Universal reference book for medicines
Product name: POLYDEXA WITH PHENYLEPHRINE (POLYDEXA WITH PHENYLEPHRINE)

Active substance: comb.
drug
Type: The drug with antibacterial, anti-inflammatory and vasoconstrictive action for topical application in ENT practice

Manufacturer: Laboratoires BOUCHARA-RECORDATI (France) manufactured by SOPHARTEX (France)
Composition, form of production and packaging
Spray nasal
in the form of a transparent, colorless liquid.

100 ml

neomycin sulfate 1 g (650,000 IU)

polymyxin B sulfate 1 000 000 units

dexamethasone sodium metasulfobenzoate 25 mg

phenylephrine hydrochloride 250 mg

Auxiliary substances: methylparahydroxybenzoate - 100 mg, lithium chloride 340 mg, citric acid 280 mg, lithium hydroxide 100 mg, macrogol 400-5 g, polysorbate 80-200 mg, purified water up to 100 ml.

15 ml - polyethylene bottles with a sprayer (1) - packs cardboard.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2012.

PHARMACHOLOGIC EFFECT

Combined preparation for topical application in otorhinolaryngology.
The therapeutic effect of Polidex's preparation with phenylephrine is due to the anti-inflammatory effect of dexamethasone on the nasal mucosa, the vasoconstrictive effect of phenylephrine and the antibacterial action of antibiotics of neomycin and polymyxin B. When combined with these antibiotics, the spectrum of antibacterial action extends to the majority of Gram-positive and Gram-negative microorganisms causing infectious and inflammatory diseases of the nasal cavity and paranasal sinuses.
PHARMACOKINETICS

Studies of the pharmacokinetics of the Polidex preparation with phenylephrine have not been carried out due to low systemic absorption.

INDICATIONS

Inflammatory and infectious diseases of the nasal cavity, pharynx, paranasal sinuses:

acute and chronic rhinitis;

- Acute and chronic rhinopharyngitis;

- sinusites.

DOSING MODE

Adults are prescribed for 1 injection 3-5 times / day in each nostril for 5-10 days.

Children aged 2.5 to 15 years - 1 injection 3 times / day in each nostril for 5-10 days.

SIDE EFFECT

Allergic reactions: rarely skin manifestations.

CONTRAINDICATIONS

- Suspicion of a closed-angle glaucoma;

- simultaneous use of MAO inhibitors;

- kidney disease, accompanied by albuminuria;

- Pregnancy;

- lactation (breastfeeding);

- Children's age up to 2.5 years;

- Hypersensitivity to the components of the drug.

PREGNANCY AND LACTATION

The preparation Polidexa with phenylephrine is contraindicated for use in pregnancy and lactation (breast-feeding).

APPLICATION FOR FUNCTIONS OF THE LIVER

Contraindicated use of the drug in diseases of the kidneys, accompanied by albuminuria.

The drug is not prescribed for patients with renal insufficiency.

APPLICATION FOR CHILDREN

Contraindicated in childhood to 2.5 years.
Children aged 2.5 to 15 years are prescribed 1 injection 3 times / day in each nostril for 5-10 days.
SPECIAL INSTRUCTIONS

The drug is not prescribed for patients with renal insufficiency.

Do not use to wash the paranasal sinuses.

With caution apply the drug in patients with arterial hypertension, ischemic heart disease, hyperthyroidism.

It should be borne in mind that the drug contains components that can give a positive result in the conduct of doping control in athletes.

OVERDOSE

Due to the low degree of absorption in the systemic blood flow, an overdose is unlikely.

DRUG INTERACTION

Drug interaction is due to the content of phenylephrine.
With the simultaneous use of guanethidine and drugs of this group, the hypertensive effect of phenylephrine is enhanced and, due to a decrease in sympathetic tone with guanethidine, a long mydriasis is possible. If this combination can not be avoided, then a doctor's observation is necessary.
TERMS OF RELEASE FROM PHARMACY

The drug is released by prescription.

TERMS AND CONDITIONS OF STORAGE

List B. The drug should be stored out of reach of children at a temperature of no higher than 25 В° C.
Shelf life - 3 years.
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