Universal reference book for medicines
Name of the drug: TAZEPAM (TAZEPAM)

Active substance: oxazepam

Type: Tranquilizer (anxiolytic)

Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..

Anxiolytic agent (tranquilizer) from the group of benzodiazepine derivatives.
Has anxiolytic and sedative effect. Has anticonvulsant and central muscle relaxant activity. The mechanism of action is associated with the enhancement of GABA-ergic processes in the brain. It mainly affects the activating network formation of the brain, reducing the perception of impulses from sensitive receptors to the limbic system and reducing the emotional coloration.
After intake, absorbed slowly, fully.
Binding to plasma proteins is 97%. C max is achieved after 1-4 hours and is 450 ng / ml after taking a dose of 30 mg. It penetrates the GEB, the placental barrier, into breast milk. Metabolised in the liver with the formation of glucuronides, which do not have pharmacological activity. T 1/2 - 5-15 hours. It is excreted by the kidneys and with feces. C ss is noted after 1-3 days of treatment. Accumulation with a reappointment is minimal (refers to benzodiazepines with short and medium T 1/2 ), excretion after cessation of treatment is rapid.
Neuroses, sleep disorders, psycho vegetative disorders.
Vegetative disorders in women associated with menstrual disorders or menopause, as well as with pronounced premenstrual syndrome. Reactive depression (as part of combination therapy).
Established individually, depending on the indications and the development of therapeutic effect.
The daily dose varies from 10 to 120 mg. The duration of treatment is determined individually. The therapy should be completed gradually.
From the side of the central nervous system and the peripheral nervous system: at the beginning of treatment (especially in elderly patients) drowsiness, dizziness, fatigue, impaired concentration, ataxia, gait instability and poor coordination of movements, lethargy, dullness of emotions, slowing of mental and motor reactions;rarely - headache, euphoria, depression, tremor, mood depression, numbness, memory impairment, dystonic extrapyramidal reactions (uncontrolled movements, including the eye), weakness, muscle weakness during the day, dysarthria (blurred speech), confusion ;
extremely rare - paradoxical reactions (aggressive outbreaks, psychomotor agitation, fear, suicidal tendencies, muscle spasm, hallucinations, acute agitation, irritability, anxiety, insomnia).
On the part of the hematopoiesis system: leukopenia, neutropenia, agranulocytosis (chills, hyperthermia, sore throat, unusual fatigue or weakness), anemia, thrombocytopenia.

On the part of the digestive system: dry mouth or salivation, heartburn, nausea, vomiting, anorexia, constipation, diarrhea, impaired liver function, increased activity of hepatic transaminases and alkaline phosphatase, jaundice.

From the urinary system: urinary incontinence, urinary retention, impaired renal function.

On the part of the reproductive system: increased or decreased libido, dysmenorrhea.

Allergic reactions: skin rash, itching.

Influence on the fetus: teratogenicity, CNS depression, respiratory failure and suppressing the sucking reflex in newborns whose mothers used the drug.

Other: addiction, drug dependence, lowering blood pressure;
rarely - depression of the respiratory center, impaired vision (diplopia), bulimia, weight loss, tachycardia, anterograde amnesia.
With a sharp decrease in dose or withdrawal, withdrawal syndrome (irritability, headache, anxiety, excitement, anxiety, nervousness, sleep disturbance, dysphoria, spasm of smooth muscles of the internal organs and skeletal muscles, depersonalization, increased sweating, depression, nausea, vomiting , tremor, perceptual disorders, including hyperaemia, paresthesia, photophobia, tachycardia, convulsions, hallucinations, rarely - acute psychosis).

Coma, shock, acute alcohol intoxication with impaired vital functions, acute intoxication with drugs that exert a depressing effect on the central nervous system (narcotic, hypnotics and psychotropic drugs), myasthenia gravis, angle-closure glaucoma (acute attack or predisposition), severe COPD (progression of the degree of respiratory failure) , acute respiratory failure, severe depression (suicidal tendencies may occur), pregnancy (especially I trimester), lactation (breastfeeding), child
age to 6 years, hypersensitivity to oxazepam.
Oxazepam has a toxic effect on the fetus and increases the risk of developing congenital malformations when used in the first trimester of pregnancy.
Taking therapeutic doses at a later time of pregnancy can cause depression of the newborn's central nervous system. Continuous use during pregnancy can lead to physical dependence with the development of withdrawal syndrome in a newborn. Children, especially at a young age, are very sensitive to the CNS depressing action of benzodiazepines. The use immediately before childbirth or during childbirth can cause a respiratory depression in the newborn, a reduction in muscle tone, hypotension, hypothermia, and a sluggish suckling syndrome in a newborn. Contraindicated during lactation.
Use with caution in renal failure.

Use with caution in liver failure.

Contraindicated in children under 6 years.

Use with caution in elderly patients.

Any change in the dose should be controlled by a doctor.

They are used with caution in patients with arterial hypotension, with increased risk of drug dependence, in elderly patients, with hepatic and / or renal insufficiency, cerebral and spinal ataxia, hyperkinesis, propensity to abuse psychotropic drugs, organic brain diseases, psychosis (possible paradoxical reactions), hypoproteinemia, nocturnal apnea (established or suspected).

Oxazepam should not be used for a long time (for several months) due to the possibility of developing drug dependence.
With prolonged treatment, it is necessary to monitor liver function and the state of peripheral blood.
Impact on the ability to drive vehicles and manage mechanisms

During the treatment period, vehicles should not be driven and other potentially hazardous activities that require increased attention;
do not drink alcohol.
With simultaneous use with oral contraceptives, the effectiveness of oxazepam decreases.

With simultaneous application, the bioavailability of zidovudine is moderately increased and the incidence of headache increases.

With simultaneous use with phenytoin, there is a risk of a decrease in the concentration of oxazepam in the blood plasma.

With simultaneous use with ethanol, the depressing effect on the central nervous system increases.

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