Universal reference book for medicines
Product name: TANTUM ® VERDE (TANTUM VERDE)

Active substance: benzydamine

Type: NSAIDs for topical application in ENT practice and dentistry

Manufacturer: Aziende Chimiche Riunite Angelini Francesco ACRAF (Italy)
Composition, form of production and packaging
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Spray for topical use dosed in the form of a colorless transparent liquid with a characteristic smell of mint.
1 dose of 100 ml

benzidamine hydrochloride 255 μg 150 mg

[PRING] ethanol 96%, glycerol, methyl parahydroxybenzoate, menthol flavor, saccharin, sodium bicarbonate, polysorbate 20, purified water.

30 ml (176 doses) - polyethylene bottles with pump and pressure device with folding cannula (1) - packs cardboard.

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Solution for topical application 0.15% transparent, green, with a characteristic smell of mint.
100 ml

benzidamine hydrochloride 150 mg

[PRING] ethanol 96%, glycerol, methyl parahydroxybenzoate, menthol flavor, saccharin, sodium bicarbonate, polysorbate 20, quinoline yellow dye 70% (E104), blue patented 85% (E131), purified water.

120 ml - bottles of glass (1) complete with a graduated polypropylene cup (15 and 30 ml) - packs of cardboard.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2014.

PHARMACHOLOGIC EFFECT

NSAIDs from the group of indazoles for topical application in ENT practice and in dentistry.
Has anti-inflammatory and local analgesic effect. The mechanism of action of the drug is associated with the stabilization of cell membranes and the inhibition of the synthesis of prostaglandins.
When applied locally, the drug is well absorbed through the mucous membranes and penetrates into inflamed tissues.

PHARMACOKINETICS

Benzimidine is excreted by the kidneys and through the intestines.

INDICATIONS

Inflammatory diseases of the oral cavity and ENT organs:

- gingivitis, glossitis, stomatitis (including after radiation and chemotherapy);

- angina, pharyngitis, laryngitis, tonsillitis;

Candidiasis (as part of combination therapy);

- calculous inflammation of the salivary glands;

- after surgical interventions and traumas (including tonsillectomy, jaw fractures);

- after treatment or removal of teeth;

- Parodontosis.

With infectious and inflammatory diseases, the use of Tantum Verde in the combination therapy is necessary.

DOSING MODE

Tablets for resorption appoint 1 tab.
3-4 times / day.
A topical solution is used for 1 tablespoon (15 ml) of mouthwash or throat every 1.5-3 h to relieve pain.
After rinsing, the solution must be spit out.
Adults (including elderly people) are prescribed 4-8 doses of spray every 1.5-3 hours. Children aged 6-12 years - 4 doses;
Children younger than 6 years of age are given a dose of 1 dose for every 4 kg of body weight (maximum 4 doses) every 1.5-3 hours.
SIDE EFFECT

Local reactions: dry mouth, numbness, burning in the mouth.

Allergic reactions: skin rash.

Other: drowsiness.

CONTRAINDICATIONS

- Children under 12 years of age (for topical solution);

- phenylketonuria (for tablets);

- Hypersensitivity to the components of the drug.

PREGNANCY AND LACTATION

It is possible to use the drug during pregnancy and lactation (breastfeeding) according to the indications.

APPLICATION FOR CHILDREN

The drug is contraindicated for children under 12 years (for a solution for topical application).

Children aged 6-12 years - 4 doses;
Children younger than 6 years of age are given a dose of 1 dose for every 4 kg of body weight (maximum 4 doses) every 1.5-3 hours.
SPECIAL INSTRUCTIONS

Avoid contact with the eyes.

If a burning sensation occurs during application of the solution, the solution should be diluted 2 times with water by adjusting the water level to the risks in the graduated cup.

OVERDOSE

At present, no cases of an overdose of Tantum Verde were reported.

DRUG INTERACTION

Clinically significant drug interaction of the drug Tantum Verde has not been established.

TERMS OF RELEASE FROM PHARMACY

The drug is approved for use as a means of OTC.

TERMS AND CONDITIONS OF STORAGE

The drug should be stored in a place protected from light, inaccessible to children, at a temperature of no higher than 25 ° C.
Shelf life - 4 years.
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