Universal reference book for medicines
Product name: FENCAROL (PHENCAROL)

Active substance: quifenadine

Type: The blocker of histamine H 1 -receptors.
Anti-allergic drug
Manufacturer: OLAINFARM (Latvia)

Composition, form of production and packaging

Solution for the / m introduction is transparent, colorless.

1 ml

hifenadine (phencarol base) 10 mg

Excipients: glutamic acid - 6.26 mg, water d / u - up to 1 ml.

1 ml - ampoules (10) - packings contour mesh (1) - packs cardboard.

2 ml - ampoules (10) - packings contour mesh (1) - packs cardboard.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2017.

PHARMACHOLOGIC EFFECT

The blocker of histamine H 1 -receptors.
Prevents development and facilitates the course of allergic reactions. Has antiallergic, antiexudative and antipruritic action, preventing the development of allergic inflammation in the tissue. Weaken the effect of histamine, reduce its effect on vascular permeability (reducing permeability, has anti-edematous effect), reduces its bronchospastic effect and spasmogenic effect on the smooth muscles of the intestine, weakens the hypotensive effect of histamine. Hifenadine reduces histamine content in tissues, which is related to the ability to activate diaminoxidase, an enzyme that inactivates histamine. At course treatment, the antihistamine effect of hifenadine does not decrease. Has a moderate antiserotonin effect, shows a weak m-cholinoblocking activity. Does not exert a depressing effect on the central nervous system.
PHARMACOKINETICS

Suction and distribution

After the / m introduction, the solution is rapidly absorbed, C max of hifenadine in the blood plasma is reached after 30 min.

Hifenadine has low lipophilicity, poorly penetrates the BBB.
The highest content of active substance was observed in the liver, slightly less in the lungs and kidneys, the lowest in the brain (less than 0.05%, which explains the absence of pronounced sedative and hypnotic effect).
Metabolism and excretion

The drug is metabolized in the liver, forming inactive metabolites, which are excreted mainly by the kidneys.

INDICATIONS

In case of severe course and the need for / m use of antihistamines:

- Pollinosis;

- hives;

- angioedema (edema of Quincke).

DOSING MODE

The drug is used in / m.
Because of the irritant effect, the drug should not be given SC.
Pollinosis

2 ml (20 mg) 2 times / day for 3 days, then 2 ml (20 mg) 1 time / day for 2 days.
The total duration of treatment is 5 days. The maximum single dose is 20 mg; the maximum daily dose is 40 mg.
Urticaria and angioedema (edema of Quincke)

2 ml (20 mg) 2 times / day for 5 days, then 2 ml (20 mg) 1 time / day for 3 days.
The total duration of treatment is 8 days. The maximum single dose is 20 mg; the maximum daily dose is 40 mg.
After relief of acute allergic reactions it is recommended to switch to the use of Fenkarol in the form of tablets.

SIDE EFFECT

The drug is well tolerated.

Perhaps: rarely - dry mouth, nausea, vomiting, drowsiness, allergic reactions, headache.

CONTRAINDICATIONS

- children and adolescence under 18;

- Pregnancy;

- the period of lactation (breastfeeding);

- Individual intolerance to hifenadine;

- Hypersensitivity to any of the components of the drug.

With caution should apply the drug with decompensated diseases of the cardiovascular system, GIT, liver and kidneys.

PREGNANCY AND LACTATION

It is not recommended to use the drug during pregnancy.

If it is necessary to treat the drug, breastfeeding should be discontinued.

APPLICATION FOR FUNCTIONS OF THE LIVER

With caution should apply the drug in decompensated diseases of the kidneys.

APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS

With caution should be used in decompensated liver disease.

APPLICATION FOR CHILDREN

Contraindicated use of the drug in children and adolescents under 18 years.

SPECIAL INSTRUCTIONS

The absence of an expressed holinoblokiruyuschey effect allows you to prescribe the drug to patients who are contraindicated antihistamines that have anticholinergic activity.

Impact on the ability to drive vehicles and manage mechanisms

Persons whose profession requires an increased concentration of attention and speed of psychomotor reactions should be determined in advance (by short-term appointment), whether the drug does not have a sedative effect.

OVERDOSE

Symptoms: dry mucous membranes, headache, vomiting, abdominal pain and other dyspepsia.

Treatment: symptomatic therapy.
The patient should take activated charcoal, immediately consult a doctor.
DRUG INTERACTION

Does not increase the oppressive effect of ethanol and hypnotic drugs on the central nervous system.

Possessing weak m-holinoblokiruyuschimi properties, can reduce the motility of the gastrointestinal tract and increase the absorption of slowly absorbed drugs (for example, anticoagulants of indirect action - coumarin derivatives).

TERMS OF RELEASE FROM PHARMACY

The drug is released by prescription.

TERMS AND CONDITIONS OF STORAGE

The drug should be stored out of reach of children, protected from light at a temperature of no higher than 25 ° C.
Shelf life - 2 years.
Alphabetical index of medicines:
A  B  V  G  D  E  J
Z  I  Y  K  L  M  N
O  P  R  S  T  U  F
H  C  CH  SH  E  U  Y
Rambler's Top100
Privacy policy:
Copyright 2009 - 2017. Universal reference book of medicines. All rights reserved.
When using site materials, an active hyperlink is required!