Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..
PHARMACHOLOGIC EFFECT
Antifungal agent of the group of allylamines. It acts by suppressing squalene epoxidase in the cell membrane of the fungus. This leads to a deficiency of ergosterol and to intracellular accumulation of squalene, which causes the death of the cell of the pathogen.
It has a fungicidal effect on dermatophytes, molds and some dimorphic fungi, yeast and yeast-like fungi. Some types of yeasts can act fungistatically.
It is active against pathogens of dermatomycosis (Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Trichophyton verrucosum, Trichophyton violaceum), as well as Microsporum canis and Epidermophyton floccosum; yeast-like fungi of the genus Candida (mainly Candida albicans); the causative agent of a colored lichen (Malassezia furfur).
PHARMACOKINETICS
After oral administration, it is well absorbed from the digestive tract. Binding to plasma proteins - 99%. Terbinafine diffuses through the dermal layer of the skin and accumulates in the lipophilic stratum corneum, is secreted into the skin fat, resulting in high concentrations in the hair follicles, nails. During the first few weeks after the start of the treatment terbinafine accumulates in the skin and nail plates in concentrations that provide fungicidal action. Metabolized in the liver with the formation of inactive metabolites. It is excreted in the urine, mainly in the form of metabolites. T 1/2 - 17 h.
INDICATIONS
For oral administration: fungal skin lesions caused by dermatophytes - trichophytosis, epidermophytosis, microsporia, fungal nail infections (onychomycosis), candidiasis.
For external use: fungal skin lesions caused by dermatophytes, candidiasis; colored lichen.
DOSING MODE
Inside adults - 250 mg / day in 1 or 2 admission. The duration of treatment depends on the indications and severity of the infection: with skin lesions - 2-4 weeks, with nail damage - from 6 weeks. up to 4 months or more. Children with a body weight of more than 40 kg - 250 mg / day, 20-40 kg - 125 mg / day, up to 20 kg - 62.5 mg / day.
External apply 1-2 times / day for 1-2 weeks.
SIDE EFFECT
On the part of the digestive system: nausea, anorexia, mild abdominal pain, diarrhea, impairment or loss of taste sensations, cholestasis, jaundice, hepatitis.
Allergic reactions: skin rash; rarely - arthralgia, myalgia, erythema multiforme, Stevens-Johnson syndrome.
From the side of the central nervous system: a headache.
From the side of the hematopoiesis system: neutropenia, thrombocytopenia.
Local reactions: hyperemia, itching, burning sensation.
CONTRAINDICATIONS
Hypersensitivity to terbinafine.
PREGNANCY AND LACTATION
The experience with terbinafine during pregnancy is limited. If necessary, the appointment in the lactation period should resolve the issue of stopping breastfeeding.
APPLICATION FOR FUNCTIONS OF THE LIVER
It should be used with caution terbinafine for oral administration in patients with impaired renal function.
APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS
It should be used with caution terbinafine for oral administration in patients with impaired liver function.
APPLICATION FOR CHILDREN
The application is possible according to the dosing regimen.
APPLICATION IN ELDERLY PATIENTS
Terbinafine should be used with caution in the elderly.
SPECIAL INSTRUCTIONS
It should be used with caution terbinafine for oral administration in patients with impaired liver and / or kidney function, as well as in the elderly.
DRUG INTERACTION
Drugs that induce the induction of microsomal liver enzymes increase the terbinafine clearance; drugs that inhibit microsomal enzymes of the liver - reduce the terbinafine clearance.
