Universal reference book for medicines
Product name: FENCAROL (PHENCAROL)

Active substance: quifenadine

Type: The blocker of histamine H 1 -receptors.
Anti-allergic drug
Manufacturer: OLAINFARM (Latvia)
Composition, form of production and packaging

? Tablets are white or almost white in color, round, flat-cylindrical, with a bevel.
1 tab.
hifenadine hydrochloride 10 mg
Auxiliary substances: potato starch - 14.5 mg, sucrose - 25 mg, calcium stearate - 0.5 mg.
10 pieces. - packings cellular planimetric (2) - packs cardboard.
? Tablets are white or almost white in color, round, flat-cylindrical, with a bevel.
1 tab.
hifenadine hydrochloride 25 mg
Auxiliary substances: potato starch - 40.5 mg, sucrose - 33.5 mg, calcium stearate - 1 mg.
10 pieces. - packings cellular planimetric (2) - packs cardboard.
? Tablets are white or almost white in color, round, flat-cylindrical, with a bevel.
1 tab.
hifenadine hydrochloride 50 mg
Auxiliary substances: potato starch - 74 mg, sucrose - 55 mg, corn modified corn starch - 20 mg, calcium stearate - 1 mg.
15 pcs. - packings of cellular contour (1) - packs cardboard.
15 pcs. - packings cellular planimetric (2) - packs cardboard.
INSTRUCTION FOR THE SPECIALIST.
Description of the drug approved by the manufacturer for the printed edition of 2017.
PHARMACHOLOGIC EFFECT
The blocker of histamine H 1 -receptors. Prevents development and facilitates the course of allergic reactions. Has antiallergic, antiexudative and antipruritic action, preventing the development of allergic inflammation in the tissue. Weaken the effect of histamine, reduce its effect on vascular permeability (reducing permeability, has anti-edematous effect), reduces its bronchospastic effect and spasmogenic effect on the smooth muscles of the intestine, weakens the hypotensive effect of histamine. Hifenadine reduces histamine content in tissues (due to the ability to activate diaminoxidase - an enzyme that inactivates histamine). At course treatment, the antihistamine effect of hifenadine does not decrease. Has a moderate antiserotonin effect, shows a weak m-cholinoblocking activity. Does not exert a depressing effect on the central nervous system.
PHARMACOKINETICS
Suction and distribution
Hifenadine is rapidly absorbed from the digestive tract, absorption is 45%, and after 30 minutes it is found in the tissues of the body. C max in blood plasma is achieved after 1 h. It has low lipophilicity, poorly penetrates through the BBB. The highest concentration of active substance was found in the liver, slightly less in the lungs and kidneys, the lowest in the brain (less than 0.05%, which explains the lack of a pronounced sedative and hypnotic effect).
Metabolism and excretion
Hyphenadine is metabolized in the liver.
Metabolites are excreted by the kidneys and intestines. An unabsorbed part of the drug is excreted through the intestine.
INDICATIONS
- Pollinosis;
acute and chronic urticaria;
- angioedema;
- Allergic rhinitis;
- dermatoses (including eczema, psoriasis, atopic dermatitis);
- Neurodermatitis;
- itchy skin.
DOSING MODE
The drug is taken orally after a meal.
The dosage regimen of the preparation coincides with all indications for use. The dosing of hifenadine may be affected by the severity of the allergic reaction, the individual sensitivity of the patient, as well as the severity of possible side effects.
Adults appoint 50 mg 1-4 times / day or 25 mg 2-4 times / day. The maximum daily dose is 200 mg. The average course of treatment is 10-20 days. If necessary, repeat the treatment.
Children aged 3 to 7 years - 10 mg 2 times / day; at the age of 7 to 12 years - 10-15 mg 2-3 times / day; over 12 years - 25 mg 2-3 times / day. The course of treatment is 10-15 days.
SIDE EFFECT
From the digestive system: dryness of the oral mucosa, nausea, vomiting.
From the side of the central nervous system: drowsiness, headache.
Other: allergic reactions.
CONTRAINDICATIONS
- Pregnancy;
- the period of lactation (breastfeeding);
- Children's age under 3 years (for tablets 10 mg and 25 mg);
- Children and adolescence under 18 years (for tablets 50 mg);
- deficiency of sugar / isomaltase, intolerance to fructose, glucose-galactose malabsorption, t. the preparation contains sucrose;
- Hypersensitivity to the components of the drug.
With caution should prescribe the drug for diseases of the gastrointestinal tract, liver and kidneys.
PREGNANCY AND LACTATION
The use of the drug during pregnancy is contraindicated.
If it is necessary to treat the drug, breastfeeding should be discontinued.
APPLICATION FOR FUNCTIONS OF THE LIVER
With caution should prescribe the drug for kidney disease.
APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS
With caution should prescribe the drug for liver disease.
APPLICATION FOR CHILDREN
The use of the drug in the form of tablets 10 mg and 25 mg is contraindicated in childhood to 3 years , in the form of tablets 50 mg - in children and adolescents under 18 years .
SPECIAL INSTRUCTIONS
Absence of expressed m-holinoblokiruyuschey effect allows you to prescribe the drug to patients who are contraindicated antihistamines that have m-cholinoblocking activity.
Use in Pediatrics
Children are recommended to prescribe Fenkarol in the form of tablets of 10 mg or 25 mg.
Impact on the ability to drive vehicles and manage mechanisms
Fenkarol is approved for use by individuals whose work requires increased concentration of attention and rapid psychomotor reaction (vehicle management and work with mechanisms), however, it is recommended to determine in advance (by short-term appointment) whether the drug has a sedative effect.
OVERDOSE
Symptoms: dry mucous membranes, headache, vomiting, abdominal pain and other symptoms of dyspepsia.
Treatment: gastric lavage, reception of activated charcoal, symptomatic therapy.
In case of an overdose, the patient should consult a doctor.
DRUG INTERACTION
Hyphenadine does not enhance the inhibitory effect of ethanol and hypnotics on the central nervous system.
Possessing weak m-holinoblokiruyuschimi properties, the drug can reduce the motility of the gastrointestinal tract, which increases the absorption of slowly absorbed drugs (for example, anticoagulants indirect effects - coumarins).
TERMS OF RELEASE FROM PHARMACY
The drug is approved for use as a means of OTC.
TERMS AND CONDITIONS OF STORAGE
The drug should be stored out of reach of children, dry, protected from light at a temperature of no higher than 25 ° C. Shelf life: 4 years - for tablets 50 mg and 5 years - for tablets 10 mg and 25 mg.
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