Universal reference book for medicines
Product name: UTROZHESTAN ® (UTROGESTAN ® )

Active substance: progesterone

Type: Gestagen

Manufacturer: BESINS HEALTHCARE (Belgium) manufactured by CAPSUGEL PLOERMEL (France) packed with BESINS MANUFACTURING BELGIUM (Belgium)
Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..

PHARMACHOLOGIC EFFECT
Gestagen.
The hormone of the yellow body. Causes the transition of the uterine mucosa from the phase of proliferation caused by the follicular hormone to the secretory phase, and after fertilization promotes its transition into a state necessary for the development of a fertilized egg. Reduces excitability and contractility of the muscles of the uterus and fallopian tubes, stimulates the development of the end elements of the breast. Does not have androgenic activity. Progesterone has a weak effect on protein metabolism, promotes the deposition of fats and the accumulation of glucose in the liver, and also reduces the reabsorption of sodium in the renal tubules.
Progesterone has a blocking effect on the secretion of hypothalamic factors releasing LH and FSH, inhibits the formation of pituitary gonadotropic hormones and inhibits ovulation.

PHARMACOKINETICS
After a / m injection is absorbed quickly and almost completely.
Metabolized in the liver, most metabolites form conjugates with glucuronic and sulfuric acids.
T 1/2 of the plasma is a few minutes.
It is excreted in the urine - 50-60% and with feces - more than 10%. The amount of metabolites that are excreted in the urine varies depending on the phase of the yellow body.
INDICATIONS
Dysfunctional uterine bleeding, metrorrhagia, amenorrhea, habitual miscarriage.
Contraception.
DOSING MODE
Dosing regimen is individual.
Dose, frequency and duration of treatment are determined according to the scheme depending on the indications and the clinical situation.
SIDE EFFECT
From the cardiovascular system: increased blood pressure.

From the side of metabolism: edema.

On the part of the digestive system: violations of the liver, jaundice;
rarely (with prolonged use) - nausea, vomiting.
On the part of the endocrine system: rarely (with prolonged use) - decreased libido, weight gain, pain and tension in the mammary glands, irregular uterine bleeding.

From the side of the central nervous system: rarely (with prolonged use) - headache, depression.

CONTRAINDICATIONS
Severe violations of the liver or kidney function, hepatitis, thromboembolic diseases, vaginal bleeding is not established genesis, breast carcinoma (with the exception of cases in which progesterone is used as part of the combination therapy of the disease).

PREGNANCY AND LACTATION
In cases of extreme necessity, it is possible to use progesterone in pregnancy with established deficiency of the hormones of the yellow body.

Progesterone is not used in women planning pregnancy in the near future.

APPLICATION FOR FUNCTIONS OF THE LIVER
Contraindicated in severe renal dysfunction.
Use with caution in patients with moderate or mild renal impairment.
APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS
Contraindicated in severe violations of liver function, hepatitis.
Use with caution in patients with moderate or mild violations of liver function.
SPECIAL INSTRUCTIONS
They are used with caution in patients with cardiovascular diseases, liver or kidney function disorders, diabetes mellitus, bronchial asthma, epilepsy, migraine, depression.

DRUG INTERACTION
Reduces the intensity of the drugs that stimulate the smooth muscles of the uterus, anabolic steroids, gonadotropic hormones in the anterior lobe of the pituitary gland.

Reduces the lactogenic effect of oxytocin.

Strengthens the action of diuretics, antihypertensive drugs, immunosuppressants.

With simultaneous use with barbiturates, a decrease in the action of progesterone is noted.

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