Universal reference book for medicines
Product name: RANTUDIL FORTE (RANTUDIL FORTE)

Active substance: acemetacin

Type: NSAIDs

Manufacturer: MEDA MANUFACTURING (Germany)
Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..

PHARMACHOLOGIC EFFECT
NSAIDs.
Blocking COX disrupts the synthesis of prostaglandins and ATP production. Has anti-inflammatory, antipyretic and analgesic effect, inhibits platelet aggregation.
The analgesic effect is due to both central and peripheral action.

Affects the center of thermoregulation, reduces fever.

Reduces aggregation, platelet adhesion and thrombus formation by suppressing the synthesis of thromboxane A 2 in platelets.

INDICATIONS
Chronic rheumatoid arthritis, chronic psoriatic arthritis, osteoarthritis, Bechterew's disease, gouty arthritis, myositis, tenosynovitis, tendosynovitis, bursitis, lumbago, ishalgia, postoperative inflammation, soft tissue damage, and thrombophlebitis of superficial veins.

DOSING MODE
Is taken internally.

Depending on the indications and severity of the disease, adults - 60 mg 1-3 times / day.

If gout is exacerbated, 180 mg / day in 3 divided doses until the clinical symptoms disappear.
If necessary, patients without erosive-ulcerative gastrointestinal lesions at the beginning of treatment temporarily increase the dose to 300 mg / day: once 120 mg, then 60 mg every 8 hours. This dosage regimen, if necessary, is kept for the 2nd day. With a decrease in symptoms, the dose is reduced.
The maximum dose: 600 mg / day.

At doses over 180 mg / day do not use more than 7 days.

SIDE EFFECT
From the digestive system: nausea, vomiting, weakness, abdominal pain, diarrhea, anorexia, latent bleeding GIT, ulceration of the stomach or duodenum;
rarely - stomatitis, aphthous stomatitis, toxic hepatitis.
From the side of the nervous system: headache, dizziness, drowsiness, increased fatigue;
less often - anxiety, confusion, psychosis, hallucinations, depression, irritability, peripheral neuropathy.
From the musculoskeletal system: rarely - muscle weakness, weakness in the muscles.

On the part of metabolism: rarely - edema, hyperkalemia, increased urea, hyperproteinemia, hyperglycemia, glucosuria.

From the cardiovascular system: rarely - increased blood pressure, stenocardia.

On the part of the hematopoiesis system: leukopenia, anemia, thrombocytopenia, agranulocytosis, pancytopenia.

From the senses: rarely - tinnitus, hearing or vision impairment, diplopia;
with prolonged use - a violation of the function of the retina with a change in color and opacity of the cornea.
Other: allergic reactions, photodermatitis, urination disorders, metrorrhagia, increased symptoms of inflammation.

CONTRAINDICATIONS
Erosive-ulcerative lesions of the gastrointestinal tract (in the phase of exacerbation), gastrointestinal bleeding, aspirin asthma, hemophilia, hemorrhagic diathesis, hypoprothrombinemia, portal hypertension, avitaminosis K, renal failure, I and III trimesters of pregnancy, lactation period, hypersensitivity to acetylcholine .

PREGNANCY AND LACTATION
Contraindicated in the I and III trimesters of pregnancy and lactation (breastfeeding).

SPECIAL INSTRUCTIONS
With caution should be used in patients with gout, with liver disease, in children under 12 years with hyperthermia against a background of viral diseases (risk of developing Reye's syndrome).

Patients should not drink alcohol during treatment.

Impact on the ability to drive vehicles and manage mechanisms

Acetecacin can adversely affect the ability to concentrate attention and the speed of psychomotor reactions.

DRUG INTERACTION
Inducers of microsomal oxidation (phenytoin, ethanol in small doses, barbiturates, zixorin, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites.

Acetetacin reduces the effectiveness of uricosuric drugs;
enhances the effect of anticoagulants, antiaggregants, fibrinolytics, side effects of mineralocorticoids, GCS, estrogens; reduces the effectiveness of antihypertensive and diuretics; potentiates hypoglycemic effect of sulfonylurea derivatives.
Antacids and colestyramine reduce the absorption of acetemethacin.

Acetetacin increases the concentration in the blood of lithium preparations, methotrexate.

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