Universal reference book for medicines
Product name: FEBROFID ® (FEBROFID)

Active substance: ketoprofen

Type: NSAID for external use

Manufacturer: MEDANA PHARMA (Poland)
Composition, form of production and packaging
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Gel for external use 2.5% from colorless to light yellowish, transparent or slightly opalescent.
100 g

ketoprofen lysine salt 2.5 g,

which corresponds to the content of ketoprofen 1.6 g

Excipients: macrogol 200-5 g, methyl parahydroxybenzoate 0.15 g, propyl parahydroxybenzoate 0.05 g, carbomer 1.5 g, trolamine 2.5 g, purified water up to 100 g.

30 g - aluminum tubes (1) - cardboard packs.

50 g - aluminum tubes (1) - packs of cardboard.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2010.

PHARMACHOLOGIC EFFECT

NSAIDs for external use.
Has anti-inflammatory, antiexudative and analgesic effect.
Applied with lesions of joints, tendons, ligaments, muscles, skin, veins, lymphatic vessels and lymph nodes.
With articular syndrome leads to a weakening of pain in the joints at rest and during movement, reduces the morning stiffness and swelling of the joints.
PHARMACOKINETICS

Ketoprofen penetrates well through the skin, which provides a local analgesic and anti-inflammatory effect.
Bioavailability of the gel is about 5%. Binding to blood plasma proteins - 99%. Do not cum in the body.
Metabolised in the liver.
About 80% of the dose is excreted in the urine in the form of metabolites, less than 10% is released unchanged.
INDICATIONS

As a drug for external use with symptomatic treatment:

- Pain in the spine;

- neuralgia;

- myalgia;

- inflammatory-degenerative diseases of the musculoskeletal system (including arthritis, bursitis, synovitis, tendinitis, lumbago);

- uncomplicated injuries (including sports, dislocations, sprains or ruptures of ligaments and tendons, bruises, posttraumatic pains);

- as a part of combined therapy for inflammatory diseases of veins (phlebitis, periphlebitis), lymphatic vessels, lymph nodes (lymphangitis, superficial lymphadenitis).

DOSING MODE

The drug is intended for external use.

A small amount (a strip 3-5 cm long) of the gel 2-3 times / day, apply to the corresponding area of ​​the skin and gently rub.

It is not necessary to use dry bandages, tk.
the gel is well absorbed through the skin, has no odor, contains no coloring agents, leaves no greasy stains, does not stain clothes.
SIDE EFFECT

Possible: allergic reactions, skin hyperemia, photosensitivity, skin exanthema, purpura.

CONTRAINDICATIONS

- wet dermatoses, eczema;

- infected abrasions, wounds, burns;

- III trimester of pregnancy;

- the period of lactation (breastfeeding);

- hypersensitivity to ketoprofen and / or other components of the drug;

- hypersensitivity to other NSAIDs (ketoprofen can cause bronchospasm in persons sensitive to acetylsalicylic acid and other NSAIDs).

PREGNANCY AND LACTATION

In the I and II trimesters of pregnancy, the drug can be used only if necessary.
In the third trimester of pregnancy, the use of the drug is contraindicated.
It is not recommended to use the drug during breastfeeding.

APPLICATION FOR FUNCTIONS OF THE LIVER

Care should be taken with prolonged use in patients with severe renal failure.

APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS

Care should be taken with long-term use in patients with severe failure of the liver function.

SPECIAL INSTRUCTIONS

Do not allow the gel to get into the mucous membranes and eyes.

The drug should not be applied to damaged areas of the skin.

Care should be taken with prolonged use in patients with severe hepatic or renal insufficiency.

In case of the appearance of a rash, it is necessary to stop the use of the drug and conduct appropriate therapy.

OVERDOSE

Due to low systemic absorption, an overdose of the drug Febrofid is unlikely.

DRUG INTERACTION

With frequent and prolonged use, symptoms of interaction with other drugs may appear (same as in systemic use).

When co-administered with other NSAIDs, GCS, ethanol, corticotropin, ulceration and the development of gastrointestinal bleeding may occur.

Simultaneous use with oral anticoagulants, heparin, thrombolytic agents, antiaggregants, cefoperazone, cefamandol increases the risk of bleeding.

Ketoprofen reduces the effect of antihypertensive drugs and diuretics (inhibition of prostaglandin synthesis).

Increases the hypoglycemic effect of insulin and oral hypoglycemic drugs (dose adjustment is necessary).
Co-administration with sodium valproate causes disruption of platelet aggregation. Increases the concentration of verapamil and nifedipine in blood plasma.
TERMS OF RELEASE FROM PHARMACY

The drug is approved for use as a means of OTC.

TERMS AND CONDITIONS OF STORAGE

List B. The drug should be stored in a place protected from light and inaccessible to children at a temperature of 15 ° to 25 ° C.
Shelf life - 2 years.
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