Universal reference book for medicines
Product name: HEPABOS (HEPABOS)

Active substance: comb.
drug
Type: Hepatoprotector

Manufacturer: BOSNALIJEK (Bosnia and Herzegovina)
Composition, form of production and packaging
Capsules
hard, gelatinous, opaque, №1.
The capsule case is red, the lid is brown. The contents of the capsule are a paste-like mass of yellow color.
1 caps.

"Essential" phospholipids 300 mg

nicotinamide 30 mg

pyridoxine hydrochloride 6 mg

riboflavin 6 mg

thiamine mononitrate 6 mg

? -tocopherol acetate 6 mg

Excipients: medium-chain triglycerides 45 mg.

10 pieces.
- blisters Al / PVC (3) - packs cardboard.
10 pieces.
- Al / PVC blisters (5) - cardboard packs.
10 pieces.
- blisters Al / PVC (10) - packs of cardboard.
INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2013.

PHARMACHOLOGIC EFFECT

Essential phospholipids included in the preparation are the main structural elements of external cell membranes and organelles of hepatocytes.
In the body they have a normalizing effect on the metabolism of lipids, proteins and the detoxification function of the liver; restore and preserve the cellular structure of the liver, regulate the activity of certain enzymatic systems, slow the process of formation of connective tissue in the liver.
The vitamins that make up the drug function as coenzymes in various biochemical processes and potentiate the action of essential phospholipids.

PHARMACOKINETICS

Essential phospholipids are well absorbed in the gastrointestinal tract, incl.
in the form of biologically active products of their hydrolysis by digestive enzymes, which are transported through the intestinal wall into the lymphatic channel. In the liver, a partial resynthesis of phosphatidylcholine from the products of hydrolysis occurs.Essential phospholipids are excreted from the body mainly during defecation, a small part with urine. Vitamins, which are part of the drug, are excreted by the kidneys. Alpha-tocopherol acetate is excreted with bile, partly with kidneys. The half-life of the drug is about 20 hours.
INDICATIONS

- fatty degeneration of the liver of various etiologies;

- violations of lipid metabolism of the liver;

- Hepatitis and cirrhosis of the liver;

- toxic damage to the liver (including alcohol, narcotic, drug etiology);

- radiation sickness;

- psoriasis (as part of complex therapy).

DOSING MODE

Inside, 2-3 capsules 3 times a day, with food, swallowing whole with enough water.

The course of treatment - at least 3 months, if necessary, prolongation of treatment.

SIDE EFFECT

Usually the drug is well tolerated.
Very rarely observed allergic reactions, gas formation, heartburn, nausea, diarrhea, staining the urine in a dark yellow color (due to the content of B vitamins).
CONTRAINDICATIONS

- hypersensitivity to the components of the drug;

- cholestasis;

- Empyema of the gallbladder;

- Children's age till 16 years.

PREGNANCY AND LACTATION

The use of the drug during pregnancy is possible only on the recommendation of a doctor if the expected benefit for the mother exceeds the potential risk to the fetus.

If you need to take the drug during lactation, it is recommended that you decide whether to stop breastfeeding.

APPLICATION FOR CHILDREN

Contraindicated for children under 16 years.

DRUG INTERACTION

Levodopa - a decrease in the effect of levodopa due to the pyridoxine contained in the preparation.

Kolestyramin - decreases the absorption of nicotinamide contained in the drug.

It is recommended to observe the interval for 4-6 hours between the two preparations.

TERMS OF RELEASE FROM PHARMACY

On prescription.

TERMS AND CONDITIONS OF STORAGE

In a dry place at a temperature of no higher than 25 ° C.
Keep out of the reach of children. Shelf life - 2 years.
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