Universal reference book for medicines
Name of the preparation: CHLOROPIRAMINE (CHLOROPYRAMINE)

Active substance: chloropyramine

Type: The blocker of histamine H 1 -receptors.
Anti-allergic drug
Manufacturer: ФармФірма СОТЕКС (Russia)
Composition, form of production and packaging

The solution for intravenous and / or injection is clear, colorless or slightly yellowish, or slightly greenish, with a characteristic odor.

1 amp.
(1 ml)
chloropyramine hydrochloride * 20 mg

* in terms of 100% of the substance.

Auxiliary substances: water d / u - up to 1 ml.

1 ml - ampoules of colorless glass (5) - packings of cellular contour (1) - packs cardboard.

1 ml - ampoules of colorless glass (5) - packings of cellular contour (2) - packs cardboard.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2011.

PHARMACHOLOGIC EFFECT

Chloropyramine is a blocker of histamine H 1 -receptors.
The chemical structure refers to the derivatives of ethylenediamine. Chloropyramine selectively blocks histamine H 1 -receptors and reduces the permeability of capillaries. Prevents development and facilitates the course of allergic reactions. Has sedative, antihistaminic, m-holinoblokiruyuschee and pronounced antipruritic effect. Has moderate spasmolytic activity and antiemetic effect.
PHARMACOKINETICS

Evenly distributed in the body, including the central nervous system.
Penetrates through the BBB. The association of chloropyramine with plasma proteins is 7.9%. The binding peak was noted at pH 6.8-7.4. Therapeutic concentration persists for 4-6 hours. Intensively metabolized in the liver. It is excreted mainly through the kidneys with urine in the form of metabolites. The excretion of chloropyramine in children can occur faster than in adults.
INDICATIONS

- treatment of symptoms of year-round and seasonal allergic rhinitis and allergic conjunctivitis;

- Pollinosis (hay fever);

- hives;

allergic dermatoses;

- drug allergy;

- allergic reactions to insect bites;

- angioedema;

- serum sickness.

DOSING MODE

In / in or / m.

Adults prescribe 20-40 mg / day (the contents of 1-2 ampoules).

Treatment in children begins with a dose of 5 mg (0.25 ml).
In the future, the dose is increased depending on the age of the child.
Children aged 1-12 months - 5 mg (0.25 ml).

Children aged 1-6 years - 10 mg (0.5 ml).

Children aged 7-18 years - 10-20 mg (0.5-1 ml).

The daily dose should not exceed 2 mg / kg of body weight.

In severe allergy, treatment should begin with the injection form of chloropyramine.
First it is injected / slowly, then goes to the / m introduction and in the final phase of treatment they switch to taking the pills inside. The terms of treatment are set individually depending on the clinical symptoms and the patient's condition.
Elderly, emaciated patients : the use of the drug chloropyramine requires special care, tk.
In these patients, antihistamines often cause side effects (dizziness, drowsiness).
Patients with impaired liver function: a dose reduction may be required due to a decrease in the metabolism of the active component of the drug in liver diseases.

Patients with impaired renal function: it may be necessary to change the regimen of the drug and reduce the dose due to the fact that the active component is mainly released through the kidneys.

SIDE EFFECT

From the side of the central nervous system: lethargy, weakness, drowsiness, dizziness, headache, euphoria, a feeling of fatigue, irritability, tremor, convulsions, impaired coordination of movements, impaired vision;
children may have some stimulating effect on WYC, manifested by anxiety, increased irritability, insomnia.
On the part of the digestive system: dry mouth, nausea, vomiting, gastralgia, diarrhea / constipation, loss or increase in appetite.

From the side of the urethra: difficulty urinating.

From the cardiovascular system: a decrease in blood pressure (usually in elderly patients), tachycardia, arrhythmia.

From the hemopoietic system: very rarely - leukopenia, agranulocytosis.

On the part of the organs of vision: increased intraocular pressure.

Other: photosensitization, muscle weakness.

Allergic reactions to the drug.

CONTRAINDICATIONS

acute attack of bronchial asthma;

- simultaneous use of MAO inhibitors;

- Stomach ulcer in the stage of exacerbation;

- hyperplasia of the prostate;

- severe respiratory failure;

- newborn children (up to 1 month);

- pregnancy

- lactation period;

- individual hypersensitivity to the drug or its components.

With caution, the drug should be prescribed to elderly patients, with liver failure and / or heart disease, stomach ulcers and / or duodenal ulcers, with medications, oppressive central nervous system, urinary retention, angle-closure glaucoma.

PREGNANCY AND LACTATION

Contraindicated in pregnancy and lactation.

APPLICATION FOR FUNCTIONS OF THE LIVER

Patients with impaired renal function: it may be necessary to change the regimen of the drug and reduce the dose due to the fact that the active component is mainly released through the kidneys.

APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS

Patients with impaired liver function: a dose reduction may be required due to a decrease in the metabolism of the active component of the drug in liver diseases.

APPLICATION FOR CHILDREN

Treatment in children begins with a dose of 5 mg (0.25 ml).
In the future, the dose is increased depending on the age of the child.
Children aged 1-12 months - 5 mg (0.25 ml).

Children aged 1-6 years - 10 mg (0.5 ml).

Children aged 7-18 years - 10-20 mg (0.5-1 ml).

The daily dose should not exceed 2 mg / kg of body weight.

Contraindicated:

- newborn children (up to 1 month).

APPLICATION IN ELDERLY PATIENTS

Elderly, emaciated patients : the use of the drug chloropyramine requires special care, tk.
In these patients, antihistamines often cause side effects (dizziness, drowsiness).
SPECIAL INSTRUCTIONS

During treatment, it is unacceptable to drink alcoholic beverages.

Taking the drug at night can increase the symptoms of reflux esophagitis.

If during prolonged use of the drug there is an unreasonable increase in body temperature, laryngitis, pale skin, jaundice, ulceration of the oral mucosa, the appearance of hematomas, unusual and difficult to stop bleeding, it is necessary to consult a doctor, since prolonged therapy with antihistamines may lead to violations hemopoiesis.

Antihistamines can distort the reaction when setting skin allergological tests, therefore, a few days before the planned test, the drug should be discontinued.

When combined with ototoxic drugs, chloropyramine can mask the early manifestations of ototoxicity.

Impact on the ability to drive vehicles and manage mechanisms

Patients who use chloropyramine, it is recommended to refrain from driving vehicles, working with mechanisms, as well as from other activities requiring increased concentration of attention and speed of psychomotor reactions.

OVERDOSE

Symptoms: children - excitement, anxiety, hallucinations, athetosis, ataxia, convulsions, mydriasis, pupil immobility, hyperemia of the facial skin, hyperthermia;
then - a collapse, a coma. In adults, depression (inhibition, depression) or excitation of the central nervous system (psychomotor agitation), very rarely-hallucinations, coordination disorder, dilated pupils and their lack of response to light, dry mouth, hyperthermia and hyperemia of the skin, convulsions, severe cases - a coma.
Treatment: symptomatic therapy (including the appointment of antiepileptic drugs, caffeine, phenamine), resuscitation, artificial ventilation - according to the indications.
There is no specific antidote.
DRUG INTERACTION

Strengthens the effect of drugs for general anesthesia, hypnotics, sedatives, tranquilizers, m-holinoblokatorov, opioid analgesics, local anesthetics.

Tricyclic antidepressants and MAO inhibitors increase m-cholinoblocking and inhibitory effects on the central nervous system.

Caffeine and phenamine reduce the depressant effect on the central nervous system.

Simultaneous use with ethanol is not recommended (risk of severe CNS depression).

TERMS OF RELEASE FROM PHARMACY

The drug is released by prescription.

TERMS AND CONDITIONS OF STORAGE

Keep the drug in a dark place at a temperature of no higher than 25 ° C.
Keep out of the reach of children.
Shelf life - 4 years.

Do not use after the expiration date printed on the package.

Alphabetical index of medicines:
A  B  V  G  D  E  J
Z  I  Y  K  L  M  N
O  P  R  S  T  U  F
H  C  CH  SH  E  U  Y
Rambler's Top100
Privacy policy:
Copyright 2009 - 2017. Universal reference book of medicines. All rights reserved.
When using site materials, an active hyperlink is required!