Universal reference book for medicines
Product name: POWERWORK (POWERCORT)

Active substance: clobetasol

Type: GCS for external use

Manufacturer: GLENMARK PHARMACEUTICALS (India)
Composition, form of production and packaging
Cream for external use 0.05%
white, homogeneous.

1 g

clobetasol propionate 500 μg

Excipients: paraffin white soft, paraffin liquid, cetomacrogol, sodium phosphate monohydrate, sodium phosphate dihydrate, butylhydroxytoluene, methyl parahydroxybenzoate, propyl parahydroxybenzoate, propylene glycol, purified water.

15 g - aluminum tubes (1) - cardboard packs.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2011.

PHARMACHOLOGIC EFFECT

GCS for external use.
It prevents the accumulation of neutrophils, reduces inflammatory exudation and production of lymphokines, inhibits the migration of macrophages, reduces the intensity of infiltration and granulation processes, has local anti-inflammatory, antipruritic, anti-allergic and anti-exsudative effects.
PHARMACOKINETICS

C max of clobetasol propionate is achieved in plasma 13 hours after the first application and is 0.63 ng / ml.
The systemic metabolism of clobetasol propionate after percutaneous absorption has not been studied.
INDICATIONS

- psoriasis;

- Eczema (various forms);

- Red flat lichen;

- discoid lupus erythematosus;

- Skin diseases resistant to therapy with less active GCS for topical application.

DOSING MODE

The cream is applied a thin layer on the affected skin 1-2 times / day until the effect is obtained.
Treatment can not be performed for more than 4 weeks without evaluating the need for continuation. To treat exacerbations of skin diseases, you can repeat short short courses by Powercourt. If it is necessary to continue therapy with GCS, less active drugs should be used.
In particularly resistant cases, especially in the presence of hyperkeratosis, the anti-inflammatory effect of Powucourt cream can be enhanced by applying a bandage of polyethylene film overnight to the area of ​​application of the drug, which is usually accompanied by a positive effect.
In the future, the achieved effect can be maintained without the use of an occlusive dressing.
SIDE EFFECT

Long-term use of GCS for topical application in large doses or applying them to large areas of the skin can be accompanied by systemic absorption with the subsequent development of symptoms of hypercorticoidism.
The risk of developing this complication is increased in children, especially with the use of an occlusive dressing, while the diaper can serve as a bandage.
Given the appointment Pow Powrothra to adult patients in a dosage of not more than 50 g per week, suppression of the pituitary and adrenal glands function is transient in nature with their rapid recovery immediately after the end of the course of treatment.

Prolonged treatment with high-activity GCS for topical application in large doses can cause atrophic changes in the skin, in particular, its thinning, the appearance of atrophic striae, the widening of the superficial blood vessels, especially with the application of occlusive dressings and when applying the drug to skin areas with folds.
Skin pigmentation and hypertrichosis may develop. In rare cases, treatment of psoriasis SCS for topical application (or their cancellation) provokes the development of pustular psoriasis.
Sometimes Powucourt can cause an exacerbation of the symptoms of the disease.

CONTRAINDICATIONS

- rosacea;

- Acne vulgaris;

- skin cancer;

- nodal pruritis of Gaida;

- perioral dermatitis;

- perianal and genital itching;

- bacterial, viral and fungal skin diseases (herpes simplex, chicken pox, skin tuberculosis, actinomycosis);

- common plaque and pustular psoriasis;

- age up to 1 year;

- lactation period;

- Hypersensitivity to the components of the drug.

PREGNANCY AND LACTATION

SCS for topical application should not be used during pregnancy for a long time in large doses.

The safety of the use of clobetasol propionate during lactation is not established.

APPLICATION FOR CHILDREN

The use of GCS for topical administration for a long time should be avoided, especially in the treatment of young children, since suppression of adrenal function may occur.
The use of Powourcott in children requires the supervision of a doctor at least once a week. Contraindication: children under 1 year.
SPECIAL INSTRUCTIONS

The use of GCS for topical administration for a long time should be avoided, especially in the treatment of young children, since suppression of adrenal function may occur.
The use of Powourcott in children requires the supervision of a doctor at least once a week.
On the face more often than in other parts of the body, atrophic changes in the skin can occur as a result of prolonged use of local SCS.

When applying the cream on the eyelids, care should be taken to ensure that the product does not get into the eyes, because this can cause glaucoma.

Treatment of psoriasis for local application may be accompanied by the development of relapses of the disease, tolerance to the drug, generalized pustular form of the disease, local or systemic toxic reactions due to violation of the barrier function of the skin, so careful monitoring of the patient is especially important.

When attaching a secondary infection, appropriate antibiotic therapy should be carried out.
With any signs of generalization of the infection, it is necessary to stop the local use of SCS and conduct appropriate treatment with antibacterial drugs.
Warm moist conditions created with the application of an occlusive dressing, contribute to the emergence of a bacterial infection, so you should always clean the skin before applying a new bandage.

The cream is not recommended to plant.

Impact on the ability to drive vehicles and manage mechanisms

It is unlikely that clobetasol propionate affects the ability to drive vehicles and control mechanisms.

OVERDOSE

The development of acute overdose is unlikely.
However, in case of chronic overdose or misuse, symptoms of hypercorticism may develop, which requires a gradual discontinuation of the drug under the supervision of a physician.
DRUG INTERACTION

No data.

TERMS OF RELEASE FROM PHARMACY

The drug is released by prescription.

TERMS AND CONDITIONS OF STORAGE

List B. The drug should be stored out of reach of children, dry, protected from light at a temperature of no higher than 25 ° C.
Shelf life - 2 years.
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