Universal reference book for medicines
Product name: HONDROXIDE ® FORTE (CHONDROXIDE FORTE)

Active substance: chondroitin sulfate sodium, meloxicam

Type: A drug stimulating the process of cartilage tissue regeneration, with anti-inflammatory action

Manufacturer: NIZHFARM (Russia)
Composition, form of production and packaging
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Cream for external use from light yellow with a greenish shade to yellow with a greenish tinge, with the smell of dimethylsulfoxide.
1 g

chondroitin sulfate 50 mg

meloxicam 10 mg

Auxiliary substances: dimethylsulfoxide (dimexide) - 100 mg, propylene glycol 100 mg, macrogol cetostearate (Eumulgin® B2) - 12 mg, cetostearyl alcohol (cetyl alcohol - not more than 60%, stearyl alcohol - not less than 40%) (Lanette O ) - 42 mg, paraffin liquid (Vaseline oil medical) - 100 mg, Vaseline 80 mg, imidourea (Germall ® ) - 3 mg, sodium disulfite (sodium metabisulphite) - 500 μg, purified water - up to 1 g.

10 g - aluminum tubes (1) - packs of cardboard.

20 g - aluminum tubes (1) - packs of cardboard.

25 grams - tubes of aluminum (1) - packs of cardboard.

30 g - aluminum tubes (1) - cardboard packs.

50 g - aluminum tubes (1) - packs of cardboard.

100 g - aluminum tubes (1) - packs of cardboard.

10 g - polyethylene tubes (1) - cardboard packs.

20 g - polyethylene tubes (1) - packs of cardboard.

25 g - polyethylene tubes (1) - cardboard packs.

30 g - polyethylene tubes (1) - cardboard packs.

50 g - polyethylene tubes (1) - cardboard packs.

100 g - polyethylene tubes (1) - packs of cardboard.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2014.

PHARMACHOLOGIC EFFECT

Chondroxide ® Forte cream has a combined effect: it slows the progression of osteoarthritis and osteochondrosis, has analgesic effect, promotes the increase in joint motion (in the area of ​​application of the cream), has anti-inflammatory effect, reduces swelling of the joints.
Due to the optimal combination of the components of the cream, the mutual enhancement of their analgesic and anti-inflammatory effects is noted.
Chondroitin sulfate is a high molecular weight mucopolysaccharide, which is a natural component of cartilaginous tissue.
Chondroitin sulfate improves phosphoric-calcium metabolism in cartilaginous tissue, inhibits enzymes that cause cartilage damage, inhibits degeneration (destruction) of cartilaginous tissue, stimulates the synthesis of glycosaminoglycans, promotes the regeneration (restoration) of cartilaginous surfaces of joints, accelerates the repair of their repair, prevents the collapse of connective tissue . This leads to a decrease in soreness and increased mobility of the affected joints.
Meloksikam - NSAIDs, has an anti-inflammatory, analgesic effect.
Meloxicam selectively inhibits COX-2, disrupts the metabolism of arachidonic acid, reduces the number of prostaglandins (mediators of pain and inflammation) in the inflammation focus. Meloxicam is a chondrojetral drug, does not have a negative effect on cartilaginous tissue, does not affect the synthesis of proteoglycan by chondrocytes of articular cartilage.
PHARMACOKINETICS

Data on pharmacokinetics are not available.

INDICATIONS

The drug is recommended for use in the complex therapy of degenerative-dystrophic diseases of the musculoskeletal system:

- osteoarthrosis, osteochondrosis of the spine;

- other diseases of the joints, accompanied by pain syndrome.

DOSING MODE

Outwardly.
Slightly rub strip of cream length from 1 to 5 cm, the frequency of application - 2-3 times / day. The required amount of the drug depends on the size of the painful area. After applying the product, the hands should be thoroughly washed. The duration of treatment depends on the indications and the effect observed. After 2 weeks of use, consult a physician.
SIDE EFFECT

There may be allergic reactions from the skin (itching, redness, skin rash).

If there are any side effects, stop using the cream and consult a doctor.

CONTRAINDICATIONS

- violation of the integrity of the skin in places of intended application;

- children's age till 12 years;

- hypersensitivity to the components of the drug (as well as to other NSAIDs).

With caution : with a violation of the kidneys and liver, with severe pathology of the gastrointestinal tract (peptic ulcer in the phase of exacerbation), with severe pathology of the blood system, the elderly.

PREGNANCY AND LACTATION

The use of the drug is contraindicated during pregnancy and lactation.

APPLICATION FOR FUNCTIONS OF THE LIVER

Use with caution in case of impaired renal function.

APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS

Use with caution in case of impaired liver function.

APPLICATION FOR CHILDREN

Contraindicated in children under 12 years.

APPLICATION IN ELDERLY PATIENTS

Use with caution in old age.

SPECIAL INSTRUCTIONS

The drug should be applied only to intact skin, avoiding getting on open wounds.
Do not allow the product to get into the eyes and mucous membranes.
You should consult your doctor before sharing the Chondroxide ® Forte Cream with other NSAIDs, and also if you need to use the drug for more than 2 weeks.

Impact on the ability to drive vehicles and manage mechanisms

The drug does not cause sedation, psychomotor disorders and does not affect a patient's ability to engage in potentially dangerous activities that require increased attention and speed of mental and motor reactions.

OVERDOSE

Extremely low systemic absorption of active components of the drug with external application makes an overdose almost impossible.

DRUG INTERACTION

Cases of interaction or incompatibility with other drugs are not described.

TERMS OF RELEASE FROM PHARMACY

The drug is approved for use as a means of OTC.

TERMS AND CONDITIONS OF STORAGE

The drug should be stored out of the reach of children at a temperature of no higher than 20 ° C.
Shelf life - 2 years.
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