Universal reference book for medicines
Product name: HAIMIX ® (HIGHMIX)

Active substance: comb.
drug
Type: Parenteral preparation - amino acid solution

Manufacturer: КРАСФАРМА (Russia)
Composition, form of production and packaging
Solution for infusions is
colorless or slightly yellowish, transparent, with a specific odor.

1 l

L-alanine 6.4 g

L-arginine hydrochloride 6.4 g

L-valine 4.9 g

L-Histidine hydrochloride 3.2 g

glycine 8 g

L-isoleucine 4.4 g

L-leucine 9.8 g

L-lysine hydrochloride 11.5 g

L-Methionine 5.7 g

L-proline 6.4 g

L-threonine 4.3 g

L-tryptophan 1.44 g

L-phenylalanine 7 g

D-sorbitol 50 g

total amino acid content 80 g

total nitrogen 11.4 g / l osmolarity 1000 mOsm / l energy value 506.5 kcal

100 ml - bottles for blood substitutes (1) - packs cardboard.

200 ml - bottles for blood substitutes (1) - packs cardboard.

400 ml - bottles for blood substitutes (1) - packs cardboard.

500 ml - bottles for blood substitutes (1) - packs cardboard.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2008.

PHARMACHOLOGIC EFFECT

The drug for parenteral nutrition.
Balanced mixture of amino acids. Easily absorbed by the body with a slow introduction. The energy needs of the body are provided by the carbohydrate constituting part of Himix, which is an insulin-independent source of energy, which excludes the risk of hyperglycemic acidosis. Included in the drug amino acids are included in the biosynthesis of body proteins and contribute to a positive nitrogen balance, the elimination or weakening of protein deficiency.
PHARMACOKINETICS

Data on the pharmacokinetics of the preparation of Heimix are not available.

INDICATIONS

The preparation is indicated for parenteral protein nutrition with:

- hypoproteinemia of various genesis;

- impossibility or sharp restriction of food intake by usual way in pre- or postoperative period;

- extensive deep burns (especially burns exhaustion);

- injuries;

- fractures;

- Purulent processes, sepsis;

- Functional liver failure;

- inflammatory conditions of the intestine;

- cachexia;

- constant fever states;

poisoning;

- malignant tumors of the gastrointestinal tract;

- in children older than 2 years with protein degeneration, hypotrophy, gastrointestinal defects.

Heimics can be used in patients with diabetes mellitus, liver and kidney pathology.

DOSING MODE

The drug is injected / drip.
The initial infusion rate (during the first 30 min) is 10-20 drops / min, then the infusion rate is gradually increased to 25-35 drops / min.Excess of infusion rate is undesirable, because possible loss of the drug with urine. For the introduction of each 100 ml of the solution it takes at least 1 hour.
With partial parenteral nutrition, the Heimix is ​​used at 400-500 ml / day for 5 days or more.

If enteral intake of proteins is completely excluded, then the drug is administered daily at 400-1000 ml / day until the recovery of enteral nutrition.

Heimiks can be combined with the simultaneous infusion of 10-20% glucose solution with insulin (for 4 g glucose 1 unit of insulin), vitamin B 1 - 1 ml 2.5-5% solution, vitamin B 6 - 1 ml 5% solution, vitamin C - 4 -6 ml of 5% solution, anabolic steroids: nerobol - 15 mg / day (5 mg 3-4 times / day sublingually) or retabolyl (nerobolil) - 50 mg IM once a week (for adults);
women in the postoperative period should not use anabolic hormones.
The rate of administration of the glucose solution should be strictly controlled and not exceed 0.5 g (in terms of dry matter) / 1 kg of body weight / h.

SIDE EFFECT

Possible: allergic reactions, infections at the injection site, thrombophlebitis.

CONTRAINDICATIONS

- severe heart failure;

- severe renal failure;

- Children under 2 years.

With caution should be used in patients with heart failure, renal (creatinine clearance more than 30 ml / min) / liver failure, hemorrhagic stroke, thrombophlebitis.

PREGNANCY AND LACTATION

The safety of the use of the drug Heimix during pregnancy and lactation (breastfeeding) is not established.

APPLICATION FOR FUNCTIONS OF THE LIVER

Contraindicated in severe renal failure.

Caution should be applied to the drug in renal (creatinine clearance more than 30 ml / min) insufficiency.

APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS

With caution , use the drug for liver failure.

SPECIAL INSTRUCTIONS

If parenteral nutrition is necessary in patients with cardiac decompensation, cerebral hemorrhage, thrombophlebitis, Hymiks is used with the following conditions: when cardiac decompensation is prescribed, the drug is administered in reduced doses, with cerebral hemorrhages the volume of the injected fluid, including Heimix, should not exceed 2 l / day, with thrombophlebitis Heimix is ​​recommended to enter through the central veins.

Patients with renal and hepatic insufficiency (which use of drugs for parenteral use, as a rule, is contraindicated), transfusion of Heimix in limited doses is permissible, because
it does not contain peptides and humic substances.
OVERDOSE

If the recommended speed of injection of Hymix is ​​exceeded, there may be hyperemia of the face, a sensation of heat, a headache, nausea, vomiting.

Treatment: discontinue the infusion of the drug and prescribe desensitizing therapy.

DRUG INTERACTION

Drug interaction of the drug with other medicines is not described.

TERMS OF RELEASE FROM PHARMACY

The drug is released by prescription.

TERMS AND CONDITIONS OF STORAGE

The drug should be stored in a dark place at a temperature of 10 ° to 25 ° C.
Shelf life - 2 years.
At low temperatures, a solution may precipitate as a result of the crystallization of amino acids.
In such cases, it is necessary to heat the vial with a solution up to 50-60 ° C before dissolving the sediment, after reaching the transparency of the solution, stop heating, allow the solution to cool to body temperature, then it can be injected iv.
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