Universal reference book for medicines
Product name: UPSARIN UPSA (UPSARIN UPSA)

Active substance: acetylsalicylic acid

Type: NSAIDs

Manufacturer: BRISTOL-MYERS SQUIBB (France) distribution in Russia AVENTIS PHARMA (Russia)
Composition, form of production and packaging
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The tablets are effervescent white, round, flat, with bevelled edges and risk on one side; when dissolved in water, gas bubbles are released.
1 tab.

Acetylsalicylic acid 500 mg

Excipients: citric acid anhydrous, sodium carbonate anhydrous, sodium hydrogen carbonate, sodium citrate anhydrous, aspartame, povidone, crospovidone, orange natural flavor.

4 things.
- Strips (4) - packs of cardboard.
INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2014.

PHARMACHOLOGIC EFFECT

NSAIDs.
Has anti-inflammatory, analgesic and antipyretic effects associated with the suppression of COX-1 and COX-2, regulating the synthesis of prostaglandins.Reduces aggregation, platelet adhesiveness and thrombus formation by suppressing the synthesis of thromboxane A 2 in platelets. Antiaggregant effect persists for 7 days after a single dose (more pronounced in men than in women).
Dissolving in water, the Upsarin Oopsa tablet forms a buffer solution which, after administration, maintains the active substances in a dissolved form, preventing them from passing into the undissolved form upon contact with the acidic environment of the stomach and settling in the form of solid particles on its walls.
As a result, faster and more complete absorption of the drug is achieved, as well as its better tolerability compared to conventional acetylsalicylic acid tablets.
PHARMACOKINETICS

Data on the pharmacokinetics of Uppsarin Oopsa are not available.

INDICATIONS

- Moderately or poorly expressed pain syndrome in adults of different origins: headache (including associated with alcohol withdrawal syndrome), toothache, migraine, neuralgia, thoracic syndrome, muscular and joint pain, algodismenorea;

- elevated body temperature for colds and other infectious and inflammatory diseases (in adults and children over 15 years old).

DOSING MODE

To take the drug should dissolve the pill / tablets in a glass (200 ml) of water or juice.

The drug is administered to adults and children older than 15 years , 500 mg (1 tab.) Up to 6 times / day.
With severe pain and high temperature, a single dose can be 1 g (2 tab.). The maximum daily dose is 3 g (6 tablets).
Older patients are prescribed 500 mg (1 tab.) Up to 4 times / day.
The maximum daily dose is 2 g (4 tablets).
The interval between doses of the drug should be at least 4 hours. Regular adherence to the regimen of taking the drug avoids a sharp increase in temperature and reduces the intensity of the pain syndrome.

The duration of treatment (without consulting a doctor) should not exceed 5 days with an appointment as an analgesic and more than 3 days - as an antipyretic.

SIDE EFFECT

Allergic reactions: rarely - skin rash, bronchospasm, Quincke's edema, formation of the "aspirin triad" (combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses and intolerance to acetylsalicylic acid and pyrazolone preparations) on the basis of the hapten mechanism.

From the digestive system: rarely - nausea, vomiting, pain in the epigastric region, diarrhea, gastrointestinal bleeding (vomiting like "coffee grounds", black tarry stools), decreased appetite, increased activity of hepatic transaminases.

From the urinary system: rarely - a violation of kidney function.

From the hemopoietic system: rarely - thrombocytopenia, anemia, leukopenia, hyperbilirubinemia.

From the coagulating system of blood: rarely - hemorrhagic syndrome (epistaxis, bleeding gums), increased coagulation time.

In recommended doses, the drug is usually well tolerated.

The patient should be warned that if side effects develop, stop taking the medication immediately and inform the treating doctor.

CONTRAINDICATIONS

- erosive and ulcerative lesions of the gastrointestinal tract in the phase of exacerbation, gastrointestinal bleeding;

- pronounced violations of the liver function;

- severe renal dysfunction;

- "aspirin" asthma;

- hemorrhagic diathesis (hemophilia, von Willebrand's disease, telangiectasia, hypoprothrombinemia, thrombocytopenia, thrombocytopenic purpura);

- exfoliating aortic aneurysm;

- portal hypertension;

- deficiency of vitamin K;

- deficiency of glucose-6-phosphate dehydrogenase;

- phenylketonuria;

- I and III trimesters of pregnancy;

- the period of lactation (breastfeeding);

- children under the age of 15 with acute respiratory infections caused by viral infections, because of the risk of developing Reye's syndrome (encephalopathy and acute fatty liver disease with acute development of liver failure);

- hypersensitivity to the components of the drug;

- hypersensitivity to other NSAIDs.

With caution , the drug should be used for hyperuricemia, urate nephrolithiasis, gout, peptic ulcer and / or duodenal ulcer (in the anamnesis), decompensated heart failure.

PREGNANCY AND LACTATION

The drug is contraindicated in the I and III trimesters of pregnancy.

If you need to use the drug during lactation, breastfeeding should be discontinued.

APPLICATION FOR FUNCTIONS OF THE LIVER

Contraindicated in cases of severe renal dysfunction.

APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS

Contraindicated use in severe violations of liver function.

APPLICATION FOR CHILDREN

Contraindication: children under the age of 15 with acute respiratory infections caused by viral infections, because of the risk of developing Reye's syndrome (encephalopathy and acute fatty liver disease with acute development of liver failure).

SPECIAL INSTRUCTIONS

Acetylsalicylic acid reduces the excretion of uric acid from the body, which can cause an acute attack of gout in predisposed patients.

With prolonged use of the drug should periodically conduct a general blood test and analysis of feces for latent blood, monitor the functional state of the liver.

Before surgery, to reduce bleeding during surgery and in the post-operation period, you should cancel taking the drug for 5-7 days and inform the doctor.

Patients who follow a salt-free or low-salt diet should note that each tablet contains 388.5 mg (16.9 mEq) of sodium.

Use in Pediatrics

Children should not be prescribed drugs containing acetylsalicylic acid, because in the case of a viral infection, the risk of developing Reye syndrome increases.Symptoms of Reye's syndrome include prolonged vomiting, acute encephalopathy, and enlargement of the liver.

OVERDOSE

Symptoms: in the initial stage of poisoning, the symptoms of CNS excitement, dizziness, severe headache, decreased severity of hearing, visual impairment, nausea, vomiting, increased respiration.
Later there comes depression of consciousness up to a coma, respiratory insufficiency, disturbances of a water-electrolyte exchange.
Treatment: Vomiting or gastric lavage, prescribing activated charcoal and laxative.
Treatment should be carried out in a specialized department.
DRUG INTERACTION

Acetylsalicylic acid increases the toxicity of methotrexate, the effects of opioid analgesics, other NSAIDs, oral hypoglycemic drugs, heparin, indirect anticoagulants, thrombolytic agents and platelet aggregation inhibitors, sulfonamides (including co-trimoxazole), and triiodothyronine.

Acetylsalicylic acid reduces the toxicity of uricosuric drugs (benzbromarone, sulfinpyrazone), hypotensive drugs and diuretics (spironolactone, furosemide).

SCS, ethanol and ethanol containing drugs increase the damaging effect of acetylsalicylic acid on the mucosa of the gastrointestinal tract, increase the risk of developing gastrointestinal bleeding.

Acetylsalicylic acid increases the concentration of digoxin, barbiturates and lithium preparations in blood plasma.

Antatsida, containing magnesium and / or aluminum hydroxide, slow down and worsen the absorption of acetylsalicylic acid.

TERMS OF RELEASE FROM PHARMACY

The drug is approved for use as a means of OTC.

TERMS AND CONDITIONS OF STORAGE

The drug should be stored out of reach of children, dry, out of reach of children at a temperature of no higher than 30 ° C.
Shelf life - 3 years.
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