ATSEBUTOLOL (Acetolol).

     (±) N [3-Atsetil-4- [oksi-3- 2-[(1-methylethyl) amino] propoksi] phenyl] butanamida hydrochloride.

     SINONIMY : Atsekor, Sektral, Sectral.

     White or almost white powder. Well soluble in water, lower in alcohol.

     Kardioselektivny? 1-blockers. Has partial agonisticheekoy and stabilising activity.

     Completely absorbed in the digestive tract, bioavailability of approximately 40%, due to the effect of "first pass" through the liver (the active metabolite formed diatsetolol); C max-2.5 h, T1 / 2-hour 12-16; Presented with urine and faeces mostly as diatsetolola.

     Applied mostly with arterial hypertension, strokes, and nadzheludochkovyh zheludochkovyh tahiaritmiyah.

     It may also be used in heart attack, gipertroficheskoy cardiomyopathy, tremor and thyrotoxicosis.

     Assign the interior of 0.2 g, 2 times a day, with neobhrdimosti daily dose increased to 0,8-0,9 city

     Antihypertensive effect usually develops through 1.5 h after administration, reaches through 3-8 hrs and continued until 24-30 hours

     Possible side effects, contraindications and limitations to the use of the same as the anaprilina and atenolol.

     FORM OUTPUT : pills for 0.2 and 0.4 g (N. 15, 20, 30).

     STORAGE : List B.

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