ATSEDIPROL (Acediprolum).

     Sodium salt of 2-propilvalerianovoy acid :

     Synonyms : Apilepsin, Depakin, Konvuleks, Apilepsin, Convulex, Convulsovin, Depaken, Depakin, Deprakine, Diplexil, Epikine, Epilim, Everiden, Leptilan, Orfilept, Orfiril, Propymal, Valpakine, Valporin, Valprin, Valproate sodium, Valpron etc.

     Atsediprol melkokristallichesky white powder, easily soluble in water and alcohol.

     Is antiepileptic of broad-spectrum. The drug is readily absorbed when administered. Peak concentrations in plasma observed in 2 hours The half was approximately 8 h. Provided mainly in the form of urine Algae or oxidation products.

     Applied in adults and children with different types of epilepsy : the various forms of generalized fits-small (absansah), large (cramps) and polymorphic; When focal tachycardia (motor, psychomotor, etc.). Preparation is the most effective for absansah and visochnyh psevdoabsansah.

     Is atsediprol inside during or immediately after eating. Beginning with the admission of small doses, gradually increasing to within 1 - 2 weeks before the therapeutic effect; Then choose individual dose supportive.

     Daily intake for adults is in the early treatment of 0,3 - 0,6 g (1 - 2 pills), then gradually increase to 0.9 to 1, 5 g. Under the dose 0.3 - 0.45 g. The highest daily dose 2, 4 g.

     Doses for children are picked individually, depending on age, severity of illness, therapeutic effect. Usually daily intake for children is 20 to 50 mg per 1 kg of body weight, the highest daily 60 mg / kg. Started treatment with 15 mg / kg, then weekly dose increase of 5 to 10 mg / kg to achieve the necessary effect. The daily dose divided into 2 - 3 admission. Children easily assign product in the form of liquid medicinal form-syrup atsediprola 5% (Sirupus Acediproli 5%), containing 1 ml of 50 mg drug. Number syrup otmerivayut low spoons with division 2, 5 and 5 ml.

     Atsediprol can be used alone or in combination with other drugs protivoepilepticheskimi.

     In small forms of epilepsy are normally restricted to use only atsediprola.

     Atsediprol has not only protivosudorozhnoe (antiepilepticheskoe) effect. It also improves mood and mental patients. Showing having valproata sodium trankviliziruyuschego component, unlike other tranquilizers it, reducing the fear is not having somnolentnogo, sedated and miorelaksantnogo action.

     The experimental data, antiaritmicheskoy drug's activity, due apparently activated central stresslimitiruyuschey GAMKergicheskoy braking system, as well as direct kardiotropnym action.

     Possible side effects : nausea, vomiting, diarrhea, stomach pain, anorexia or increased appetite, mood, allergic skin reactions. Typically, these effects are temporary, may be weakened or removed appointments during food preparation, the steady increase doses of spazmolitikov, mats or anti funds.

     With a long reception of large doses atsediprola possibly temporary hair loss.

     Rare, but the most serious adverse reactions to atsediprol a disruption of the liver, pancreas and declining blood coagulability. Gepatotoksichesky effect is more likely in the joint appointment atsediprola with phenobarbital, difeninom, carbamazepine, clonazepam. The prevention of severe complications should be carefully monitored as the liver, pancreas, blood svertyvannya system. Before treatment, while increasing doses, as well as every 2 to 3 months maintenance determine the content of serum liver enzymes, cium; Counting produce platelets.

     Particular scrutiny require patients previously undergone liver disease and pancreas. Atsediprol may exacerbate the effects of other protivoepilepticheskih (difenina etc.), antidepressants, Neuroleptics. Therefore, if necessary, to reduce the dose of these drugs.

     Anticoagulants, acetylsalicylic acid and atsediprol reinforcing the inhibitive effect on the aggregation of platelets, which requires strict monitoring of blood coagulation system, while the application of these drugs.

     The drug may cause a general phenomenon of oppression and fatigue. This should be taken into account when appointing people, doing hard physical and mental work. When treating atsediprolom no admission of alcohol.

     Please note that diabetics atsediprol can distort the analysis of urine, increasing content ketonovyh tel.

     The drug is contraindicated in violation of the functions of liver and pancreas, hemorrhagic diathesis. Nor should designate product in the first three months of pregnancy (later appointed to the reduced dose and only with inefficiencies protivoepilepticheskih other means). The literature shows the cases teratogennogo effect in the application valproata sodium during pregnancy. It should also be borne in mind that the product is milk in lactating women.

     Method of issuance : pills to 0.3 grams (with risk) in a package of 50 and 100 pieces; 5% syrup (colourless or poor-yellow transparent thick liquid sweet taste from sugar and edible fluids) in glass bottles of 120 ml of applications dispensing spoons.

     Storage : List B. In the dark cool place.

     Various foreign firms product produced in the form of tablets (thickly coated, soluble in the gut), containing 150; 200 or 300 mg valproevoy valproata acid or sodium and 500 mg (depakin-500); A capsules of 150 and 300 mg ; as syrup (cough), containing 50 mg sodium valproata in 1 ml and 300 mg in 1 ml.

     Konvuleks issued in the form of <Enterokapsul> containing 0.15 or 0.3 g valproevoy acid.

     Konvulsofin (Convulsofin) and some other drugs are calcium salts valproevoy acid.

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