Composition, form of production and packaging
Powder for the preparation of a solution for the / m introduction (or porous mass) of a white with a yellowish tint of color, forming a clear, almost colorless solution when dissolved.
1 f.
ampicillin sodium 333.33 mg
Oxacillin sodium 166.67 mg
Vials with a volume of 10 ml (10) - cardboard boxes.
Vials with a volume of 10 ml (50) - carton boxes.
Powder for the preparation of a solution for intravenous administration (or porous mass) of white with a yellowish hue of color, forming a clear, almost colorless solution when dissolved.
1 f.
ampicillin sodium 333.33 mg
Oxacillin sodium 166.67 mg
Vials with a volume of 10 ml (10) - carton boxes.
Vials with a volume of 10 ml (50) - carton boxes.
INSTRUCTION FOR THE SPECIALIST.
The product description was approved by the manufacturer for the 2004 print edition.
PHARMACHOLOGIC EFFECT
Combined antibacterial drug.
Oxacillin is an antibiotic from the group of semisynthetic penicillins. It acts bactericidal, suppressing the synthesis of the bacterial cell wall. Resistant to the action of penicillinase. It is active against gram-positive bacteria: Staphylococcus spp. (including those producing penicillinase), Streptococcus spp. (including Streptococcus pneumoniae), Corynebacterium diphtheriae, Bacillus anthracis; Gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis; anaerobic bacteria: spore-forming bacillus, Actinomyces spp. Most gram-negative bacteria, rickettsia, viruses, protozoa, fungi are resistant to oxacillin.
Ampicillin is an antibiotic from the group of semisynthetic penicillins. It acts bactericidal, suppressing the synthesis of the bacterial cell wall. It is active against gram-positive bacteria: Staphylococcus spp. (with the exception of strains producing penicillinase), Streptococcus spp. (including Enterococcus spp.), non-spore-forming bacteria (including Listeria monocytogenes); Gram-negative aerobic bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Bordetella pertussis, some strains of Haemophilus influenzae.
Ampicillin is destroyed by the action of penicillinase.
The combination of ampicillin with oxacillin is rational, because The latter, suppressing the activity of penicillinase, reduces thereby the destruction of ampicillin. The spectrum of action with this combination becomes wider.
PHARMACOKINETICS
Suction
C max of active substances is achieved after 0.5-1 h after IM. With IV administration, high concentrations are rapidly created in the blood, exceeding those in the IM injection.
Distribution and deduction
With repeated administration of active substances do not accumulate in the body, which makes it possible to apply the drug for a long time. They are excreted in the urine.
INDICATIONS
- respiratory tract infections (including bronchitis, pneumonia, bronchiectasis);
- diseases of the biliary tract (including cholangitis, cholecystitis);
- Urinary tract and kidney infections (including pyelitis, pyelonephritis, cystitis);
- infections of the skin and soft tissues (including infected wounds);
- burn disease;
- angina.
Prevention of postoperative complications in surgical interventions.
Prevention and treatment of infections in newborns.
DOSING MODE
The drug is given in / m or in / in (jet or drip).
A single dose for adults is 0.5-1 g, the daily dose is 2-4 g.
Newborns, premature infants and children under the age of 1 year, the drug is prescribed in a daily dose of 100-200 mg / kg body weight; 1-7 years - 100 mg / kg / day; 7-14 years - 50 mg / kg / day; Adolescents over 14 years of age are prescribed a dose for adults.
In severe infection, these doses can be increased by a factor of 1.5-2. The daily dose is administered in 3-4 divided doses at intervals of 6-8 hours. Duration of treatment is from 5-7 days to 3 weeks or more.
In / in the drug administered for 5-7 days with a subsequent transition (if necessary) to the / m introduction.
Rules for the preparation and administration of solutions
Solutions for the / m introduction are prepared immediately before administration, adding to the contents of the bottle 2 ml of sterile water for injection.
For IV infusion, the drug (single dose) is dissolved in 10-15 ml of water for injection or isotonic sodium chloride solution and injected slowly for 2-3 minutes.
For intravenous drip for adults, the drug (single dose) is dissolved in 100-200 ml of isotonic sodium chloride solution or 5-10% dextrose solution and injected at a rate of 60-80 drops / min. When drip introduction to children as a solvent used 5-10% solution of dextrose (30-100 ml, depending on age).
SIDE EFFECT
Allergic reactions: skin rash, hives, swelling of Quincke; rarely anaphylactic shock.
Local reactions: with iv introduction, development of phlebitis and periphlebitis is possible; with the / m introduction - soreness at the injection site.
CONTRAINDICATIONS
- Hypersensitivity to the components of the drug and other antibiotics from the penicillin group.
PREGNANCY AND LACTATION
It is possible to use the drug Oxamp-sodium during pregnancy according to the indications. It is excreted in breast milk in low concentrations.
SPECIAL INSTRUCTIONS
When allergic reactions occur, it is necessary to stop the drug administration and conduct desensitizing therapy.
With the development of anaphylactic shock, the introduction of epinephrine, GCS (hydrocortisone or prednisolone), bronchodilators, blockers of histamine H 1 -receptors; if necessary, carry out mechanical ventilation.
Use in Pediatrics
Caution should be given to prescribing to children if a history of the mother indicates an increased sensitivity to penicillins. In such cases, when it is necessary to prescribe the drug Oxamp-sodium in the presence of concomitant diseases (bronchial asthma, hay fever and other allergic diseases), the simultaneous use of desensitizing drugs is shown.
OVERDOSE
At present, cases of overdose of Oksamp-sodium preparation have not been reported.
DRUG INTERACTION
Synergism of antibacterial action is observed when the drug is combined with bactericidal antibiotics - aminoglycosides, cephalosporins, vancomycin, rifampicin.
TERMS OF RELEASE FROM PHARMACY
The drug is released by prescription.
TERMS AND CONDITIONS OF STORAGE
List B. The drug should be stored in a dry, dark place at room temperature. Shelf life - 2 years.
