Universal reference book for medicines
Product name: EX-LAX (EX-LAX)

Active substance: sennosides

Type: Laxative drug that stimulates intestinal motility

Manufacturer: NOVARTIS CONSUMER HEALTH (Switzerland) manufactured by NOVARTIS EX-LAX (Puerto Rico)
Composition, form of production and packaging
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The chewing lozenges are rectangular in shape, dark brown in color, with the inscription "ex-lax" on one side, the lozenges are formed into a rectangular shaped tile of 9 or 12 pieces.
1 loaf

sennosides A and B 15 mg

Auxiliary substances: sucrose, cocoa beans (powder), skimmed milk powder, hydrogenated palm oil, lecithin.

9 pcs.
(tiles) - aluminum foil (2) - packs of cardboard.
12 pcs.
(tiles) - aluminum foil (1) - packs of cardboard.
12 pcs.
(tiles) - aluminum foil (2) - packs of cardboard.
INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2014.

PHARMACHOLOGIC EFFECT

Laxative means of plant origin (the sum of antraglikozidov from the leaves of Senna, cassia holly and narrow-leaved).
It causes irritation of the intestinal mucosa, reflexively enhances peristalsis, which leads to a faster evacuation of the intestine. Not addictive and does not affect digestion. The action occurs 8-12 hours after admission.
PHARMACOKINETICS

Sennosides are beta-glycosides that are not absorbed in the upper intestine and are not digested by digestive enzymes.
They are converted by colon bacteria into active metabolites (rinsantrons) that are absorbed in the upper intestine. When reacting with oxygen, reynanthrons are oxidized to rsin and sennidines, which can be detected in the bloodstream mainly in the form of glucuronides and sulphates. After oral administration of sennosides, approximately 3% of their metabolites are excreted in the urine, some with bile.
Most sennosides (about 90%) are excreted in feces in the form of polymers (polyquinones), together with 20% of unchanged sennosides, sennidines, reynanthron and rhein.
A small amount is excreted in breast milk.
INDICATIONS

- Constipation (hypo- and atony of the gastrointestinal tract, flaccid peristalsis of the colon, including after operations, delivery);

- Preparation for X-ray studies.

DOSING MODE

Inside.
Pastilles Ex-lax should be chewed and swallowed.
Adults and children over 12 years: 2 lozenges 1-2 times a day.
The maximum allowable daily dose is 4 lozenges.
Children from 6 to 12 years: 1 lozenge 1-2 times a day.
The maximum allowable daily dose is 2 lozenges. Do not take the drug for more than 7 days without consulting a doctor.
SIDE EFFECT

Discomfort in the abdominal region, for example, spasms, irritation of the mucous membrane of the stomach and intestines, flatulence, nausea.
Also possible hypotension, fatigue, myopathy, abdominal pain, disturbance of water-electrolyte metabolism (excessive removal of water and salts from the body), renal dysfunction, secondary hyperaldosteronism, hypocalcemia, hypomagnesemia, fatigue, confusion, skin rash, diarrhea, convulsions, cardiovascular collapse.
It is also often observed a change in the color of urine (which has no clinical significance) and is habituated to long-term use of the drug.

CONTRAINDICATIONS

- hypersensitivity to the components of the drug;

- intestinal obstruction;

- strangulated hernia;

- Acute inflammatory diseases of the abdominal cavity (including peritonitis);

bleeding from the gastrointestinal tract;

- Metrorrhagia;

- Cystitis;

- spastic constipation;

- violation of water-electrolyte exchange;

lactose intolerance;

- Lactase insufficiency;

- glucose-galactose malabsorption;

- Children's age (up to 6 years).

With caution: pregnancy, lactation, hepatic and / or renal failure;
a condition after cavitary operations, at a diabetes mellitis in connection with presence in a preparation of sucrose.
PREGNANCY AND LACTATION

With caution during pregnancy and lactation.

APPLICATION FOR FUNCTIONS OF THE LIVER

With caution in kidney failure.

APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS

With caution in liver failure.

APPLICATION FOR CHILDREN

Contraindicated up to 6 years.

SPECIAL INSTRUCTIONS

Treatment should begin with a minimum effective dose, which leads to normal functioning of the intestine.
Prolonged messy use of laxatives can lead to a disruption of the function of the gastrointestinal tract.
The drug should be taken 2 hours after taking other medications.
If there is no laxative effect after taking the recommended doses, you should consult your doctor.
If there is no laxative effect or if you need to take the drug for more than 1 week, you should also consult a doctor.

Care should be taken when there is milk intolerance in the anamnesis, because
the preparation contains milk powder.
Due to the presence of sucrose in the composition of the drug, people suffering from diabetes mellitus, as well as having carbohydrate metabolism, such as intolerance to fructose, impaired absorption of glucose and galactose, insufficiency of isomaltase sucrose, Exxon should be taken with caution.
The content of sucrose in 1 loaf is 474.12 mg, in terms of bread units is equivalent to 0.04 XE.
OVERDOSE

Symptoms: increased side effects.

Treatment: symptomatic.

DRUG INTERACTION

When combined, the drug reduces the concentration of quinidine in the blood plasma.

In the case of simultaneous use of cardiac glycosides, antiarrhythmics, diuretics and glucocorticosteroids, there is a high risk of hypokalemia, which can lead to disruption of the heart or neuromuscular transmission.

The drug may interfere with the absorption of tetracyclines.

Acceptance of the drug may distort the results of urine analysis due to a change in its color.

TERMS OF RELEASE FROM PHARMACY

Without recipe.

TERMS AND CONDITIONS OF STORAGE

At a temperature of no higher than 25 ° C.
Keep out of the reach of children. Shelf life - 3 years.
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