Universal reference book for medicines
Product name: PENTABUFEN (PENTABUFEN)

Active substance: comb.
drug
Type: Analgesic-antipyretics of combined composition

Producer: MOSCOW PHARMACEUTICAL FACTORY (Russia)
A typical clinical and pharmacological article
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..

PHARMACHOLOGIC EFFECT
Combined drug, the properties of which are due to the components that make up its composition.

Metamizole sodium - NSAID, a derivative of pyrazolone, by the mechanism of action practically does not differ from other NSAIDs (nonselectively blocks COX and reduces the formation of prostaglandin from arachidonic acid).
A distinctive feature is the slight severity of the anti-inflammatory effect, a weak effect on water-salt metabolism (sodium and water retention) and gastrointestinal mucosa. Has analgesic, antipyretic and some spasmolytic (with respect to the smooth muscles of the urinary and biliary tract) action.

Ibuprofen - NSAIDs;
has analgesic, antipyretic and anti-inflammatory effects due to the indiscriminate blockade of COX-1 and COX-2 and has an inhibitory effect on the synthesis of prostaglandins. Analgesic effect is most pronounced for inflammatory pains.

Caffeine - methylxanthine, which has a psychostimulating and analeptic effect, increases mental and physical performance, stimulates mental activity, motor activity, shortens the response time, temporarily reduces fatigue and drowsiness.


Phenobarbital - has a hypnotic, spasmolytic and miorelaksiruyuschee effect.
In small doses has a sedative effect.

Codeine has a central antitussive effect (by suppressing the excitability of the cough center), as well as an analgesic effect caused by excitation of opiate receptors in various parts of the central nervous system and peripheral tissues, leading to stimulation of the antinociceptive system and changes in emotional perception of pain.

INDICATIONS
Pain syndrome (of mild and moderate intensity) of different genesis:

- Arthralgia;

- myalgia;

- radiculitis;

- neuralgia;

- headache;

- toothache;

- Migraine.


Catarrhal diseases - as a symptomatic therapy (including as an antipyretic drug):

- ARVI;

- The flu.

DOSING MODE
Inside, adults and children over 12 years - 1 tab.
1-3 times / day, washing with water. The maximum daily dose is 4 tablets.

Do not take more than 5 days as an anesthetic drug and more than 3 days - as an antipyretic without consulting a doctor.
If the symptoms persist for 2-3 days, the treatment should be discontinued and consult a doctor.
SIDE EFFECT
Occur with prolonged (more than 2-3 days) application.

On the part of the digestive system: nausea, vomiting, heartburn, anorexia, discomfort in epigastrium, diarrhea, flatulence, impaired liver function.


From the side of the central nervous system : headache, dizziness, hearing loss, tinnitus, insomnia, agitation, drowsiness, depression.


From the cardiovascular system: heart failure, tachycardia.


From the urinary system: edematic syndrome, impaired renal function.


On the part of the hematopoiesis system: anemia, thrombocytopenia, agranulocytosis, leukopenia.


Allergic reactions: skin rash, itching, hives, angioedema.


Other: bronchospasm, respiratory depression, sweating.

CONTRAINDICATIONS
hypersensitivity;

- Hepatic and / or renal insufficiency;

- Stomach ulcer and duodenal ulcer in the stage of exacerbation;

- chronic constipation;

- bronchial asthma;

- hives;

- rhinitis against the background of the use of acetylsalicylic acid and other NSAIDs;

- Diseases of the optic nerve;

- violation of color vision;

- amblyopia;

- scotoma;

- oppression hemopoiesis (agranulocytosis, cytostatic or infectious neutropenia);

- respiratory depression;

- intracranial hypertension;

- craniocerebral trauma;

- hearing loss;

- pathology of the vestibular apparatus;

- arterial hypertension;

- Pregnancy;

- lactation period;

- Children's age (up to 12 years).

With caution : gastric and duodenal ulcer in remission, gastritis, enteritis, colitis, concomitant liver and / or kidney disease, chronic heart failure, blood diseases of unclear etiology, bronchial asthma, urticaria, rhinitis, polyps of the nasal mucosa, hyperbilirubinemia, hypothyroidism, advanced age.

PREGNANCY AND LACTATION
The drug is contraindicated for use in pregnancy and lactation.

APPLICATION FOR FUNCTIONS OF THE LIVER
The drug is contraindicated for use in renal failure.

APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS
The drug is contraindicated for use in liver failure.

APPLICATION FOR CHILDREN
The drug is contraindicated for use in children under 12 years of age.

APPLICATION IN ELDERLY PATIENTS
Use with caution in elderly patients.

SPECIAL INSTRUCTIONS
With prolonged (more than 5 days) use of the drug, control of the picture of peripheral blood and the functional state of the liver is necessary.


The purpose of the drug in acute abdominal pain can make it difficult to establish a diagnosis.


Can change the results of tests of doping control athletes.


If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the test.


During treatment it is necessary to refrain from driving motor vehicles and practicing potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

OVERDOSE
Symptoms: abdominal pain, nausea, vomiting, retardation, drowsiness, drowsiness, depression, headache, tinnitus, narrowing of the pupil.

Treatment: gastric lavage, the appointment of activated carbon, alkaline drink, forced diuresis, symptomatic therapy, with respiratory depression - the appointment of a specific antagonist - naloxone.

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