Composition, form of production and packaging
Drops of the eye in the form of a transparent, colorless or slightly colored liquid.
1 ml
clonidine 2.5 mg
Proxodolol 10 mg
Excipients: benzethonium chloride, sodium chloride, citric acid, sodium citrate pentasecylhydrate, water d / u.
1.3 ml - a tube-droppers (5) polymeric - packs cardboard.
1.5 ml - a tube-dropper (5) polymeric - packs cardboard.
2 ml - a tube-dropper (5) polymeric - packs cardboard.
5 ml - a tube-dropper (5) polymeric - packs cardboard.
5 ml - a bottle-droppers polymer (1) - packs cardboard.
10 ml - a bottle-droppers polymer (1) - packs cardboard.
INSTRUCTION FOR THE SPECIALIST.
Description of the drug approved by the manufacturer for the printed edition of 2011.
PHARMACHOLOGIC EFFECT
Combined antiglaucoma preparation. Clopheline and proxodolol reduce intraocular pressure by reducing the production of aqueous humor and increasing its outflow.
The effect occurs 15-30 minutes after instillation, reaches a maximum after 2-6 hours and lasts for 24 hours.
Does not affect the accommodation, refraction and the size of the pupil.
INDICATIONS
Different forms of glaucoma:
- open-angle;
- closed-angle (in combination with miotics);
- secondary (in case of insufficient effect of monotherapy with proxodolol or clonidine).
DOSING MODE
The drug is instilled in the conjunctival sac of the eye 1 drop 2 times / day. Perhaps a combination with pilocarpine, which is instilled 1-3 times / day.
SIDE EFFECT
AT single cases: decreased blood pressure, slow heart rate, dry mouth, drowsiness, weakness, dizziness, but to a lesser extent than from the use of one clonidine.
CONTRAINDICATIONS
- bronchial asthma;
- chronic obstructive pulmonary disease;
- Chronic heart failure;
bradycardia;
- AV-blockade of II-III degree;
- arterial hypotension;
- Pregnancy;
- Children's age (there is no sufficient experience of using the drug in children);
- individual hypersensitivity to the components of the drug.
With caution should take the drug for type 1 diabetes, peptic ulcer of the stomach and duodenum.
PREGNANCY AND LACTATION
If it is necessary to prescribe the drug during pregnancy, you should compare the benefits for the mother and the risk for the fetus.
It is not known whether active substances are excreted in breast milk, therefore it is recommended to abolish breast-feeding during the lactation period, at the time of application of the drug.
SPECIAL INSTRUCTIONS
During the period of application of the drug, it is not recommended to wear soft contact lenses. When using hard lenses, remove them before instillation and re-put them 15-20 minutes after instillation of the drug.
The dropper should be closed after each use. Do not touch the tip of the tube to the eye.
Impact on the ability to drive vehicles and manage mechanisms
Patients who, after instillation, temporarily lose visual clarity, it is not recommended to drive a car or work with complicated equipment, machines or any other complex equipment that requires a clear vision immediately after instillation of the drug.
OVERDOSE
Data on cases of overdose of Proxopheline are not provided.
DRUG INTERACTION
Increases the effect of pilocarpine on intraocular pressure.
With the simultaneous administration of systemic alpha or beta-blockers, it is possible to intensify their hypotensive effect.
TERMS OF RELEASE FROM PHARMACY
The drug is released by prescription.
TERMS AND CONDITIONS OF STORAGE
List A. The drug should be stored in a place protected from light, inaccessible to children, at a temperature not exceeding 15 В° РЎ. Shelf life - 2 years.
