Universal reference book for medicines
Name of the preparation: OCUMOL

Active ingredient: timolol

Type: anti-glaucoma preparation - beta-blocker

Manufacturer: WAVE PHARMACEUTICALS (India)
Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..

PHARMACHOLOGIC EFFECT
Non-selective beta-blocker.
With topical application in ophthalmology reduces both normal and increased intraocular pressure by reducing the formation of intraocular fluid and improving its outflow, it does not affect the accommodation and the size of the pupil.
Has antianginal, hypotensive and antiarrhythmic effects, which are manifested in systemic application.
Reduces the automatism of the sinus node, reduces heart rate, slows AV-conduction, reduces contractility and the need for myocardium in oxygen.
PHARMACOKINETICS
With topical application quickly penetrates through the cornea, in an insignificant amount gets into the systemic bloodstream due to the absorption through the vessels of the conjunctiva, the mucous membranes of the nose and the lacrimal tract.

INDICATIONS
For use in ophthalmology: increased intraocular pressure, chronic open-angle glaucoma, closed-angle glaucoma (as an additional tool in combination with miotics), secondary glaucoma (including aphakic), congenital glaucoma (with ineffectiveness of other therapeutic measures).

DOSING MODE
In ophthalmology: instillation in the conjunctival sac of the affected eye.
The dose and the frequency of application depend on the indications and the dosage form used.
SIDE EFFECT
From the side of the organ of vision: with local application, irritation and hyperemia of the conjunctiva, skin of the eyelids, burning and itching in the eyes, lacrimation, photophobia, corneal epithelial edema, spot surface keratopathy, corneal hypopsy, diplopia, ptosis, dry eyes.
When performing fistulizing antiglaucoma operations, retinal detachment may develop in the postoperative period.
With systemic application , heart failure, bradycardia, AV blockade, arterial hypotension;
headache, sleep disturbances, nightmares, asthenia, agitation, depression, paresthesia and cold extremities; nausea, vomiting, diarrhea; shortness of breath, bronchospasm; muscle weakness; skin allergic reactions, exacerbation of psoriasis, dryness of the conjunctiva.
CONTRAINDICATIONS
AV blockade of II and III degree, sinoatrial block, bradycardia, SSSU, arterial hypotension, chronic heart failure of IIB-III stage, acute heart failure, vasomotor rhinitis, Raynaud's disease and other obliterating vascular diseases, metabolic acidosis, lactation.

PREGNANCY AND LACTATION
Safety and effectiveness of use in pregnancy have not been studied.

APPLICATION FOR FUNCTIONS OF THE LIVER
Use with caution in patients with impaired renal function.

APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS
Use with caution in patients with impaired hepatic function.

APPLICATION FOR CHILDREN
Safety and efficacy in children have not been studied



SPECIAL INSTRUCTIONS
Use with caution in patients with impaired liver function, kidney function, diabetes mellitus (especially labile course).
With prolonged use increases the level of triglycerides in the blood plasma.
Safety and efficacy in children have not been studied.

In ophthalmology it is used for a long time, therefore, during the treatment period, at least once every 6 months, the cornea should be inspected, the lacrimal function and the condition of the visual fields should be monitored.

Impact on the ability to drive vehicles and manage mechanisms

During the treatment period, one should refrain from engaging in potentially dangerous activities requiring increased attention, rapid psychomotor reactions.

When used in ophthalmology immediately after instillation, it is possible to reduce visual acuity and slowing down of psychomotor reactions, so it is necessary to refrain from practicing for potentially dangerous activities that require more attention within 30 minutes.

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