Universal reference book for medicines
Product name: FENTANYL

Active substance: fentanyl

Type: Actually an opioid receptor agonist.
Analgesic
Manufacturer: GosMPS (Russia)
Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..

PHARMACHOLOGIC EFFECT
Opioid analgesic.
The opioid receptor agonist interacts predominantly with β-receptors. The analgesic effect is significantly superior to morphine. Has a depressing effect on the respiratory center, slows the heart rate, has little effect on blood pressure. Analgesic effect with intravenous administration develops in 1-3 min, and with v / m - after 10-15 min; duration of action for a single injection of not more than 30 minutes.
PHARMACOKINETICS
Metabolism of fentanyl occurs predominantly in the liver.

About 75% is excreted in urine mainly in the form of metabolites, less than 10% - in unchanged form.
About 9% is excreted with feces mainly in the form of metabolites.
INDICATIONS
Neuroleptanalgesia (in combination with droperidol).
Premedication (as part of certain schemes). As an anesthetic: for short-term extracorporeal operations; as an additional tool for operations under local anesthesia; with severe pain with myocardial infarction, lung infarction, renal and hepatic colic; with postoperative pain.
For dermal application: chronic pain with cancer;
unrestrained pain; severe chronic pain in children older than 2 years who took opioid analgesics.
DOSING MODE
Depending on the clinical situation, I / m or IV is used at doses of 2.5-150 μg / kg.
The intervals between each introduction are determined individually.
When the skin is applied, the dose is set depending on the patient's condition and the effectiveness of the treatment.

SIDE EFFECT
From the central nervous system and peripheral nervous system: drowsiness, confusion, hallucinations, euphoria, rigidity of muscles are possible.

From the cardiovascular system: a bradycardia is possible.

On the part of the digestive system: nausea, vomiting, constipation are possible.

From the respiratory system: possible bronchospasm, respiratory depression.

From the urinary system: urinary retention is possible.

Local reactions: with skin application, skin rashes, erythema, pruritus are possible.

CONTRAINDICATIONS
Bronchial asthma, drug addiction, conditions accompanied by depression of the respiratory center, obstetric operations, hypersensitivity to fentanyl.

PREGNANCY AND LACTATION
Use in pregnancy is possible only if the intended benefit to the mother exceeds the potential risk to the fetus.

Fentanyl is excreted in breast milk, so if you need to use during lactation, you should decide whether to stop breastfeeding.

During the use of fentanyl in women of childbearing age, reliable means of contraception should be used.

SPECIAL INSTRUCTIONS
The use of fentanyl is recommended in the presence of an anesthesiologist and under conditions of intensive care.

With IV injection in a dose of 100-500 mcg, acute respiratory depression is possible, up to apnea.

With simultaneous use with insulin preparations, correction of the dosing regimen of fentanyl is required.

DRUG INTERACTION
With simultaneous use with other drugs that exert a depressing effect on the central nervous system, there may be a mutual enhancement of effects.

With the systematic administration of barbiturates, especially phenobarbital, there is a likelihood of reducing the analgesic effect of opioid analgesics.
Long-term use of barbiturates or opioid analgesics stimulates the development of cross tolerance.
Nitrous oxide enhances the muscle rigidity caused by fentanyl.

Naloxone activates breathing, eliminating analgesia after the use of opioid analgesics.

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