Universal reference book for medicines
Name of the drug: UNITIOL-BINERGIA (UNITHIOL-BINERGIA)

Active substance: nonappropriate

Type: Antidote.
Donator of sulfhydryl (thiol) groups
Manufacturer: BINERGY (Russia) produced ARMAVIR BIOFABRIKA (Russia)
Composition, form of production and packaging
Solution for / m and s / to the introduction of a
transparent, colorless or pinkish color with a weak smell of hydrogen sulfide.

1 ml

sodium dimercaptopropanesulfonate monohydrate (unitiol) 50 mg

Auxiliary substances: water d / and up to 1 ml.

5 ml - glass ampoules (5) - contour plastic packaging (1) - cardboard packs.

5 ml - glass ampoules (5) - contour plastic packaging (2) - cardboard packs.

5 ml - ampoules glass (5) - packings contour mesh (1) - packs cardboard.

5 ml - ampoules glass (5) - packings contour mesh (2) - packs cardboard.

5 ml - ampoules glass (5) complete with a knife ampoule or scarifier ampoule - packages contour plastic (1) - packs cardboard.

5 ml - ampoules glass (5) complete with a knife ampoule or ampoule scarifier - packings contour plastic (2) - packs cardboard.

5 ml - ampoules glass (5) complete with a knife ampoule or ampoule scarifier - packings contour mesh (1) - packs cardboard.

5 ml - ampoules glass (5) complete with a knife ampoule or scarifier ampoule - packings contour mesh (2) - packs cardboard.

5 ml - glass ampoules (5) - contour plastic packaging (25) - cardboard boxes.

5 ml - glass ampoules (5) - contour plastic packaging (50) - cardboard boxes.

5 ml - glass ampoules (5) - contour plastic packaging (100) - cardboard boxes.

5 ml - glass ampoules (5) - contoured cellular packaging (25) - cardboard boxes.

5 ml - glass ampoules (5) - contoured cellular packaging (50) - cardboard boxes.

5 ml - glass ampoules (5) - contoured cellular packaging (100) - cardboard boxes.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2014.

PHARMACHOLOGIC EFFECT

Complexing agent, has detoxification effect.
Active sulfhydryl groups, reacting with thiol poisons and forming non-toxic compounds with them, restore the functions of the enzyme systems of the organism affected by poison. Increases the excretion of certain cations (especially Cu 2+ and Zn 2+) from metal-containing enzymes of cells.
With diabetic polyneuropathy reduces irritative pain syndrome, improves the condition of the peripheral nervous system and normalizes the permeability of capillaries.

PHARMACOKINETICS

When parenteral administration is rapidly absorbed into the blood.
C max in the blood plasma is reached after 15-30 minutes after the / m injection. T 1/2 - 1-2 hours Excreted by the kidneys, mainly in the form of products of partial or partial oxidation, in part - in unchanged form.
INDICATIONS

- intoxication with arsenic, mercury, bismuth, chromium and cardiac glycosides;

- hepato-cerebral dystrophy (Wilson-Westfal-Konovalov's disease);

- diabetic polyneuropathy;

- chronic alcoholism (as part of complex therapy);

- delirious psychosis.

DOSING MODE

V / m, sc / k.

At an intoxication with arsenic - 250-500 mg (5-10 ml of the preparation), at the rate of 50 mg / 10 kg, in the 1st day - 3-4 times, in the second day - 2-3 times, in the subsequent - on 1-2 times.

When poisoning with mercury compounds - according to the same scheme for 6-7 days.
Treatment is carried out until the signs of intoxication disappear.
When digital intoxication in the first 2 days, 250-500 mg (5-10 ml of the drug) are injected 3-4 times / day, then 1-2 times / day until the cardiotoxic effect stops.

With hepatocerebral dystrophy - in / m 250-500 mg (5-10 ml of the drug) daily or every other day;
course of treatment - 25-30 injections; if necessary, repeat after 3-4 months.
With chronic alcoholism, 150-250 mg (3-5 ml of the drug) are prescribed 2-3 times a week.

To relieve delirium - once 200-250 mg (4-5 ml of the drug).

With diabetic polyneuropathy - in / m, 250 mg (5 ml of the drug), the course of treatment - 10 injections.

SIDE EFFECT

Nausea, vomiting, dizziness, tachycardia, pallor of the skin, increased blood pressure, anxiety.

CONTRAINDICATIONS

- liver failure;

- arterial hypertension;

- Pregnancy;

- lactation period;

- children's age till 18 years;

- Hypersensitivity.

PREGNANCY AND LACTATION

Contraindicated in pregnancy and lactation.

APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS

Contraindicated in liver failure.

APPLICATION FOR CHILDREN

Contraindicated in children under 18 years.

SPECIAL INSTRUCTIONS

In acute poisoning, additional therapeutic measures are carried out (gastric lavage, oxygen therapy, dextrose administration, etc.).

Influence on ability to drive vehicles, mechanisms

There are no data confirming the influence of Unitiol-Binergia on the ability to engage in potentially hazardous activities requiring increased attention.

OVERDOSE

In the recommended doses and on the evidence of overdose phenomena does not arise.

If the recommended therapeutic dose is exceeded, dyspnea, hyperkinesia, blocking, lethargy, dizziness, short-term convulsions are observed 10 times.

Treatment: symptomatic therapy.

DRUG INTERACTION

It is not recommended simultaneous use of Unithiol with preparations containing heavy metals and alkalis, as the rapid decomposition of Unithiol occurs.

TERMS OF RELEASE FROM PHARMACY

On prescription.

TERMS AND CONDITIONS OF STORAGE

Keep the drug in a dark place at a temperature of no higher than 25 ° C.
Keep out of the reach of children. Shelf life - 5 years.
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