Universal reference book for medicines
Product name: EVICT (EVICT)

Active substance: lactulose

Type: Laxative with osmotic properties.
Hypoammonemic means
Manufacturer: ALBERT DAVID (India) manufactured by D.GUPTA LANE (India)
Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..

PHARMACHOLOGIC EFFECT
Laxative.
It causes a change in the flora of the colon (an increase in the number of lactobacilli), which leads to an increase in acidity in the lumen of the colon and stimulates its peristalsis. Along with this, the volume increases and the feces softens. As a result, a laxative effect develops, without direct influence on the mucosa and smooth musculature of the large intestine. Under the influence of lactulose, there is also absorption of ammonia in the large intestine, a decrease in the formation of nitrogen-containing toxic substances in its proximal part and, accordingly, their absorption into the vena cava system. Has the ability to inhibit the growth of salmonella in the colon. Does not reduce the absorption of vitamins and is not addictive. Virtually not absorbed from the intestine.
PHARMACOKINETICS
After oral administration of lactulose by passage passes into the large intestine, where it is metabolized by bacteria that break down the sugar.
As a result, simple organic acids are formed, mainly lactic acid and, to a lesser extent, acetic and formic acid. A small amount of lactulose is absorbed and excreted in the urine unchanged.
INDICATIONS
Constipation, incl.
chronic, with pregnancy, hemorrhoids; after surgical interventions on the large intestine and / or in the anal area, to prepare for surgical interventions on the large intestine; for softening of the stool (relief of defecation) with pain syndrome after removal of hemorrhoids; hepatic encephalopathy; hepatic precoma and coma.
DOSING MODE
Individual, depending on age and indications.

SIDE EFFECT
From the digestive system: in the first days of admission, the appearance of flatulence is possible (usually gradually decreases and passes);
when taken in doses exceeding the recommended, there may be pain in the abdomen and diarrhea, which requires dose adjustment; rarely - nausea.
When used in high doses for a long time for the prevention and treatment of hepatic precoma and coma, diarrhea and disturbance of water-electrolyte metabolism are possible.

From the nervous system: rarely - convulsions, headache, dizziness.

Other: possibly - allergic reactions;
rarely - arrhythmia, myalgia, fatigue, weakness.
CONTRAINDICATIONS
Rectal bleeding;
colo-, ileostomy; suspicion of appendicitis; galactosemia; patients with lactose intolerance, lactase deficiency, glucose-galactose malabsorption;intestinal obstruction; hypersensitivity to lactulose.
PREGNANCY AND LACTATION
Possible use in pregnancy and lactation (breastfeeding) according to indications.

SPECIAL INSTRUCTIONS
Do not use for pain in the abdomen, nausea, vomiting without verification of the diagnosis.

Use with caution in patients with gastro-cardial syndrome.
In such cases, treatment should begin with low doses and increase them gradually to avoid the development of flatulence.
Use with caution in patients with diabetes mellitus, especially with inflammatory bowel disease.

With prolonged treatment (more than 6 months), the level of potassium, chlorine and carbon dioxide in the blood plasma should be regularly monitored.

If diarrhea occurs, you should stop taking lactulose.

DRUG INTERACTION
At simultaneous application with antibiotics of a wide spectrum of action reduction of therapeutic efficiency of a lactulose is possible.

With the simultaneous use of lactulose, it can disrupt the release of active substances from enteric-soluble drugs with pH-dependent release, because it lowers the pH of the intestinal contents.

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