrawal creatinine).
For intravenous content with aciclovir 1 capsules (250 mg) in 10 ml grow isotonic sodium chloride solution or special solvent. The solution can be administered in the form of injections slowly (one hour) or a drip, which gained solution (25 mg in 1 mL) to throw more in 50 mL solvent [or the contents of two vials (500 mg) Model to throw in 100 ml of solvent].
Apply to freshly solutions.
Pills edition designate infection in the skin and mucous membranes caused with herpes simplex virus, and for the prevention of these diseases in patients with immune system disorders and in patients got away with a normal immune system.
Adults with the infection caused with herpes simplex virus, are on one pill (0.2 g) five times a day (except for the night), and to prevent on-one tablet four times a day; While denying daily-to 4 tablets (0 , 8 g) five times a day.
Children older than 2 years are designated adult dose; Until two years - half the adult dose.
This treatment is usually five days, with herpes zoster another 3 days after the disappearance of the disease. Impose new drug is not recommended.
Oseltamivir with organ transplants and other diseases edition of the long duration of the risk is defined (usually six weeks).
Eye Model ointment applied to keratite investigated. Konyunktivalny bag in a 5 times a day at intervals of 4 hours usually within 7 to 10 days (for another three days to heal).
Crem apply to infection skin and mucous membranes caused with herpes simplex virus, and herpes lips, genitals. Bears stung on the surface 5 times a day (after 4 h). Duration of treatment 5 to 10 days.
Vacyclovir usually well. When ingestion possible nausea, vomiting, diarrhea, headaches, allergic skin reactions, increased fatigability, and when intravenously administered and the increase of urea, creatinine and cium in blood serum, the increased activity of liver enzymes.
If your solutions edition of subcutaneous fat fibre, a local reaction.
Contraindications : neperenosimost individual.
Admissibility of pregnancy and lactation have not been sufficiently studied.
Method of issuance : in bottles of 0.25 g (250 mg) in a package of five bottles; Tablets of 0.2 g (200 mg) in a package of 20 and 100 pieces; 3% eye ointment (30 mg in 1 g) in tubes of 4, 5 or 5 g; 5% cream (50 mg in 1 g) in the box on the city of 5
Storage : List B.
Materials allowed to copy only with the active hyperlink to the handbook of medicines