Composition, form of production and packaging
The solution for oral administration is transparent, brown, with a pleasant characteristic odor.
1 f. (15 ml)
iron protein succinylate 800 mg,
which corresponds to the content of Fe 3+ 40 mg
Excipients: sorbitol, propylene glycol, sodium methyl parahydroxybenzoate, sodium propyl parahydroxybenzoate, cherry flavor, sodium saccharin, purified water.
15 ml - polyethylene bottles (10) - packs of cardboard.
INSTRUCTION FOR THE SPECIALIST.
Description of the drug approved by the manufacturer for the printed edition of 2008.
PHARMACHOLOGIC EFFECT
Anti-anemic drug. Ferlatum contains iron protein succinylate, which is a complex compound, where the trivalent iron atoms are surrounded by a semisynthetic protein carrier, which prevents damage to the gastric mucosa.
The main function of iron is the transfer of oxygen to the tissues. Iron is a part of hemoglobin, myoglobin, iron-containing cytochrome enzymes, carries electrons and acts as a catalyst for oxidation, hydroxylation and other metabolic processes.
PHARMACOKINETICS
In the acidic environment of the stomach, the proteins precipitate and form around the iron ions a dense protein shell, which excludes the irritating effect of iron on the gastric mucosa.
In the alkaline environment of the duodenum, the protective protein membrane dissolves and iron is released at the site of its best absorption.
In the blood, iron comes through active transport (absorption), which explains the impossibility of an overdose.
INDICATIONS
- treatment of latent and clinically pronounced iron deficiency (iron deficiency anemia);
- Prevention of iron deficiency during pregnancy, lactation, active growth, with prolonged bleeding, against a background of inadequate and unbalanced nutrition.
DOSING MODE
Ferlatum should be taken orally, before or after a meal.
Adults prescribe at 15-30 ml / day (in an amount equivalent to 40-80 mg of Fe 3+ ) in 2 divided doses.
For children, starting from the newborn period, the drug is prescribed at 1.5 ml / kg body weight / day (in an amount equivalent to 4 mg / kg / day Fe 3+ ) in 2 divided doses.
Multiplicity of drug intake can be established by the doctor individually.
To prevent iron deficiency during pregnancy, the drug is prescribed 15 ml / day; for the treatment of latent or clinically pronounced iron deficiency - 15-30 ml / day in 2 divided doses.
After the normalization of serum iron and hemoglobin, therapy is continued for another 8-12 weeks, appointing Ferlatum in a maintenance dose.
SIDE EFFECT
On the part of the digestive system: diarrhea, constipation, nausea, epigastric pains (which disappear when the dose is lowered or the drug is withdrawn) are possible (more often when the drug is used in higher doses).
The patient should be informed that if a side effect occurs, consult a doctor.
CONTRAINDICATIONS
- hemochromatosis;
- violations of iron utilization (lead anemia, sideroahrestic anemia);
- non-iron deficiency anemia (hemolytic anemia or megaloblastic anemia caused by vitamin B12 deficiency);
- chronic pancreatitis;
- cirrhosis of the liver;
- Hypersensitivity to the components of the drug.
PREGNANCY AND LACTATION
Ferlatum is indicated for the prevention and treatment of iron deficiency conditions developing during pregnancy and lactation (breastfeeding).
APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS
Contraindicated use of the drug for cirrhosis.
APPLICATION FOR CHILDREN
For children, starting from the newborn period, the drug is prescribed at 1.5 ml / kg body weight / day (in an amount equivalent to 4 mg / kg / day Fe 3+ ) in 2 divided doses.
SPECIAL INSTRUCTIONS
It should be noted that the total duration of Ferlatum should not exceed 6 months, except for cases associated with chronic blood loss (menorrhagia, hemorrhoids), and pregnancy.
OVERDOSE
Symptoms: To date, no signs of intoxication and excess iron intake into the body have been described; in the first 6-8 hours after the use of iron preparations in excessive doses, the appearance of epigastric pains, nausea, vomiting (sometimes with an admixture of blood), diarrhea, in some cases accompanied by drowsiness, pallor of the skin. Perhaps the development of a shock state up to coma.
Treatment: gastric lavage; if necessary, conduct symptomatic therapy.
DRUG INTERACTION
At simultaneous application of Ferlatum with blockers of histamine H 2 receptors, pharmacological interaction is absent.
Chloramphenicol causes a delayed response to iron therapy.
Pharmacokinetic interaction
At simultaneous application iron preparations break processes of absorption of tetracyclines from GASTROINTESTINAL TRACT (it is necessary to avoid appointment of the given combination).
The absorption of iron increases with the simultaneous administration of ascorbic acid in a dose of more than 200 mg.
Absorption of iron decreases with the simultaneous administration of antacids.
TERMS OF RELEASE FROM PHARMACY
The drug is released by prescription.
TERMS AND CONDITIONS OF STORAGE
The drug should be stored out of the reach of children at a temperature of no higher than 25 В° C. Shelf life - 2 years.
