Universal reference book for medicines
Product name: TEKSAMEN (TEKSAMEN)

Active substance: tenoxicam

Type: NSAIDs

Manufacturer: MUSTAFA NEVZAT ILAC SANAYII (Turkey)
Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..

PHARMACHOLOGIC EFFECT
NSAIDs of oxycam.
Has a powerful analgesic and anti-inflammatory effect, antipyretic effect is less pronounced. The mechanism of action is based on inhibition of the activity of COX-1 and COX-2 isoenzymes, as a result of which the synthesis of prostaglandins in the inflammatory focus and other body tissues is reduced. In addition, tenoxicam reduces the accumulation of leukocytes in the inflammatory focus. A distinctive feature of tenoxicam is a long duration of action. Its T 1/2 is 72 h.
INDICATIONS
Osteoarthritis, myalgia, neuralgia, radicular syndrome.

DOSING MODE
For oral, IV, IM or rectally, the dose is 20 mg 1 time / day.
In the case of acute processes, the duration of the course of treatment is 7-14 days. Parenteral is used when there is no possibility of oral administration.
SIDE EFFECT
From the digestive system: most often - erosive and ulcerative lesions of the digestive tract, diarrhea, abdominal pain, nausea, vomiting, flatulence, gastritis, esophagitis;
bleeding from erosions, ulcers, as well as rectal and hemorrhoidal hemorrhages, which is a consequence of inhibition of thromboxane A 2 synthesis; an increase in the activity of transaminases in the blood.
On the part of the hemopoietic system: a decrease in hemoglobin, not related to bleeding, anemia, thrombocytopenia, leukopenia, eosinophilia.

On the part of metabolism: hyperglycemia, reversible increase in urea nitrogen and creatinine in blood plasma.

From the central nervous system and peripheral nervous system: headache, dizziness, tremor, agitation, insomnia or drowsiness, irritation and puffiness of the eyelids (with normal ophthalmoscopic results), paresthesia.

Allergic reactions: Lyell's syndrome, Stevens-Johnson syndrome, hives, itching.

Dermatological reactions: alopecia, photosensitization, changes in nails, and netrombotsitopenicheskaya purpura.

CONTRAINDICATIONS
Erosive-ulcerative lesions of the gastrointestinal tract in the phase of exacerbation, indications in the anamnesis for peptic ulcer of stomach and duodenum, bleeding from the digestive tract, pregnancy, lactation (breastfeeding), hypersensitivity to tenoxicam and other NSAIDs.

PREGNANCY AND LACTATION
Tenoxicam is contraindicated in pregnancy and lactation.

Due to the use of tenoxicam during pregnancy, lengthening of pregnancy, delay in labor and weak labor activity (as a result of a decrease in the synthesis of prostaglandins stimulating the rhythmic contractile activity of the myometrium) is possible.

APPLICATION FOR FUNCTIONS OF THE LIVER
Use with caution in patients with impaired renal function (including those caused by diabetes mellitus).
Prostaglandins synthesized in the kidneys regulate the volumetric flow in the renal parenchyma. If the synthesis of prostaglandins under the influence of tenoxicam, development of a decrease in renal blood flow is possible, leading to the phenomena of renal failure, as well as to interstitial nephritis, glomerulonephritis, papillary necrosis and nephrotic syndrome. Especially caution should be used tenoxicam on the background of treatment with diuretics or potentially nephrotoxic drugs.
For renal failure, patients with QC greater than 25 ml / min require careful monitoring of the physician without correction of the dosing regimen.
Clinical data on the use of tenoxicam in patients with SC less than 25 ml / min are limited.
APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS
Use with caution in patients with impaired hepatic function.
If against the background of the use of tenoxicam there is an excessive increase in the level of transaminases, which persists during therapy, then tenoxicam should be discontinued.
SPECIAL INSTRUCTIONS
When applying tenoxicam, the function of the digestive tract should be carefully monitored.
If the first signs of ulcerogenesis or gastrointestinal bleeding are discovered, tenoxicam should be immediately withdrawn.
Use with caution in patients with impaired renal function (including those caused by diabetes mellitus).
Prostaglandins synthesized in the kidneys regulate the volumetric flow in the renal parenchyma. If the synthesis of prostaglandins under the influence of tenoxicam, development of a decrease in renal blood flow is possible, leading to the phenomena of renal failure, as well as to interstitial nephritis, glomerulonephritis, papillary necrosis and nephrotic syndrome. Especially caution should be used tenoxicam on the background of treatment with diuretics or potentially nephrotoxic drugs.
For renal failure, patients with QC greater than 25 ml / min require careful monitoring of the physician without correction of the dosing regimen.
Clinical data on the use of tenoxicam in patients with SC less than 25 ml / min are limited.
Use with caution in patients with impaired hepatic function.
If against the background of the use of tenoxicam there is an excessive increase in the level of transaminases, which persists during therapy, then tenoxicam should be discontinued.
Tenoxicam is capable of retaining potassium, sodium, and water ions.
In this regard, tenoxicum can worsen the course of hypertension or heart failure.
Tenoxicam reduces platelet aggregation and increases bleeding time, which should be borne in mind in the upcoming surgical interventions.

It is not recommended to use tenoxicam in combination with salicylates.

DRUG INTERACTION
In connection with the fact that tenoxicam is able to cause a decrease in lithium excretion, patients who receive lithium preparations may experience intoxication.

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