Universal reference book for medicines
Product name: SEMAX ® (SEMAX)

Active substance: nonappropriate

Type: Nootropic preparation

Manufacturer: PEPTOGEN Innovative Research and Production Center (Russia)
Composition, form of production and packaging
Nasal drops
1 ml

methionyl-glutamyl-histidyl-phenylalanyl-prolyl-glycyl-proline 10 mg

3 ml - vials (1) complete with a stopper-pipette - packs cardboard.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2014.

PHARMACHOLOGIC EFFECT

Semax has an original mechanism of neurospecific action on the central nervous system (CNS).
Semax is a synthetic analog of corticotropin, which possesses nootropic properties and is completely devoid of hormonal activity. The drug improves cognitive, or cognitive processes of the brain, such as memory, learning. Attention. Increases mental performance; improves the adaptation of brain cells to hypoxia, anesthesia and other damaging effects. The drug is virtually non-toxic for a single and long-term administration. Does not show allergic, embryotoxic, teratogenic and mutagenic properties. Does not have a local irritant effect.
PHARMACOKINETICS

Absorbed from the mucous membrane of the nasal cavity, while digesting up to 60-70% in terms of the active substance.
Semax is quickly distributed to all organs and tissues, it penetrates the blood-brain barrier. Upon entering the blood, Semax undergoes a fairly rapid biotransformation and excretion from the body with urine.
INDICATIONS

- an acute period of ischemic stroke of moderate and severe degree in the composition of complex therapy.

DOSING MODE

Semax is applied intranasally using a vial capped with a plastic stopper pipet.

The volume of one drop is 0.05 ml (50 μl).
One drop of the standard solution contains 500 μg of active substance.
For a stroke of medium severity, 2-3 drops are injected into each nostril at a time, which is 2000 μg (4 drops or 0.2 ml) - 3000 μg (6 drops or 0.3 ml).
Burying is carried out 3-4 times a day, with an interval between stabbing 3-4 hours. The daily dose is 6000 μg (12 drops or 0.6 ml) - 12,000 μg (24 drops or 1.2 ml).
In severe strokes , 3-4 drops are injected into each nostril at a time, which is 3000 μg (6 drops or 0.3 m) - 4000 μg (8 drops or 0.4 ml).
Burial is carried out 4-5 times a day with an interval between instillations of 2.5-3 hours. The daily dose is 12,000 μg (24 drops or 1.2 ml) - 20,000 μg 40 drops or 2.0 ml). The drug is prescribed daily for 10 days.
SIDE EFFECT

With prolonged use, slight irritation of the nasal mucosa is possible.

CONTRAINDICATIONS

- hypersensitivity to the components of the drug;

acute mental disorders;

- anxiety disorders;

- children's age till 18 years;

- pregnancy, lactation period;

- cramps in the anamnesis.

PREGNANCY AND LACTATION

Contraindicated.
Clinical studies have not been conducted.
APPLICATION FOR CHILDREN

Contraindicated for children under 18 years.

OVERDOSE

The phenomenon of drug overdose so far has not been detected even with a significant increase in the single dose.

DRUG INTERACTION

Pharmaceutical.
Based on the chemical structure of the drug, the presence of chemically incompatible combinations is not expected: the drug is rapidly destroyed and does not enter the gastrointestinal tract.
Pharmacokinetic.
Given the chemical structure of the drug (heptapeptide - a synthetic analogue of adrenocorticotropic hormone, completely devoid of hormonal activity), the speed of absorption and the rate of entry into the blood, as well as the intraasal route of administration, the effect of other drugs on the pharmacokinetic parameters of Semax is not expected. Taking into account the method of introducing Semax (intranasal), it is undesirable to administer agents having a local vasoconstrictive effect when administered intranasally.
TERMS OF RELEASE FROM PHARMACY

On prescription.

TERMS AND CONDITIONS OF STORAGE

In the dark place at a temperature of not more than +10 ° C, do not allow freezing.
Keep out of the reach of children. Shelf life - 2 years.
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