Universal reference book for medicines
Product name: TEKNAZOL (TEKNAZOL)

Active substance: itraconazole

Type: Antifungal medication

Manufacturer: NOBEL ILAC SANAYII AND TICARET (Turkey)
Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..

PHARMACHOLOGIC EFFECT
Antifungal agent, a derivative of triazole.
The mechanism of action is associated with the ability to inhibit cytochrome P450-dependent enzymes of sensitive fungi, which leads to a disruption in the synthesis of ergosterol of the fungal cell wall. It has a broader spectrum of antifungal activity than ketoconazole. It is active against Aspergillus spp., Blastomyces dermatitidis, Candida, Coccidioides immitis, Cryptococcus neoformans, Epidermophyton, Microsporum, Trichophyton, Histoplasma capsulatum, Malassezia furfur, Paracoccidioides brasiliensis, Sporothrix schenckii.
PHARMACOKINETICS
Therapeutic concentrations in the skin persist for 2-4 weeks after the end of the 4-week course of treatment.
Itraconazole is determined in the nail keratin a week after the start of treatment and persists for 6 months after the end of the 3-month course of therapy.
INDICATIONS
Vulvovaginal candidiasis, skin mycoses, oral cavity, eyes, onychomycosis caused by dermatophytes and / or yeast, systemic mycoses (including systemic aspergillosis, candidiasis, cryptococcosis, histoplasmosis, sporotrichosis, paracoccidioidosis, blastomycosis and other seldom occurring systemic and tropical mycoses).

DOSING MODE
Inside to 100 mg 1 time / day or 200 mg 1-2 times / day, the duration of treatment depends on the etiology of the disease.

SIDE EFFECT
From the side of the digestive system: abdominal pain, nausea, vomiting, constipation, increased activity of liver enzymes, cholestatic jaundice;
in some cases - hepatitis.
From the side of the central nervous system and peripheral nervous system: headache, dizziness;
in some cases - peripheral neuropathy.
From the cardiovascular system: in some cases - swelling, congestive heart failure and pulmonary edema.

Allergic reactions: skin rash, itchy skin, urticaria, angioedema, Stevens-Johnson syndrome.

Other: with prolonged use - dysmenorrhea, hair loss, hypokalemia.

CONTRAINDICATIONS
Simultaneous ingestion of terfenadine, astemizole, misolastine, cisapride, dofetilide, quinidine, pimozide, simvastatin, lovastatin, midazolam or triazolam;hypersensitivity to itraconazole.

PREGNANCY AND LACTATION
In pregnancy, itraconazole is used only in systemic fungal infections, when the expected effect of therapy exceeds the potential risk to the fetus.

Women of childbearing age are recommended to use contraceptives during the use of itraconazole.

If it is necessary to use during the lactation period, the question of stopping breastfeeding should be solved.

In experimental studies , itraconazole has an embryotoxic effect and causes fetal development abnormalities.

APPLICATION FOR FUNCTIONS OF THE LIVER
In cases of extreme need for renal dysfunction, itraconazole treatment is administered under the control of its plasma level and with appropriate dose adjustment.

APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS
Do not use itraconazole in patients with liver disease.
However, in cases of extreme need for cirrhosis, itraconazole treatment is administered under the control of its plasma level and with appropriate dose adjustment.
When the activity of liver transaminase increases, itraconazole is used in cases where the expected benefit of therapy exceeds the possible risk of liver damage.

If itraconazole is used for more than 1 month, liver function control is necessary.

When developing against the background of treatment of symptoms of liver function disorders itraconazole should be discontinued.

APPLICATION FOR CHILDREN
Currently, there is insufficient data on the use of itraconazole in children.

SPECIAL INSTRUCTIONS
Do not use in patients with symptoms of ventricular dysfunction and history of congestive heart failure.

Do not use itraconazole in patients with liver disease.
However, in cases of extreme need for cirrhosis and / or renal dysfunction, itraconazole treatment is administered under the control of its plasma level and with appropriate dose adjustment.
When the activity of liver transaminase increases, itraconazole is used in cases where the expected benefit of therapy exceeds the possible risk of liver damage.

If itraconazole is used for more than 1 month, liver function control is necessary.

When developing against the background of treatment of symptoms of heart failure, violations of liver function, peripheral neuropathy itraconazole should be abolished.

With caution apply itraconazole with increased sensitivity to other azole derivatives.

Use in Pediatrics

Currently, there is insufficient data on the use of itraconazole in children.

DRUG INTERACTION
The drugs that cause the induction of liver enzymes (rifampicin, phenytoin) can reduce the concentration of itraconazole in the plasma.

With simultaneous use with drugs that reduce the acidity of gastric juice (including m-holinoblokatory, antacids, blockers of histamine H 2 -receptors), it is possible to reduce the absorption of itraconazole.

When used simultaneously with drugs metabolized with the participation of CYP3A isoenzymes, it is possible to increase the intensity and / or duration of their effects.
These drugs include terfenadine, astemizole, cisapride, midazolam, triazolam (for oral administration), indirect anticoagulants, cyclosporine, digoxin, calcium channel blockers, quinidine, vincristine.

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