Composition, form of production and packaging
Capsules hard gelatinous, size 3, with a white body and a blue lid; the contents of the capsule - powder from white to creamy-white, it is possible to form a cylindrical shape, easily disintegrating when touched.
1 caps.
piroxicam 10 mg
Excipients: microcrystalline cellulose, wheat starch, glycine, silicon dioxide colloid, talc, magnesium stearate.
Composition of the shell: gelatin, titanium dioxide, indigocarmine Fd & C Blue2.
10 pieces. - blisters (2) - packs of cardboard.
Capsules hard gelatinous, size 3, with a cream-colored body and an orange lid; the contents of the capsule - powder from white to creamy-white, it is possible to form a cylindrical shape, easily disintegrating when touched.
1 caps.
piroxicam 20 mg
Excipients: microcrystalline cellulose, wheat starch, glycine, silicon dioxide colloid, talc, magnesium stearate.
Composition of the shell: gelatin, titanium dioxide, iron oxide yellow, sunset yellow.
10 pieces. - blisters (2) - packs of cardboard.
INSTRUCTION FOR THE SPECIALIST.
Description of the drug approved by the manufacturer for the printed edition of 2005.
PHARMACHOLOGIC EFFECT
Non-steroidal anti-inflammatory drug from the group of oxicams. Has anti-inflammatory, analgesic and antipyretic effect.
The mechanism of action is associated with inhibition of prostaglandin synthesis due to inhibition of cyclooxygenase activity.
Relieves pain syndrome. Relieves or reduces inflammation and pain in joints at rest and during movement, reduces morning stiffness and swelling of the joints, contributes to an increase in the volume of movements.
The analgesic effect occurs 30 minutes after ingestion. The anti-inflammatory effect is manifested by the end of the first week of treatment. After a single dose, the effect lasts for 24 hours.
PHARMACOKINETICS
Suction
After ingestion piroxicam is well absorbed from the digestive tract. C max in plasma is achieved within 3-5 hours.
Distribution
Binding to plasma proteins is 98%. V d = 0.12-0.14 l / kg.
Metabolism
Metabolized in the liver by hydrolysis and conjugation.
Excretion
It is excreted from the body mainly with urine (2/3 of the dose taken) and in small amounts with feces. T 1/2 is about 36-45 hours.
INDICATIONS
- joint damage: rheumatoid arthritis, chronic polyarthritis, Bechterew's disease, Reiter's syndrome, psoriatic polyarthritis, arthrosis (coxarthrosis, gonarthrosis, spondylarthrosis and polyarthrosis);
- Soft tissue diseases: periarthritis, bursitis, tendinitis;
-shane-brachial syndrome, lumbago, sciatica;
-boles after surgical, orthopedic, gynecological, dental interventions;
- Post-traumatic conditions (pain syndrome with stretching, dislocations, fractures);
-gout;
-dysmenorrhea, adnexitis, cystitis.
DOSING MODE
The drug is prescribed in a daily dose of 20 mg. Take 1 time / day or divide into 2 divided doses.
With a strong clinical symptomatology, the daily dose can be briefly increased to 40 mg.
Capsules are taken orally during meals.
SIDE EFFECT
On the part of the digestive system: often - heartburn, nausea, vomiting, diarrhea, erosive and ulcerative lesions of the gastrointestinal tract with possible bleeding and perforations (the frequency of these disorders increases with an increase in the daily dose of the drug).
From the side of the central nervous system: dizziness, headache, drowsiness, disorientation.
Allergic reactions: itching, hives.
Dermatological reactions: photosensitization.
From the hemopoietic system: rarely - anemia, granulocytopenia.
From the urinary system: rarely - renal dysfunction.
CONTRAINDICATIONS
- indication in the anamnesis for bronchial asthma, hives, acute rhinitis associated with taking acetylsalicylic acid and other NSAIDs;
- ulcer disease of the stomach and duodenum in the phase of exacerbation;
-Disorders of a picture of peripheral blood of an unknown genesis (including in the anamnesis);
-expressive disorders of the liver and kidneys;
-pregnancy;
-period of lactation;
-Children and adolescents under 15;
-Increased sensitivity to piroxicam.
PREGNANCY AND LACTATION
Piroxicam is contraindicated in pregnancy and lactation.
APPLICATION FOR FUNCTIONS OF THE LIVER
Contraindicated in severe impairment of kidney function.
APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS
Contraindicated in severe violations of liver function.
APPLICATION FOR CHILDREN
The drug is contraindicated in children and adolescents under 15 years.
SPECIAL INSTRUCTIONS
With special caution should prescribe the drug to patients with gastrointestinal diseases (ulcerative colitis, Crohn's disease) in history, arterial hypertension, chronic heart failure, infectious diseases, as well as elderly patients.
With caution and only under the supervision of a doctor, the drug is prescribed for patients with bronchial asthma, allergic rhinitis, polyposis of the nose, chronic obstructive airways diseases.
During the period of taking the drug, simultaneous intake of alcohol should be avoided.
Impact on the ability to drive vehicles and manage mechanisms
During the period of taking the drug, one should not perform work requiring increased attention and speed of psychomotor reactions.
OVERDOSE
Symptoms: nausea, vomiting (at high doses - bloody), melena, lesser-like phenomena, tinnitus, clonic and tonic convulsions, coma, hemorrhagic diathesis, agranulocytosis, aplastic anemia, petechial or bullous rash, hives, kore or typhoid-like rashes; in predisposed patients - toxic-allergic shock.
Treatment: follow the generally accepted principles of clinical toxicology.
DRUG INTERACTION
With simultaneous use of Piroxicam with oral anticoagulants, sulfonamides, nalidixic acid, oral hypoglycemic drugs, triiodothyronine, cyclophosphamide, an increase in their concentration in the blood plasma is possible.
With simultaneous use with other NSAIDs, GCS increases the risk of allergic reactions and side effects from the gastrointestinal tract.
With the simultaneous use of Piroxicam can weaken the action of diuretics and antihypertensive agents.
With the simultaneous use of lithium drugs with Pyroxicam, an increase in the lithium content in blood plasma is possible.
TERMS AND CONDITIONS OF STORAGE
The drug should be stored in a dark place at a temperature of 15 В° to 25 В° C. Shelf life - 3 years.
Conditions of leave from pharmacies
The drug is released by prescription.
