Universal reference book for medicines
Product name: FERRETAB ® Comp. (FERRETAB COMP.)

Active substance: ferrous fumarate, folic acid

Type: Anti-anemic drug

Manufacturer: LANNACHER HEILMITTEL (Austria) manufactured by GLPHARMA (Austria)
Composition, form of production and packaging
Capsules of prolonged action
hard gelatinous, the size 2, the case and a cover of red color;
contents of capsules - 3 round flat mini-tablets of reddish-brown color (iron fumarate) and 1 round flat minitablet of yellow color (folic acid); the presence of inclusions is allowed on the tablets.
1 caps.

iron fumarate 163.56 mg,

equivalent to 152.1 mg of dry matter, equivalent to 50 mg of iron

Folic acid (Vit B c ) 540 μg,

is equivalent to 500 μg of dry matter

Excipients: minitablets of iron fumarate: lactose monohydrate - 3.42 mg, silicon colloidal dioxide - 600 μg, magnesium stearate - 600 μg, methyl methacrylate and ethyl acrylate copolymer (2: 1) - 4.66 mg;
minitabletka folic acid: lactose monohydrate - 24.21 mg, cellulose microcrystalline - 24.25 mg, silicon dioxide colloid - 500 mcg, magnesium stearate - 500 mcg.
The composition of the capsule body: gelatin - 36.4804 mg, azorubin dye - 74.2 μg, quinoline yellow dye - 148.4 μg, titanium dioxide - 496 μg.

The capsule capsule composition: gelatin - 24.3203 mg, azorubin dye - 49.8 μg, dye quinoline yellow - 99.6 μg, titanium dioxide - 330.3 μg.

10 pieces.
- blisters (3) - packs of cardboard.
INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2014.

PHARMACHOLOGIC EFFECT

Combined anti-anemic drug, the effect of which is due to the properties of the components that make up its composition.

Iron fumarate is the salt of iron, a microelement necessary for the synthesis of hemoglobin.
When iron is used in the form of salts, its deficiency in the body is rapidly replenished, which leads to a gradual regression of clinical (weakness, fatigue, dizziness, tachycardia, tenderness and dry skin) and laboratory symptoms of anemia.
Folic acid is necessary for the normal maturation of megaloblasts and the formation of normoblasts.
Stimulates erythropoiesis, participates in the synthesis of amino acids, nucleic acids, purines and pyrimidines, in the exchange of choline. When pregnancy protects the body from the effects of teratogenic factors.
Ferretab ® Comp.
helps maintain and restore normal levels of iron in the blood. Prevents anemia (including pregnancy), miscarriage, premature birth and mental development of the child, which can be observed with a deficiency of iron and folic acid in the body. The amount of assimilated iron varies between 5% and 35%.
In the serum, iron binds to transferrin and is involved in the formation of hemoglobin, myoglobin, cytochrome oxidase, catalase and peroxidase or is deposited in body tissues in the form of ferritin.

PHARMACOKINETICS

Suction and distribution

Folic acid is absorbed mainly from the upper parts of the digestive tract (duodenum);
the binding to plasma proteins is 64%.
Metabolism and excretion

Excretion of iron occurs with feces, urine and sweat.

Folic acid is metabolized in the liver and is secreted mainly by the kidneys, and also partially with feces.

INDICATIONS

Treatment and prevention of iron deficiency:

- during pregnancy;

- due to a violation of absorption of iron from the digestive tract;

- due to prolonged bleeding;

- due to unbalanced and malnutrition.

DOSING MODE

The drug is prescribed 1 cap. / Day.

If the iron or folic acid deficiency is expressed, the dose is increased to 2-3 caps / day.
Supportive therapy should be continued for at least 4 weeks after reaching a normal level of hemoglobin for the normalization of serum ferritin, reflecting iron stores in the body.
The drug should be taken on an empty stomach, washed down with a large amount of liquid.

SIDE EFFECT

On the part of the digestive system: in some cases - a feeling of overflow of the stomach, discomfort, nausea, vomiting.

Other: allergic reactions.

The drug is usually well tolerated.

CONTRAINDICATIONS

- diseases accompanied by the accumulation of iron in the body (aplastic and hemolytic anemia, thalassemia, hemosiderosis, hemochromatosis);

- Impaired iron absorption (sidero-achestic anemia, lead anemia, pernicious anemia / vitamin B deficiency 12 );

- Anemia, not associated with deficiency of iron or folic acid;

- Hypersensitivity to the components of the drug.

PREGNANCY AND LACTATION

It is possible to use Ferretab ® Comp.
at pregnancy and in a lactemia (thoracal feeding) under indications.
SPECIAL INSTRUCTIONS

Before starting therapy with the drug, it is necessary to determine the iron and serum ferritin content (ie document iron deficiency).

Therapy with Ferretab ® Comp.
should be performed prior to the normalization of the blood picture (8-12 weeks).
When applying the drug, a darker staining of the stool is possible.

Against the background of the drug it is possible to obtain a false positive result of a benzidine test.

OVERDOSE

Symptoms: There may be an increase in the manifestations of the described side effects.

Treatment: first of all, it is necessary to determine the content of iron and ferritin in the blood serum.
With a significant excess of normal values ​​of ferritin content in the serum, deferoxamine is prescribed in accordance with the manufacturer's recommended dose.
DRUG INTERACTION

With the simultaneous use of the drug Ferretab ® comp.
with antacids, iron absorption deteriorates.
Simultaneous reception with ascorbic acid helps to improve the absorption of iron.

With the simultaneous use of the drug Ferretab ® comp.
with ascorbic acid, iron absorption improves.
When combined use of antibiotics group of tetracyclines and the drug Ferretab ® comp.
Absorption of iron is disrupted (this combination should be avoided).
Kolestyramine, phenytoin, phenobarbital, carbamazepine, sulfasalazine, hormonal contraceptives, folic acid antagonists, trimethoprim, triamterene, solid food, bread, raw cereals, dairy products, eggs, tea reduce iron absorption.

TERMS OF RELEASE FROM PHARMACY

The drug is released by prescription.

TERMS AND CONDITIONS OF STORAGE

The drug should be stored out of the reach of children, protected from light at a temperature of no higher than 25 ° C.
Shelf life - 3 years.
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