Universal reference book for medicines
Product name: HONDROTEK FORTE (CHONDROTEK FORTE)

Active substance: chondroitin sulfate sodium, glucosamine, tocopherol

Type: A drug stimulating the process of cartilage tissue regeneration

Manufacturer: NABROS PHARMA (India)
Composition, form of production and packaging
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Hard gelatin capsules, №1, body and cap of white color, contents of capsules - white or white powder with a yellowish hue.
1 tab.

glucosamine sulfate dipotassium salt 500 mg

chondroitin sodium sulfate 250 mg

-tocopherol acetate (VitE) 8 mg

Excipients: Magnesium stearate 2 mg, talc 4 mg, butylhydroxytoluene 1 mg.

The composition of the capsule is gelatinous: titanium dioxide 2.118%, methyl parahydroxybenzoate 0.8%, propyl parahydroxybenzoate 0.2%, water purified from 14 to 15%, gelatin qs to 100%.

10 pieces.
- blisters from PVC / PVDH / aluminum foil (2) - packs cardboard.
10 pieces.
- blisters of PVC / PVDC / aluminum foil (5) - packs of cardboard.
10 pieces.
- blisters from PVC / PVDC / aluminum foil (10) - packs of cardboard.
INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2014.

PHARMACHOLOGIC EFFECT

Chondrotek Forte stimulates the regeneration (restoration) of cartilaginous tissue.
Glucosamine sulfate and chondroitin sulfate, which are part of the drug, participate in the synthesis of connective tissue, helping to prevent cartilage destruction processes and stimulating the regeneration of cartilaginous tissue. The introduction of exogenous glucosamine sulfate enhances the production of a cartilage matrix and provides non-specific cartilage protection against chemical damage. Glucosamine sulfate is involved in the biosynthesis of proteoglycans, hyaluronic, chondroitinsulfuric acids, which are a building material for articular membranes, intraarticular fluid and cartilaginous tissue.
Chondroitin sulfate is involved in the construction of cartilaginous tissue, serves as an additional substrate for the formation of a healthy cartilage matrix.
Stimulates the formation of hyaluronone, the synthesis of proteoglycans and type II collagen. Protects hyaluronone from enzymatic cleavage (by suppressing the activity of hyaluronidase) and the damaging effect of free radicals; maintains the viscosity of the synovial fluid, stimulates mechanisms of cartilage repair and restores the activity of those enzymes that break down cartilage (elastase, hyaluronidase). Chondroitin sulfate helps to restore the elasticity of the joint bag, cartilage surfaces of the joints, plays the role of natural lubrication of the joint surfaces. Reduces the activity of the inflammatory process in the tissues of cartilage and joints. Reduces the need for non-steroidal anti-inflammatory drugs in patients with arthrosis.
Glucosamine sulfate and chondroitin sulfate, when combined, have a greater effect due to synergy, compared to the individual effect of each of these components.

Vitamin E as an antioxidant inhibits the development of free radical reactions, prevents the formation of peroxides that damage the cellular and subcellular cartilage membranes, which is important for the body in osteoarthritis.

PHARMACOKINETICS

Glucosamine sulfate is distributed in tissues: the highest concentrations are found in the liver, kidneys and articular cartilage.
About 30% of the dose is persistently persistent in bone and muscle tissue. It is excreted mainly with urine in unchanged form; in part - with feces. T 1/2 - 68 h.
Chondroitin sulfate is metabolized by desulfurization.
It is excreted in the urine, T 1/2 - 310 min.
Vitamin E is absorbed from the duodenum by 50-80%.
It binds to beta-lipoproteins of blood. Deposited in all organs and tissues, especially in adipose tissue, is excreted in bile (more than 90%).
INDICATIONS

- osteoarthrosis I-III st.
peripheral joints and spine.
DOSING MODE

Inside, adults and teenagers over 15 years , before meals, drinking 1 glass of water, 2 capsules 2 times a day.
The duration of treatment is 7-8 weeks. If necessary, repeat the treatment.
SIDE EFFECT

Rarely, abnormalities of the function of the digestive tract (pain in epigastrium, flatulence, diarrhea or constipation), dizziness, allergic reactions.

CONTRAINDICATIONS

hypersensitivity to the components of the drug;

- pronounced impairment of kidney function;

- Children's age till 5 years;

- Pregnancy, lactation.

With caution: bleeding and a tendency to bleeding, diabetes, bronchial asthma.

PREGNANCY AND LACTATION

Contraindicated in pregnancy and lactation.

APPLICATION FOR FUNCTIONS OF THE LIVER

Contraindicated in marked violation of kidney function.

APPLICATION FOR CHILDREN

Contraindicated for children under 5 years.

SPECIAL INSTRUCTIONS

Impact on the ability to drive vehicles and manage mechanisms

There is no information about the possible effect of the drug on the ability to drive vehicles and mechanisms.

OVERDOSE

Cases of overdose are not known.

DRUG INTERACTION

Compatible with non-steroidal anti-inflammatory drugs, glucocorticosteroids.

Against the background of taking the drug, the need for non-steroidal anti-inflammatory drugs is reduced, the absorption of tetracyclines is increased and penicillin is reduced.

It is possible to increase the effect of anticoagulants, antiplatelet agents, fibrinolytic agents.

TERMS OF RELEASE FROM PHARMACY

Without recipe.

TERMS AND CONDITIONS OF STORAGE

In a dry place at a temperature of no higher than 25 ° C.
Keep out of the reach of children. Shelf life - 3 years.
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