Universal reference book for medicines
Product name: CEFAZOLIN-AKOS (CEFAZOLIN-AKOS)

Active substance: cefazolin

Type: 1st generation cephalosporin

Manufacturer: SYNTHESIS (Russia)
Composition, form of production and packaging
Powder for preparation of a solution for iv and in / m introduction
white or white with a yellowish shade of color.

1 f.

cefazolin (in the form of the sodium salt) 500 mg

Vials with a volume of 10 ml (1) - packs of cardboard.

Vials with a volume of 10 ml (10) - packs of cardboard.

Vials with a volume of 10 ml (50) - packs of cardboard.

Powder for preparation of a solution for iv and in / m introduction white or white with a yellowish shade of color.

1 f.

cefazolin (in the form of the sodium salt) 1 g

Vials with a volume of 10 ml (1) - packs of cardboard.

Vials with a volume of 10 ml (10) - packs of cardboard.

Vials with a volume of 10 ml (50) - packs of cardboard.

Powder for the preparation of solution for the / m introduction of white or white with a yellowish hue.

1 f.

cefazolin (in the form of the sodium salt) 500 mg

Vials with a volume of 10 ml (1) - packs of cardboard.

Vials with a volume of 10 ml (10) - packs of cardboard.

Vials with a volume of 10 ml (50) - packs of cardboard.

Powder for the preparation of solution for the / m introduction of white or white with a yellowish hue.

1 f.

cefazolin (in the form of the sodium salt) 1 g

Vials with a volume of 10 ml (1) - packs of cardboard.

Vials with a volume of 10 ml (10) - packs of cardboard.

Vials with a volume of 10 ml (50) - packs of cardboard.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2005.

PHARMACHOLOGIC EFFECT

Semisynthetic cephalosporin antibiotic of the 1st generation of a wide spectrum of action for parenteral administration.
It acts bactericidal, suppressing the biosynthesis of the bacterial cell wall. It is active against gram-positive bacteria: Staphylococcus spp. (with the exception of methicillin-resistant strains), Streptococcus spp. (with the exception of Streptococcus faecalis); Gram-negative bacteria: Escherichia coli, Proteus mirabilis, Klebsiella spp., Neisseria gonorrhoeae, Treponema spp., Enterobacter aerogenes, Haemophilus influenzae.
Indole-positive strains of the protein, Pseudomonas aeruginosa, are resistant to the drug.

PHARMACOKINETICS

Suction

With the / m and / in the introduction of the drug is quickly distributed in the tissues and body fluids.
C max is achieved after 1 hour. Therapeutic concentrations are maintained for 8-12 hours.
Distribution and deduction

Cefazolin easily penetrates the placental barrier, into the synovial, pleural and peritoneal fluid.

It is excreted by the kidneys, creating a high concentration in the urine.

INDICATIONS

- sepsis;

- peritonitis;

- endocarditis;

- respiratory tract infections;

- urinary tract infections;

- syphilis;

- Gonorrhea;

- infections of bones and joints;

- prevention of postoperative complications.

DOSING MODE

The drug is given in / m and / in (strujno and drip).
With the / m introduction, a single dose for adults is 0.25-1 g every 8-12 hours. The average daily dose is 0.75-1.5 g.
In severe infections, appoint 0.5-1 g every 6-8 hours. The maximum daily dose is 6 g.

For prophylaxis of postoperative complications, 1 g is administered 30 minutes before the operation, 0.5-1 g during the operation and 0.5-1 g every 6-8 hours during the day after the operation.

Children over 1 month are prescribed in a daily dose of 25-50 mg / kg, with severe infections - 100 mg / kg.
The daily dose is divided into 2-3 doses.
When prescribing the drug, it is necessary to determine the sensitivity of the isolated pathogens to it using discs containing 30 μg of cefazolin.

When violations of the excretory function of the kidney in adults, the dose of the drug is reduced, the intervals between the administrations are increased.
The initial dose is 500 mg, regardless of the degree of renal dysfunction.
The duration of treatment is 7-14 days or more, depending on the severity of the disease.

Rules for the preparation of solution

To prepare the solution for the / m introduction to the contents of the vial (500 mg or 1 g) add 2-3 ml of water for injection.

To prepare a solution for intravenous administration, the contents of the vial (500 mg or 1 g) are dissolved in 10 ml of 0.9% sodium chloride solution.

To prepare a solution for IV infusion, the contents of the vial (500 mg or 1 g) are dissolved in 100-150 ml of 0.9% sodium chloride solution or 5% glucose solution.

SIDE EFFECT

Allergic reactions: skin rash, itching, eosinophilia.

From the side of the urinary system: in patients with renal failure with the use of the drug in large doses (6 g), renal failure may develop.

Local reactions: with iv injection, phlebitis.

Other: gastrointestinal disorders, dysbiosis, superinfection caused by antibiotic-resistant strains.

CONTRAINDICATIONS

- hypersensitivity to cephalosporins;

- Pregnancy;

- age up to 1 month.

PREGNANCY AND LACTATION

The drug is contraindicated for use in pregnancy.

Low concentrations of cefazolin are found in breast milk.

The use in the period of lactation is justified only in those cases when the prospective benefit for the mother exceeds the potential risk for the child.

APPLICATION FOR FUNCTIONS OF THE LIVER

When violations of the excretory function of the kidney in adults, the dose of the drug is reduced, the intervals between the administrations are increased.
The initial dose is 500 mg regardless of the extent of renal dysfunction

APPLICATION FOR CHILDREN

The drug is contraindicated for children under 1 month.

Children over 1 month are prescribed in a daily dose of 25-50 mg / kg, with severe infections - 100 mg / kg.
The daily dose is divided into 2-3 doses.
SPECIAL INSTRUCTIONS

With the development of allergic reactions, the drug should be discontinued and appropriate desensitizing therapy should be prescribed.

With the development of renal failure, the dose of the drug should be lowered and the treatment should be further controlled by the dynamics of urea nitrogen and creatinine in the blood.

It is not recommended to prescribe the drug simultaneously with anticoagulants and diuretics (furosemide, ethacrynic acid).

OVERDOSE

At present, no cases of an overdose of Cefazolin-AKOS have been reported.

DRUG INTERACTION

Synergism of antibacterial action is noted while using the drug with aminoglycosides, vancomycin, rifampicin.

TERMS AND CONDITIONS OF STORAGE

List B. The drug should be stored in a dry, protected from light at a temperature of no higher than 5 ° C.
Shelf life - 3 years.
The prepared injection solution is suitable for use for 24 hours at a temperature of no higher than 25 ° C.

Conditions of leave from pharmacies

The drug is released by prescription.

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