Universal reference book for medicines
Product name: CEFOXYTIN (CEFOXITIN)

Active substance: cefoxitin

Type: Cephalosporin II generation

Manufacturer: Company DEKO (Russia)
Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..

PHARMACHOLOGIC EFFECT
Cephalosporin antibiotic of the second generation of a broad spectrum of action.
Has a bactericidal effect.
Highly active against gram-negative bacteria: Haemophilus influenzae, Escherichia coli, Salmonella spp., Shigella spp., Enterobacter spp., Proteus mirabilis, Neisseria gonorrhoeae;
Gram-positive bacteria: Staphylococcus spp., Streptococcus spp .; anaerobic bacteria: Bacteroides spp.
Inactive against Pseudomonas spp., Most strains of Enterococcus spp., Many strains of Enterobacter cloacae, methicillin-resistant strains of Staphylococcus spp.
and Listeria monocytogenes.
Resistant to the action of? -lactamases.

INDICATIONS
Infectious-inflammatory diseases caused by microorganisms sensitive to cefoxytin, incl.
abdominal and gynecological infections, sepsis, endocarditis, urinary tract infections, respiratory tract, bones and joints, skin and soft tissues. Mixed infections caused by sensitive strains of aerobic and anaerobic bacteria. Prevention of postoperative infectious complications.
DOSING MODE
Established individually, taking into account the severity of the course and localization of infection, the sensitivity of the pathogen.
Enter in / m or in / in (struyno or drip). The average dose for adults is 1-2 g every 8 hours. In severe infections, the daily dose can be increased to 200 mg / kg (but not more than 12 g). If there is a violation of the excretory function of the kidneys, the first dose is 1-2 g, and in the future it is necessary to reduce the single dose and increase the intervals between the administrations.
For children, a single dose is 20-40 mg / kg;
the interval between administrations for premature infants with a body weight of 1500 g and newborns of the first week of life is 12 hours, for infants 1-4 weeks of life - 8 hours, for more than 1 month - 6-8 hours.
For the prevention of postoperative infections, adults are injected 0.5-1 h before the commencement of the operation, 2 g IM or IV;
after the operation - 2 g every 6 hours during the first day. Children are injected at 30-40 mg / kg at the same intervals, but newborns are given the second and third doses in 8-12 hours. When conducting cesarean section after clamping the umbilical cord is injected simultaneously in / in 2 g.
SIDE EFFECT
With prolonged use in high doses : nausea, vomiting, dry mouth, loss of appetite, diarrhea, skin allergic reactions, arterial hypotension;
rarely - pseudomembranous colitis, changes in the pattern of peripheral blood (leukopenia, neutropenia, thrombocytopenia), anemia (including hemolytic), transient increase in the concentration of liver enzymes in the blood, impaired renal function.
CONTRAINDICATIONS
Hypersensitivity to cephalosporins.

PREGNANCY AND LACTATION
Application in pregnancy and lactation is possible only in cases of extreme necessity, when the intended benefit to the mother exceeds the potential risk to the fetus or the child.

APPLICATION FOR FUNCTIONS OF THE LIVER
With caution apply for severe impairment of kidney function.

APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS
With caution apply for severe violations of liver function.

APPLICATION FOR CHILDREN
The application is possible according to the dosing regimen.

SPECIAL INSTRUCTIONS
In patients with hypersensitivity to penicillins, allergic reactions to cephalosporin antibiotics are possible.

Cefoxytin is not recommended for the treatment of meningitis.

Use with caution in severe impairment of kidney and / or liver function.

During the treatment, a positive direct Coombs reaction is possible.

TERMS AND CONDITIONS OF STORAGE
OS for Kazakhstan

Alphabetical index of medicines:
A  B  V  G  D  E  J
Z  I  Y  K  L  M  N
O  P  R  S  T  U  F
H  C  CH  SH  E  U  Y
Rambler's Top100
Privacy policy:
Copyright 2009 - 2017. Universal reference book of medicines. All rights reserved.
When using site materials, an active hyperlink is required!