Universal reference book for medicines
Product name: UNITIOL (UNITHIOL)

Active substance: nonappropriate

Type: Antidote.
Donator of sulfhydryl (thiol) groups
Manufacturer: MOSHIMFARMPREPARATY them.
N.А. Semashko OJSC (Russia)
Composition, form of production and packaging
Solution for the / m and s / to the introduction of a
transparent, colorless or pinkish color, with a faint smell of hydrogen sulfide.

1 ml of 1 amp.

sodium dimercaptopropanesulfonate monohydrate (unitiol) 50 mg 250 mg

Excipients: disodium edetate (trilon B) 100 μg, sulfuric acid 0.1 M (to pH 3.1-4.5), water d / u (up to 1 ml).

5 ml - ampoules glass (5) - packings contour mesh (2) - packs cardboard.

INSTRUCTION FOR THE SPECIALIST.

The product description was approved by the manufacturer for the 2009 print edition.

PHARMACHOLOGIC EFFECT

Complexing agent, has detoxification effect.
The active sulfhydryl groups of unithiol, reacting with thiol poisons (arsenic compounds, heavy metal salts) and forming with them nontoxic, water-soluble compounds, restore the functions of the enzyme systems of the organism affected by the poison. With diabetic polyneuropathy reduces pain syndrome, improves the state of the peripheral nervous system and normalizes the permeability of capillaries.
PHARMACOKINETICS

When parenteral administration is rapidly absorbed into the blood.
C max is reached after 15-30 minutes after a / m injection. T 1/2 - 1-2 hours Excreted by the kidneys, mainly in the form of incomplete and complete oxidation products, partially unchanged.
INDICATIONS

- intoxication with arsenic, mercury, bismuth, chromium, cardiac glycosides;

- hepatocerebral dystrophy (Wilson-Konovalov's disease);

- diabetic polyneuropathy;

- chronic alcoholism (as part of complex therapy);

- delirious psychosis.

DOSING MODE

V / m, sc / k.

At an intoxication with arsenic - 5-10 ml of a preparation (at the rate of 0.005 g / 1 kg), in 1 day - 3-4 times, on 2 day - 2-3 times, in the subsequent - 1-2 times.

When poisoning with mercury compounds - according to the same scheme for 6-7 days.
Treatment is carried out until the signs of intoxication disappear.
With digitalis intoxication in the first 2 days, 5-10 ml of 5% aqueous solution 3-4 times / day, then 1-2 times / day until the cardiotoxic action ceases.

With hepatocerebral dystrophy - in / m 5-10 ml of 5% solution daily or every other day;
course of treatment - 25-30 injections; if necessary, repeat after 3-4 months.
With chronic alcoholism prescribe 3-5 ml 2-3 times a week.

For relief of delirium - once 4-5 ml.

SIDE EFFECT

Nausea, dizziness, tachycardia, pallor of the skin.

Allergic reactions are possible.

CONTRAINDICATIONS

- liver failure;

- arterial hypertension;

- Hypersensitivity to the drug.

APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS

Contraindicated in liver failure.

SPECIAL INSTRUCTIONS

In acute poisoning, along with the administration of the drug, gastric lavage, oxygen therapy, and glucose administration are performed.

OVERDOSE

In the recommended doses and on the evidence of overdose phenomena does not arise.

DRUG INTERACTION

It is not recommended simultaneous use of unithiol with drugs, which include heavy metals and alkalis, t.
there is a rapid decomposition of unithiol.
TERMS OF RELEASE FROM PHARMACY

The drug is released by prescription.

TERMS AND CONDITIONS OF STORAGE

List B. Keep out of the reach of children, protected from light at a temperature of 0 ° to 25 ° C.
Shelf life - 5 years.
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