Universal reference book for medicines
Product name: CETYL LUPIN (CETYL LUPIN)

Active substance: cefuroxime

Type: Cephalosporin II generation

Manufacturer: LUPIN (India)
Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..

PHARMACHOLOGIC EFFECT
Cephalosporin antibiotic of the second generation of a broad spectrum of action.
Has a bactericidal effect by inhibiting the synthesis of the bacterial cell wall.Cefuroxime acetylates membrane-bound transpeptidases, thereby violating the cross-linking of peptidoglycans necessary to ensure the strength and rigidity of the cell wall.
Highly active against Gram-negative bacteria: Escherichia coli, Haemophilus influenzae, Salmonella spp., Shigella spp., Proteus mirabilis, Neisseria gonorrhoeae, Enterobacter spp.

It is also active against gram-positive bacteria: Staphylococcus spp., Streptococcus spp.

Inactive against Pseudomonas spp., Most strains of Enterococcus spp., Many strains of Enterobacter cloacae, methicillin-resistant strains of Staphylococcus spp.
and Listeria monocytogenes.
Resistant to the action of? -lactamases.

PHARMACOKINETICS
Cefuroxime is rapidly absorbed from the digestive tract.
Binding to plasma proteins is 50%. Cefuroxime is distributed in tissues and body fluids. Therapeutic concentrations in the cerebrospinal fluid are reached only with meningitis. Penetrates through the placental barrier, excreted in breast milk. It is excreted unchanged in the urine.
INDICATIONS
Infectious-inflammatory diseases caused by microorganisms sensitive to cefuroxime, incl.
abdominal and gynecological infections, sepsis, meningitis, endocarditis, urinary tract infections, respiratory tract, bones and joints, skin and soft tissues. Prevention of postoperative infectious complications in operations on the organs of the abdominal cavity, small pelvis, heart, lungs, esophagus, vessels, and orthopedic operations.
DOSING MODE
Established individually, taking into account the severity of the course and localization of infection, the sensitivity of the pathogen.
Apply inside, in / m or / in. When administered orally, a single dose for adults is 250-500 mg, for children - 125-250 mg, the frequency of intake is 2 times / day.
For parenteral administration, a single dose for adults is 0.75-1.5 g 3 times / day.
Depending on the etiology of the disease, 1.5 g once or 750 mg 2 times with an interval of 8 hours are used. Children under the age of 3 months are 10-50 mg / kg / day, the frequency of administration is 2-3 times; over 3 months - 15-80 mg / kg / day, frequency of reference - 2-3 times.
Patients with renal dysfunction dosing regimen is set taking into account the CK values.

The maximum daily intake for adults is 6 g.

SIDE EFFECT
On the part of the digestive system: nausea, vomiting, diarrhea, transient increase in hepatic transaminase activity, cholestatic jaundice, hepatitis, pseudomembranous colitis.

Allergic reactions: skin rash, itching, eosinophilia;
rarely - angioedema.
From the hemopoietic system: with prolonged use in high doses, changes in the pattern of peripheral blood (leukopenia, neutropenia, thrombocytopenia, hemolytic anemia) are possible.

From the side of the blood coagulation system: hypoprothrombinemia.

From the side of the urinary system: interstitial nephritis.

Effects caused by chemotherapeutic action: Candidiasis.

Local reactions: phlebitis (with iv introduction), soreness at the injection site (with an / m introduction).

CONTRAINDICATIONS
Hypersensitivity to cefuroxime and other cephalosporins.

PREGNANCY AND LACTATION
Adequate and strictly controlled studies of the safety of cefuroxime during pregnancy have not been conducted.

The use of cefuroxime during pregnancy and during lactation is possible in cases where the intended benefit of therapy for the mother exceeds the potential risk to the fetus.

Cefuroxime excreted in breast milk.

In experimental animal studies, teratogenic and embryotoxic effects of cefuroxime were not detected.

APPLICATION FOR FUNCTIONS OF THE LIVER
Patients with renal dysfunction dosing regimen is set taking into account the CK values.

APPLICATION FOR CHILDREN
The application is possible according to the dosing regimen.

SPECIAL INSTRUCTIONS
Use with caution in cases of severe impairment of kidney function, with indications of colitis in the anamnesis.

With prolonged use, there may be a violation of normal intestinal microflora, which can lead to the growth of Clostridium difficile and cause the development of severe diarrhea and pseudomembranous colitis.

In patients with hypersensitivity to penicillins, allergic reactions to cephalosporin antibiotics are possible.

During treatment, a positive direct Coombs reaction and a false positive urine reaction to glucose are possible.

DRUG INTERACTION
Cefuroxime, suppressing the intestinal flora, interferes with the synthesis of vitamin K. Therefore, with the simultaneous use with drugs that reduce platelet aggregation (NSAIDs, salicylates, sulfinpyrazone), the risk of bleeding increases.
For the same reason, with simultaneous use with anticoagulants, there is an increase in anticoagulant activity.
With simultaneous use with "loop" diuretics, the risk of developing nephrotoxic action increases.

Alphabetical index of medicines:
A  B  V  G  D  E  J
Z  I  Y  K  L  M  N
O  P  R  S  T  U  F
H  C  CH  SH  E  U  Y
Rambler's Top100
Privacy policy:
Copyright 2009 - 2017. Universal reference book of medicines. All rights reserved.
When using site materials, an active hyperlink is required!