Universal reference book for medicines
Product name: THERAFLU В® (THERAFLU В® )

Active substance: paracetamol, pheniramine, phenylephrine

Type: The drug for symptomatic therapy of acute respiratory diseases

Manufacturer: GlaxoSmithKline Helsker (Russia) manufactured by NOVARTIS CONSUMER HEALTH (USA)
Composition, form of production and packaging
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Powder for the preparation of a solution for ingestion (forest fruits) loose, consisting of granules of white, yellowish, pinkish and gray-violet; soft lumps are allowed; prepared aqueous solution of pink-violet, opaque, with a berry smell.
1 pack.

paracetamol 325 mg

Pheniramine maleate 20 mg

phenylephrine hydrochloride 10 mg

[PRING] sucrose 10,000 mg, acesulfame potassium 13 mg, red dye red (E129) (dye FD & C red No. 40) 2.4 mg, blue color dye (E133) (dye FD & C blue No. 1) 0.3 mg, maltodextrin M100 - 26 mg, silicon dioxide - 13 mg, natural raspberry aroma WONF Durarome (860385 TD0994) - 165 mg, natural cranberry flavoring Durarome (861149 TD2590) - 55 mg, citric acid - 725 mg, sodium citrate dihydrate 180 mg, calcium phosphate - 35 mg, magnesium stearate - 3.2 mg.

11.5 g - multi-layer sachets (10) - packs of cardboard.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2010.

PHARMACHOLOGIC EFFECT

Combined drug, has antipyretic, anti-edematous, analgesic and antiallergic effect.

INDICATIONS

- Infectious and inflammatory diseases - influenza, acute respiratory infections ("colds"), accompanied by fever, chills and fever, headache, runny nose, stuffy nose, sneezing and muscle aches.

DOSING MODE

Inside.
The contents of the sachet are dissolved in 1 glass of boiled hot water. Used in hot condition. You can add sugar to taste. Repeated dose can be taken every 4 hours (no more than 3 doses in 24 hours). TeraFlu В® can be used at any time of the day, but the best effect comes from taking the drug before going to bed, at night. If there is no relief of symptoms within 3 days after starting the drug, you should see a doctor.
SIDE EFFECT

Possible allergic reactions (skin rash, itching, hives, angioedema), increased excitability, sleep disturbance, decreased speed of psychomotor reactions, drowsiness, dizziness, nausea, vomiting, stomach pain, palpitations, increased blood pressure, dry mouth, paresis of accommodation , increased intraocular pressure, and retention of urine.

With long-term use in large doses of hepatotoxic effects, violations of the blood picture (anemia, thrombocytopenia, agranulocytosis), nephrotoxicity.

CONTRAINDICATIONS

- simultaneous reception of tricyclic antidepressants, monoamine oxidase (MAO) inhibitors, beta-blockers;

- portal hypertension;

- Alcoholism;

- diabetes;

- Pregnancy and the period of breastfeeding;

- children's age till 12 years;

- Hypersensitivity to individual components of the drug.

With caution: with pronounced arteriosclerosis of the coronary arteries, with arterial hypertension, angle-closure glaucoma, severe liver or kidney disease, prostatic hyperplasia, blood diseases, glucose-6-phosphate dehydrogenase deficiency, congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson and Rother syndrome), hyperthyroidism , pheochromocytoma, bronchial asthma.

PREGNANCY AND LACTATION

Contraindicated during pregnancy and lactation.

APPLICATION FOR FUNCTIONS OF THE LIVER

With caution: severe kidney disease.

APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS

With caution: severe liver disease.

APPLICATION FOR CHILDREN

Contraindicated in children under 12 years.

OVERDOSE

Nausea, vomiting, pain in the epigastric region, hepatotoxic and nephrotoxic effect, in severe cases - hepatic insufficiency, hepatonecrosis, increased activity of "liver" transaminases, increased prothrombin time, encephalopathy and coma.

Treatment: gastric lavage, reception of activated charcoal, symptomatic therapy.
The introduction of methionine after 8-9 hours after an overdose and acetylcysteine ​​- after 12 hours. Seek medical attention.
DRUG INTERACTION

Strengthens the effects of MAO inhibitors, sedatives, ethanol.
The risk of hepatotoxic effects of paracetamol increases with the simultaneous use of barbiturates, phenytoin, carbamazepine, rifampicin, zidovudine and other inducers of microsomal liver enzymes.
Antidepressants, antiparkinsonics, antipsychotics, phenothiazine derivatives - increase the risk of urinary retention, dry mouth, constipation.
Glucocorticosteroids increase the risk of increased intraocular pressure.
Paracetamol reduces the effectiveness of uricosuric drugs and improves the effectiveness of indirect anticoagulants.

Tricyclic antidepressants enhance the sympathomimetic effect, the simultaneous administration of halothane increases the risk of ventricular arrhythmia.
FROM
Reduces the hypotensive effect of guanethidine, which, in turn, enhances the alpha-adrenostimulating activity of phenylephrine.

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