Universal reference book for medicines
Name of the preparation: EXIFIN® (EXIFINE)

Active substance: terbinafine

Type: Antifungal medication for external use

Manufacturer: DR.
REDDY`S LABORATORIES (India)
Composition, form of production and packaging
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Cream for external use 1% 1 g
terbinafine hydrochloride 10 mg

Auxiliary substances: benzyl alcohol 10 mg, purified water 718 mg, isopropyl myristate 80 mg, sodium hydroxide 2 mg, polysorbate 60-61 mg, sorbitan monostearate 19 mg, stearyl alcohol 40 mg, cetyl alcohol 40 mg, cetyl palmitate - 20 mg.

10 g - aluminum tubes (1) - packs of cardboard.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2011.

PHARMACHOLOGIC EFFECT

Antifungal agent for topical use, with a wide range of antifungal activity.
At low concentrations, terbinafine has fungicidal activity against dermatophytes (Trychophyton rubrum, Trychophyton mentagrophytes, Trychophyton verritcosum, Trychophyton violaceum, Trychophyton tonsurans, Microsporum canis, Epidermophyton floccosum), molds and certain dimorphic fungi (Pityrosporum orbiculare). Activity in relation to
yeast is fungicidal or fungistatic in nature depending on the type of fungi.

Terbinafine, by inhibiting squalene epoxidase in the cell membrane of the fungus, specifically suppresses the early stage of sterol synthesis in the fungal cell, which leads to ergosterol deficiency, intracellular squalene accumulation and fungal cell death.
Squalene-epoxidase is not associated with the cytochrome P450 system, so terbinafine does not affect the metabolism of hormones and drugs whose metabolism is associated with the cytochrome P450 system.
PHARMACOKINETICS

With topical application, absorption - less than 5%, has a minor systemic effect.

INDICATIONS

Prevention and treatment of fungal diseases of the skin:

- Trichophytosis, microsporia, rubrofitia, caused by sensitive pathogens, incl.
foot mycoses and inguinal epidermophyty;
yeast infections (skin candidiasis);

- colored lichen.

DOSING MODE

Outwardly.
Before applying Exxin, it is necessary to clean and dry the affected areas. The cream is applied a thin layer on the affected skin and adjacent areas and lightly rubbed. In infections accompanied by intertrigo (under the mammary glands, in the interdigital spaces, between the buttocks, in the groin area), the places of application of the cream can be covered with gauze, especially at night.
Average duration and frequency of application:

Dermatomycosis of the trunk, drumsticks -1 week 1 time / day;

Inguinal epidermophytosis - 1-2 weeks 1 time per week.

Dermatomycosis of the feet - 1 week 1 time per day.

Candidiasis of the skin - 1-2 weeks 1 or 2 times / day.

Multicolored lichen - 2 weeks 1 or 2 times / day.

The duration of treatment depends on the indication and severity of the disease.
Reduction in the severity of clinical manifestations is noted in the first days of treatment. "
For the prevention of relapses mycosis stop - 2-3 courses for 2 weeks with a break of 7 days.

Dosage regimen of the drug Exifin in the elderly does not differ from the above.

SIDE EFFECT

Itching and burning of the skin, hyperemia in the place of application.

CONTRAINDICATIONS

- Hypersensitivity to the components of the drug.

With caution: hepatic and / or renal insufficiency;
alcoholism; oppression of bone marrow hematopoiesis; tumors; metabolic diseases; occlusive diseases of the vessels of the extremities, psoriasis, pregnancy, lactation period, children under 12 years of age (lack of sufficient clinical experience of application).
PREGNANCY AND LACTATION

With caution in pregnancy and lactation.

APPLICATION FOR FUNCTIONS OF THE LIVER

Carefully.

APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS

Carefully.

APPLICATION FOR CHILDREN

With co-generation:

APPLICATION IN ELDERLY PATIENTS

Older patients are prescribed in the same vines as adults.

SPECIAL INSTRUCTIONS

Reducing the severity of clinical manifestations is usually noted in the first days of treatment.

Irregular application or early termination of treatment increases the risk of relapse.

If after 2 weeks.
there is no improvement in the condition, it is necessary to repeatedly identify the causative agent of the disease and its sensitivity to the drug.
In the process of treatment, it is necessary to follow the general rules of hygiene to prevent re-infection (through underwear, shoes).

Avoid getting the cream in the eyes and the mucous membrane of the nasal cavity, mouth.

Impact on the ability to drive vehicles and manage mechanisms

The drug has a minor systemic effect, so it is unlikely to influence the driving of vehicles and other potentially hazardous activities requiring increased concentration of attention and speed of psychomotor reactions.

OVERDOSE

In case of external use, an overdose is unlikely.

Symptoms of accidental ingestion: headache, nausea, gastralgia, dizziness, frequent urination, rash.

Treatment: activated charcoal, if necessary - symptomatic maintenance therapy.

DRUG INTERACTION

Any drug interactions for Exifin are not known.

TERMS OF RELEASE FROM PHARMACY

The drug is approved for use as a means of OTC.

TERMS AND CONDITIONS OF STORAGE

Keep out of the reach of children at a temperature of up to 25 ° C.
Do not freeze. Shelf life - 3 years.
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